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• W2031567366 abstract "Total RNA was extracted from skin biopsies of nine patients suffering from systemic sclerosis (SSc). Steady-state mRNA levels of collagen alpha 1(I) and alpha 1(III), collagenase, fibronectin, and beta-actin were studied using specific cDNA probes and compared to those of 12 sex- and age-matched healthy individuals. There was a more than three-fold elevation of collagen I mRNA levels in SSc skin compared to controls. No difference was found, however, for collagen III, collagenase, and fibronectin mRNA levels in SSc and control biopsies. The selective increase of collagen alpha 1(I) mRNA levels indicates a specific alteration of fibroblast metabolism in scleroderma. Analysis of mRNA levels in skin biopsies might not only offer a direct approach to the understanding of the pathophysiology of SSc, but also facilitate the monitoring of fibrotic activity in SSc patients during therapeutic trials." @default.
• W2031567366 created "2016-06-24" @default.
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• W2031567366 date "1991-08-01" @default.
• W2031567366 modified "2023-10-16" @default.
• W2031567366 title "Steady-State mRNA Levels of Collagens I, III, Fibronectin, and Collagenase in Skin Biopsies of Systemic Sclerosis Patients" @default.
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• W2031567366 doi "https://doi.org/10.1111/1523-1747.ep12480157" @default.
• W2031567366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1649227" @default.
• W2031567366 hasPublicationYear "1991" @default.
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