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• W2031534128 abstract "The generation of transgenic non-human primates provides a potential means to understand the genetic differences that distinguish humans from our nearest evolutionary relatives. However, the same features that make non-human primates good models for such research also raise serious ethical concerns. A flood of comparative genomic data is resulting in the identification of human lineage-specific (HLS) sequences. As apes are our closest evolutionary relatives, transgenic introduction of HLS sequences into these species has the greatest potential to produce 'humanized' phenotypes and also to illuminate the functions of these sequences. We argue that such transgenic apes would also be more likely than other species to experience harm from such research, which renders such studies ethically unacceptable in apes and justifies regulatory barriers between these species and other non-human primates for HLS transgenic research." @default.
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• W2031534128 date "2010-09-01" @default.
• W2031534128 modified "2023-10-16" @default.
• W2031534128 title "The ethics of using transgenic non-human primates to study what makes us human" @default.
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• W2031534128 doi "https://doi.org/10.1038/nrg2864" @default.
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