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• W2031522013 abstract "Objective To examine the association between the apolipoprotein E (APOE) gene and early age-related maculopathy (ARM) in middle-aged persons. Design Population-based cross-sectional study. Participants Participants from the Atherosclerosis Risk in Communities Study (n = 10 139; age range, 49–73 years). Methods Retinal photography was performed on 1 randomly selected eye, and grading for presence of ARM was carried out using a modification of the Wisconsin ARM Grading System. Early ARM was defined as the presence of either soft drusen alone, retinal pigment epithelial depigmentation alone, or a combination of soft drusen with increased retinal pigment and/or depigmentation. DNA extracted from blood samples of participants were analyzed for common allelic variants of the APOE gene (ϵ2, ϵ3, and ϵ4). Main Outcome Measures Presence of early ARM on retinal photographs. Results The prevalence of early ARM was similar in participants with different APOE genotypes: ϵ2/ϵ2 (5.9%), ϵ2/ϵ3 (5.2%), ϵ2/ϵ4 (3.2%), ϵ3/ϵ3 (5.2%), ϵ3/ϵ4 (4.9%), and ϵ4/ϵ4 (4.1%). After controlling for age, gender, race, cigarette smoking, and other factors, early ARM was not associated with APOE genotypes, with an odds ratio (OR) of 1.35 (95% confidence interval [CI], 0.54–3.38) for ϵ2/ϵ2 genotype, an OR of 1.06 (95% CI, 0.80–1.40) for ϵ2/ϵ3 genotype, an OR of 0.63 (95% CI, 0.32–1.24) for ϵ2/ϵ4 genotype, an OR of 0.99 (95% CI, 0.80–1.24) for ϵ3/ϵ4 genotype, and an OR of 0.88 (95% CI, 0.47–1.63) for ϵ4/ϵ4 genotype, as compared with ϵ3/ϵ3 genotype (reference). No associations were found for specific early ARM signs or in analyses stratified by age, gender, race, or cigarette smoking status. Conclusions These data provide no evidence of a strong association between the APOE gene and early ARM in middle-aged persons. This suggests that APOE is not likely a major determinant of the early stages of ARM in younger people. However, our study does not exclude the possibility of a weaker association or that APOE may influence only the development of late ARM in older populations, as reported in other studies. To examine the association between the apolipoprotein E (APOE) gene and early age-related maculopathy (ARM) in middle-aged persons. Population-based cross-sectional study. Participants from the Atherosclerosis Risk in Communities Study (n = 10 139; age range, 49–73 years). Retinal photography was performed on 1 randomly selected eye, and grading for presence of ARM was carried out using a modification of the Wisconsin ARM Grading System. Early ARM was defined as the presence of either soft drusen alone, retinal pigment epithelial depigmentation alone, or a combination of soft drusen with increased retinal pigment and/or depigmentation. DNA extracted from blood samples of participants were analyzed for common allelic variants of the APOE gene (ϵ2, ϵ3, and ϵ4). Presence of early ARM on retinal photographs. The prevalence of early ARM was similar in participants with different APOE genotypes: ϵ2/ϵ2 (5.9%), ϵ2/ϵ3 (5.2%), ϵ2/ϵ4 (3.2%), ϵ3/ϵ3 (5.2%), ϵ3/ϵ4 (4.9%), and ϵ4/ϵ4 (4.1%). After controlling for age, gender, race, cigarette smoking, and other factors, early ARM was not associated with APOE genotypes, with an odds ratio (OR) of 1.35 (95% confidence interval [CI], 0.54–3.38) for ϵ2/ϵ2 genotype, an OR of 1.06 (95% CI, 0.80–1.40) for ϵ2/ϵ3 genotype, an OR of 0.63 (95% CI, 0.32–1.24) for ϵ2/ϵ4 genotype, an OR of 0.99 (95% CI, 0.80–1.24) for ϵ3/ϵ4 genotype, and an OR of 0.88 (95% CI, 0.47–1.63) for ϵ4/ϵ4 genotype, as compared with ϵ3/ϵ3 genotype (reference). No associations were found for specific early ARM signs or in analyses stratified by age, gender, race, or cigarette smoking status. These data provide no evidence of a strong association between the APOE gene and early ARM in middle-aged persons. This suggests that APOE is not likely a major determinant of the early stages of ARM in younger people. However, our study does not exclude the possibility of a weaker association or that APOE may influence only the development of late ARM in older populations, as reported in other studies." @default.
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• W2031522013 date "2006-02-01" @default.
• W2031522013 modified "2023-10-12" @default.
• W2031522013 title "Apolipoprotein E Gene and Early Age-Related MaculopathyThe Atherosclerosis Risk in Communities Study" @default.
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• W2031522013 doi "https://doi.org/10.1016/j.ophtha.2005.10.048" @default.
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