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• W2031566338 abstract "Background and Aim: A single nucleotide polymorphism in heat shock protein 70-2 (HSP70-2) has been shown to be associated with a severe clinical course in Crohn's disease (CD), but it is not known if such a relationship exists in ulcerative colitis (UC). The aim of the present study was to identify associations between the HSP70-2 polymorphism and the clinical courses of CD and UC in Koreans. Methods: Restriction fragment length polymorphism analysis was performed for HSP70-2 polymorphisms using the PstI-cleavage site present in the B allele but not in the A allele of the DNA obtained from 101 patients with CD, 144 patients with UC, and 245 age- and sex-matched healthy controls. Study subjects were classified by disease behavior, severity and extent of disease. Results: In CD, multivariate analysis showed that the AA genotype of HSP70-2 polymorphisms was associated with non-perforating disease (OR 10.10, 95% CI 1.66–15.38) and male sex (OR 3.56, 95% CI 1.04–12.23), and that the BB genotype was associated with severe CD (OR 12.03, 95% CI 1.60–101.56). In contrast, multivariate analysis for UC showed that the AA genotype was associated with severe UC (OR 2.02, 95% CI 1.34–3.03). Conclusions: CD patients with BB genotype of HSP70-2 polymorphism tend to experience a more severe clinical course and allele A is associated with more severe UC. HSP70-2 polymorphism may be used to predict CD and UC phenotypes, which can illuminate immunological differences in CD and UC." @default.
• W2031566338 created "2016-06-24" @default.
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• W2031566338 date "2007-07-01" @default.
• W2031566338 modified "2023-09-27" @default.
• W2031566338 title "Heat shock protein gene 70-2 polymorphism is differentially associated with the clinical phenotypes of ulcerative colitis and Crohn's disease" @default.
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• W2031566338 doi "https://doi.org/10.1111/j.1440-1746.2007.04927.x" @default.
• W2031566338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17532782" @default.
• W2031566338 hasPublicationYear "2007" @default.
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