FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031553508> ?p ?o ?g. }

• W2031553508 endingPage "259" @default.
• W2031553508 startingPage "259" @default.
• W2031553508 abstract "Metals enriched in ambient air fine particulate matter (PM2.5) are thought to contribute to the pathogenesis of PM2.5-induced inflammatory lung diseases. An important mechanism involved in metal-induced lung injury involves increased oxidative stress due to generation of reactive oxygen species. The redox sensitive transcription factor, nuclear factor kappa B (NF-κB) converts extracellular oxidative stress signals into changes in expression of genes associated with diverse cellular activities. The purpose of this study was to determine the mechanism by which exposure to Fe or Se, at environmentally relevant concentrations, leads to an increased release of chemokines by cultured human lung epithelial cells (A549). We tested the hypothesis that NF-κB signaling pathway is involved in the metal induced IL-8 and MCP-1 release by Fe and Se. Exposure to Fe or Se induced an enhanced release of chemokines at 6 and 24 h, and mediated nuclear translocation of NF-κB. Levels of chemokines in response to Fe were significantly suppressed in the presence of BMS-345541, a specific inhibitor of NF-κB. Similar effects were seen in response to Se, indicating the involvement of NF-κB in the metal-induced chemokine release, while not affecting the AP-1 c-Jun-DNA binding activity. Overall, results indicate that both Fe and Se, at ambient levels, possess the potential for inducing lung inflammation via an oxidative stress pathway in lung epithelial cells." @default.
• W2031553508 created "2016-06-24" @default.
• W2031553508 creator A5010143266 @default.
• W2031553508 creator A5015895055 @default.
• W2031553508 creator A5018205384 @default.
• W2031553508 creator A5072396716 @default.
• W2031553508 creator A5073986597 @default.
• W2031553508 date "2013-01-01" @default.
• W2031553508 modified "2023-09-27" @default.
• W2031553508 title "Role of NF-κB in the oxidative stress-induced lung inflammatory response to iron and selenium at ambient levels" @default.
• W2031553508 cites W1577403013 @default.
• W2031553508 cites W1590514634 @default.
• W2031553508 cites W1667711738 @default.
• W2031553508 cites W1786911182 @default.
• W2031553508 cites W1870638847 @default.
• W2031553508 cites W1966308856 @default.
• W2031553508 cites W1966779982 @default.
• W2031553508 cites W1968607063 @default.
• W2031553508 cites W1969229257 @default.
• W2031553508 cites W1978653090 @default.
• W2031553508 cites W1994272676 @default.
• W2031553508 cites W1998802482 @default.
• W2031553508 cites W2020518988 @default.
• W2031553508 cites W2026686875 @default.
• W2031553508 cites W2033098740 @default.
• W2031553508 cites W2034123820 @default.
• W2031553508 cites W2053302868 @default.
• W2031553508 cites W2053819319 @default.
• W2031553508 cites W2057141593 @default.
• W2031553508 cites W2060846985 @default.
• W2031553508 cites W2062711706 @default.
• W2031553508 cites W2066340162 @default.
• W2031553508 cites W2070584052 @default.
• W2031553508 cites W2071963896 @default.
• W2031553508 cites W2075240610 @default.
• W2031553508 cites W2075300121 @default.
• W2031553508 cites W2081745487 @default.
• W2031553508 cites W2081878008 @default.
• W2031553508 cites W2085885129 @default.
• W2031553508 cites W2090774505 @default.
• W2031553508 cites W2094863064 @default.
• W2031553508 cites W2099576328 @default.
• W2031553508 cites W2106877484 @default.
• W2031553508 cites W2109593620 @default.
• W2031553508 cites W2111345005 @default.
• W2031553508 cites W2118690237 @default.
• W2031553508 cites W2122734862 @default.
• W2031553508 cites W2129057340 @default.
• W2031553508 cites W2131118500 @default.
• W2031553508 cites W2137734141 @default.
• W2031553508 cites W2138078863 @default.
• W2031553508 cites W2140609241 @default.
• W2031553508 cites W2140665078 @default.
• W2031553508 cites W2141802124 @default.
• W2031553508 cites W2147291388 @default.
• W2031553508 cites W2161528133 @default.
• W2031553508 cites W2169781816 @default.
• W2031553508 cites W2335925695 @default.
• W2031553508 doi "https://doi.org/10.1039/c3tx50012h" @default.
• W2031553508 hasPublicationYear "2013" @default.
• W2031553508 type Work @default.
• W2031553508 sameAs 2031553508 @default.
• W2031553508 citedByCount "7" @default.
• W2031553508 countsByYear W20315535082013 @default.
• W2031553508 countsByYear W20315535082015 @default.
• W2031553508 countsByYear W20315535082017 @default.
• W2031553508 countsByYear W20315535082019 @default.
• W2031553508 countsByYear W20315535082020 @default.
• W2031553508 crossrefType "journal-article" @default.
• W2031553508 hasAuthorship W2031553508A5010143266 @default.
• W2031553508 hasAuthorship W2031553508A5015895055 @default.
• W2031553508 hasAuthorship W2031553508A5018205384 @default.
• W2031553508 hasAuthorship W2031553508A5072396716 @default.
• W2031553508 hasAuthorship W2031553508A5073986597 @default.
• W2031553508 hasConcept C104317684 @default.
• W2031553508 hasConcept C123298856 @default.
• W2031553508 hasConcept C126322002 @default.
• W2031553508 hasConcept C178790620 @default.
• W2031553508 hasConcept C185592680 @default.
• W2031553508 hasConcept C2776151105 @default.
• W2031553508 hasConcept C2776914184 @default.
• W2031553508 hasConcept C2777730290 @default.
• W2031553508 hasConcept C3020196126 @default.
• W2031553508 hasConcept C553756173 @default.
• W2031553508 hasConcept C55493867 @default.
• W2031553508 hasConcept C71924100 @default.
• W2031553508 hasConcept C78604142 @default.
• W2031553508 hasConcept C86339819 @default.
• W2031553508 hasConceptScore W2031553508C104317684 @default.
• W2031553508 hasConceptScore W2031553508C123298856 @default.
• W2031553508 hasConceptScore W2031553508C126322002 @default.
• W2031553508 hasConceptScore W2031553508C178790620 @default.
• W2031553508 hasConceptScore W2031553508C185592680 @default.
• W2031553508 hasConceptScore W2031553508C2776151105 @default.
• W2031553508 hasConceptScore W2031553508C2776914184 @default.
• W2031553508 hasConceptScore W2031553508C2777730290 @default.
• W2031553508 hasConceptScore W2031553508C3020196126 @default.
• W2031553508 hasConceptScore W2031553508C553756173 @default.

• next