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• W2031551838 abstract "The role of the endolymphatic sac (ES) in endolymph volume homeostasis is speculative. The present study investigates changes of the ES’s epithelia and luminal filling after induction of an acute endolymphatic hydrops. After microinjection of 1.1 μl artificial endolymph into scala media of the cochlea, guinea pigs were terminated immediately (n = 6) or after different time intervals ; 1/2 h (n = 3), 1 h (n = 4) and 2 h (n = 4). Inner ear specimens were processed for light and/or transmission electron microscopy. The non-injected contralateral ear served as a histological control. Correct injection was confirmed by detection of microspheres in the endolymphatic compartment after the same microinjection procedure. In all specimens, ribosome rich cells and intraluminal macrophages appeared to be actively involved in degradation of homogeneous substance (HS) by secreting lytic enzymes and digestion, respectively. Amazingly, in our study no ES differences were found between injected and non-injected ears and no distinct changes were observed in guinea pigs terminated after different time intervals. The ES’s luminal HS was always present and often to a large extent. This is in contrast with [Hear. Res. 138, 81] dramatic changes were observed. Endolymph volume homeostasis is a complex mechanism, in which the role of HS remains obscure." @default.
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• W2031551838 date "2005-04-01" @default.
• W2031551838 modified "2023-10-16" @default.
• W2031551838 title "Morphology of the endolymphatic sac in the guinea pig after an acute endolymphatic hydrops" @default.
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• W2031551838 doi "https://doi.org/10.1016/j.heares.2004.10.010" @default.
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