FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031569270> ?p ?o ?g. }

• W2031569270 endingPage "1195" @default.
• W2031569270 startingPage "1189" @default.
• W2031569270 abstract "The authors evaluated the presence of somatostatin (SRIF) in the plasma and in the tumor tissue of a total of 22 patients with medullary thyroid cancer (MTC) and studied the effect of exogenous SRIF administration on basal and pentagastrin (PG)-stimulated plasma calcitonin (CT) and carcinoembrionic antigen (CEA) levels. Mean plasma SRIF concentrations were significantly higher than those found in normal controls, with five of 15 patients having plasma SRIF levels above the mean + 2 SD of normal controls. High immunoreactive SRIF concentrations were found in the extract of three tumor tissues but not in one follicular thyroid cancer or in one toxic diffuse goiter. By immunoperoxidase staining seven of 11 (63.6%) primary MTC and five of 13 (38.5%) metastases expressed SRIF antigen in a low number of cells and with a weak degree of staining. As expected, CT was expressed in almost 100% of the cases with positivity in most of the cells and strong degree of staining. Patients with positive SRIF staining in the primary tumor had longer survival than SRIF negative patients. Infusion of synthetic SRIF (11 μg/minute/45 minutes) produced a significant reduction of plasma CT (but not CEA) levels in 12 of the 15 patients submitted to this test. Maximal percent decrease of plasma CT ranged from 10.8% to 72.7% of the basal value and was usually observed between 30 and 45 minutes from the beginning of the infusion. When infused together with the injection of PG, SRIF was able to significantly (P < 0.05) inhibit the PG-induced CT release in five of six patients tested. These results demonstrate the following: SRIF is present in a few cells of many primary MTC and less frequently in their metastases; tentatively, the expression of SRIF antigen in the tumor seems to be associated with longer survival; increased SRIF concentrations are found in the plasma of some patients with metastatic involvement; and treatment with exogenous SRIF reduces the basal and PG-induced CT (but not CEA) release from the tumor." @default.
• W2031569270 created "2016-06-24" @default.
• W2031569270 creator A5014279456 @default.
• W2031569270 creator A5018404791 @default.
• W2031569270 creator A5027117186 @default.
• W2031569270 creator A5042554617 @default.
• W2031569270 creator A5060902293 @default.
• W2031569270 creator A5083770629 @default.
• W2031569270 date "1989-03-15" @default.
• W2031569270 modified "2023-10-04" @default.
• W2031569270 title "Somatostatin in medullary thyroid cancer.In vitro andin vivo studies" @default.
• W2031569270 cites W118223589 @default.
• W2031569270 cites W1597763689 @default.
• W2031569270 cites W1899238028 @default.
• W2031569270 cites W1963833809 @default.
• W2031569270 cites W1964747228 @default.
• W2031569270 cites W1967671925 @default.
• W2031569270 cites W1971334246 @default.
• W2031569270 cites W1975707095 @default.
• W2031569270 cites W1977847069 @default.
• W2031569270 cites W1986674177 @default.
• W2031569270 cites W1988047194 @default.
• W2031569270 cites W1996876777 @default.
• W2031569270 cites W2009059575 @default.
• W2031569270 cites W2010889753 @default.
• W2031569270 cites W2015609597 @default.
• W2031569270 cites W2016168483 @default.
• W2031569270 cites W2028413137 @default.
• W2031569270 cites W2031410788 @default.
• W2031569270 cites W2033976980 @default.
• W2031569270 cites W2046187870 @default.
• W2031569270 cites W2055187212 @default.
• W2031569270 cites W2055961659 @default.
• W2031569270 cites W2057289630 @default.
• W2031569270 cites W2061799861 @default.
• W2031569270 cites W2071310612 @default.
• W2031569270 cites W2076685145 @default.
• W2031569270 cites W2077263112 @default.
• W2031569270 cites W2088469503 @default.
• W2031569270 cites W2089901924 @default.
• W2031569270 cites W2091301980 @default.
• W2031569270 cites W2092759696 @default.
• W2031569270 cites W2110908962 @default.
• W2031569270 cites W2136418839 @default.
• W2031569270 cites W2144366138 @default.
• W2031569270 cites W2161504149 @default.
• W2031569270 cites W2163966674 @default.
• W2031569270 cites W2168498803 @default.
• W2031569270 cites W2320385819 @default.
• W2031569270 cites W2338127063 @default.
• W2031569270 doi "https://doi.org/10.1002/1097-0142(19890315)63:6<1189::aid-cncr2820630625>3.0.co;2-j" @default.
• W2031569270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2563668" @default.
• W2031569270 hasPublicationYear "1989" @default.
• W2031569270 type Work @default.
• W2031569270 sameAs 2031569270 @default.
• W2031569270 citedByCount "42" @default.
• W2031569270 countsByYear W20315692702015 @default.
• W2031569270 countsByYear W20315692702016 @default.
• W2031569270 countsByYear W20315692702017 @default.
• W2031569270 countsByYear W20315692702023 @default.
• W2031569270 crossrefType "journal-article" @default.
• W2031569270 hasAuthorship W2031569270A5014279456 @default.
• W2031569270 hasAuthorship W2031569270A5018404791 @default.
• W2031569270 hasAuthorship W2031569270A5027117186 @default.
• W2031569270 hasAuthorship W2031569270A5042554617 @default.
• W2031569270 hasAuthorship W2031569270A5060902293 @default.
• W2031569270 hasAuthorship W2031569270A5083770629 @default.
• W2031569270 hasBestOaLocation W20315692701 @default.
• W2031569270 hasConcept C126322002 @default.
• W2031569270 hasConcept C134018914 @default.
• W2031569270 hasConcept C142724271 @default.
• W2031569270 hasConcept C150903083 @default.
• W2031569270 hasConcept C207001950 @default.
• W2031569270 hasConcept C2776297358 @default.
• W2031569270 hasConcept C2778024521 @default.
• W2031569270 hasConcept C2779306644 @default.
• W2031569270 hasConcept C2779627488 @default.
• W2031569270 hasConcept C2779761222 @default.
• W2031569270 hasConcept C2780120053 @default.
• W2031569270 hasConcept C526584372 @default.
• W2031569270 hasConcept C71924100 @default.
• W2031569270 hasConcept C74864618 @default.
• W2031569270 hasConcept C86803240 @default.
• W2031569270 hasConceptScore W2031569270C126322002 @default.
• W2031569270 hasConceptScore W2031569270C134018914 @default.
• W2031569270 hasConceptScore W2031569270C142724271 @default.
• W2031569270 hasConceptScore W2031569270C150903083 @default.
• W2031569270 hasConceptScore W2031569270C207001950 @default.
• W2031569270 hasConceptScore W2031569270C2776297358 @default.
• W2031569270 hasConceptScore W2031569270C2778024521 @default.
• W2031569270 hasConceptScore W2031569270C2779306644 @default.
• W2031569270 hasConceptScore W2031569270C2779627488 @default.
• W2031569270 hasConceptScore W2031569270C2779761222 @default.
• W2031569270 hasConceptScore W2031569270C2780120053 @default.
• W2031569270 hasConceptScore W2031569270C526584372 @default.
• W2031569270 hasConceptScore W2031569270C71924100 @default.
• W2031569270 hasConceptScore W2031569270C74864618 @default.
• W2031569270 hasConceptScore W2031569270C86803240 @default.

• next