Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031567502> ?p ?o ?g. }
- W2031567502 endingPage "1485" @default.
- W2031567502 startingPage "1478" @default.
- W2031567502 abstract "Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity. An adipocyte-derived hormone, adiponectin, may play a role in the pathophysiology of NAFLD through insulin-sensitizing and antifibrotic effects. We found that hepatic expression of adiponectin receptor AdipoR2, but not AdipoR1, was down-regulated in 14 patients with NAFLD compared with 7 patients with a normal liver (P < .05). To investigate the significance of the adiponectin system in obesity and NAFLD, we examined the regulation of AdipoR2 expression in a nonmalignant human hepatocyte cell line, the THLE-5b cells. Insulin down-regulated the levels of AdipoR2 messenger RNA (mRNA) and protein, whereas an adipocytokine, tumor necrosis factor alpha, up-regulated them. A thiazolidinedione, pioglitazone, up-regulated the expression of AdipoR2 mRNA and protein in THLE-5b cells. The AdipoR2 mRNA level was decreased in fatty THLE-5b cells induced by coincubating with fatty acids. These findings suggest that down-regulation of AdipoR2 in the liver caused by hyperinsulinemia and steatosis may play a role in the development of NAFLD." @default.
- W2031567502 created "2016-06-24" @default.
- W2031567502 creator A5008003570 @default.
- W2031567502 creator A5010525884 @default.
- W2031567502 creator A5039655833 @default.
- W2031567502 creator A5040046754 @default.
- W2031567502 creator A5046506553 @default.
- W2031567502 creator A5046757453 @default.
- W2031567502 creator A5059195352 @default.
- W2031567502 creator A5064494964 @default.
- W2031567502 creator A5069065380 @default.
- W2031567502 creator A5076022267 @default.
- W2031567502 creator A5080215605 @default.
- W2031567502 creator A5081432607 @default.
- W2031567502 creator A5085142320 @default.
- W2031567502 creator A5089497139 @default.
- W2031567502 date "2007-11-01" @default.
- W2031567502 modified "2023-10-17" @default.
- W2031567502 title "Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line" @default.
- W2031567502 cites W1587875569 @default.
- W2031567502 cites W1970374778 @default.
- W2031567502 cites W1971452427 @default.
- W2031567502 cites W1975898092 @default.
- W2031567502 cites W1977188464 @default.
- W2031567502 cites W1977405708 @default.
- W2031567502 cites W1981261500 @default.
- W2031567502 cites W1997978122 @default.
- W2031567502 cites W2009172922 @default.
- W2031567502 cites W2019280401 @default.
- W2031567502 cites W2026547431 @default.
- W2031567502 cites W2027391841 @default.
- W2031567502 cites W2033654570 @default.
- W2031567502 cites W2059263244 @default.
- W2031567502 cites W2067416779 @default.
- W2031567502 cites W2082199390 @default.
- W2031567502 cites W2087829753 @default.
- W2031567502 cites W2097794068 @default.
- W2031567502 cites W2102677290 @default.
- W2031567502 cites W2103156933 @default.
- W2031567502 cites W2111703671 @default.
- W2031567502 cites W2112377527 @default.
- W2031567502 cites W2113454882 @default.
- W2031567502 cites W2118723490 @default.
- W2031567502 cites W2124038922 @default.
- W2031567502 cites W2124664603 @default.
- W2031567502 cites W2125946144 @default.
- W2031567502 cites W2127934772 @default.
- W2031567502 cites W2129316761 @default.
- W2031567502 cites W2131702141 @default.
- W2031567502 cites W2142844314 @default.
- W2031567502 cites W2145725957 @default.
- W2031567502 cites W2160234571 @default.
- W2031567502 cites W2163717842 @default.
- W2031567502 cites W2164118055 @default.
- W2031567502 cites W2171407792 @default.
- W2031567502 cites W4230284962 @default.
- W2031567502 cites W4235391466 @default.
- W2031567502 cites W4237813261 @default.
- W2031567502 cites W4239191207 @default.
- W2031567502 cites W4243857162 @default.
- W2031567502 doi "https://doi.org/10.1016/j.metabol.2007.06.013" @default.
- W2031567502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17950097" @default.
- W2031567502 hasPublicationYear "2007" @default.
- W2031567502 type Work @default.
- W2031567502 sameAs 2031567502 @default.
- W2031567502 citedByCount "39" @default.
- W2031567502 countsByYear W20315675022012 @default.
- W2031567502 countsByYear W20315675022013 @default.
- W2031567502 countsByYear W20315675022014 @default.
- W2031567502 countsByYear W20315675022015 @default.
- W2031567502 countsByYear W20315675022016 @default.
- W2031567502 countsByYear W20315675022017 @default.
- W2031567502 countsByYear W20315675022018 @default.
- W2031567502 countsByYear W20315675022020 @default.
- W2031567502 crossrefType "journal-article" @default.
- W2031567502 hasAuthorship W2031567502A5008003570 @default.
- W2031567502 hasAuthorship W2031567502A5010525884 @default.
- W2031567502 hasAuthorship W2031567502A5039655833 @default.
- W2031567502 hasAuthorship W2031567502A5040046754 @default.
- W2031567502 hasAuthorship W2031567502A5046506553 @default.
- W2031567502 hasAuthorship W2031567502A5046757453 @default.
- W2031567502 hasAuthorship W2031567502A5059195352 @default.
- W2031567502 hasAuthorship W2031567502A5064494964 @default.
- W2031567502 hasAuthorship W2031567502A5069065380 @default.
- W2031567502 hasAuthorship W2031567502A5076022267 @default.
- W2031567502 hasAuthorship W2031567502A5080215605 @default.
- W2031567502 hasAuthorship W2031567502A5081432607 @default.
- W2031567502 hasAuthorship W2031567502A5085142320 @default.
- W2031567502 hasAuthorship W2031567502A5089497139 @default.
- W2031567502 hasConcept C126322002 @default.
- W2031567502 hasConcept C134018914 @default.
- W2031567502 hasConcept C171089720 @default.
- W2031567502 hasConcept C176891718 @default.
- W2031567502 hasConcept C185592680 @default.
- W2031567502 hasConcept C202751555 @default.
- W2031567502 hasConcept C2776175234 @default.
- W2031567502 hasConcept C2776175330 @default.
- W2031567502 hasConcept C2776200302 @default.