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- W2031574356 abstract "Two neutral steroid-transforming activities were demonstrated in cell extracts of Clostridium scindens. Steroid-17–20-desmolase and 20α-hydroxysteroid dehydrogenase were found to be inducible in cells cultured in the presence of Cortisol. Both activities required manganese ions and NAD + or NADH for activity. Cortisol, cortisone and 11-desoxycortisol were substrates as well as induce of steroid-17–20-desmolase and 20α-hydroxysteroid dehydrogenase activities. 17α-Hydroxyprogesterone was an effective inducer but did not serve as a substrate for either enzyme activity. C. scindens is the first bacterial species of the normal human intestinal flora reported to elaborate inducible steroid-17–20-desmolase and 20α-hydroxysteroid dehydrogenase activities. The results of cofactor, substrate specificity and induction studies suggest that these two activities may reside in the same enzyme complex." @default.
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- W2031574356 date "1987-07-01" @default.
- W2031574356 modified "2023-10-16" @default.
- W2031574356 title "Cofactor requirements of steroid- 17-20-desmolase and 20α-hydroxysteroid dehydrogenase activities in cell extracts of Clostridium scindens" @default.
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- W2031574356 doi "https://doi.org/10.1016/0022-4731(87)90123-3" @default.
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