Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031621476> ?p ?o ?g. }
- W2031621476 endingPage "17192" @default.
- W2031621476 startingPage "17180" @default.
- W2031621476 abstract "Ascorbic acid (vitamin C) is necessary for myelination of Schwann cell/neuron cocultures and has shown beneficial effects in the treatment of a Charcot-Marie-Tooth neuropathy 1A (CMT1A) mouse model. Although clinical studies revealed that ascorbic acid treatment had no impact on CMT1A, it is assumed to have an important function in peripheral nerve myelination and possibly in remyelination. However, the transport pathway of ascorbic acid into peripheral nerves and the mechanism of ascorbic acid function in peripheral nerves in vivo remained unclear. In this study, we used sodium-dependent vitamin C transporter 2-heterozygous (SVCT2 +/− ) mice to elucidate the functions of SVCT2 and ascorbic acid in the murine peripheral nervous system. SVCT2 and ascorbic acid levels were reduced in SVCT2 +/− peripheral nerves. Morphometry of sciatic nerve fibers revealed a decrease in myelin thickness and an increase in G-ratios in SVCT2 +/− mice. Nerve conduction velocities and sensorimotor performance in functional tests were reduced in SVCT2 +/− mice. To investigate the mechanism of ascorbic acid function, we studied the expression of collagens in the extracellular matrix of peripheral nerves. Here, we show that expression of various collagen types was reduced in sciatic nerves of SVCT2 +/− mice. We found that collagen gene transcription was reduced in SVCT2 +/− mice but hydroxyproline levels were not, indicating that collagen formation was regulated on the transcriptional and not the posttranslational level. These results help to clarify the transport pathway and mechanism of action of ascorbic acid in the peripheral nervous system and may lead to novel therapeutic approaches to peripheral neuropathies by manipulation of SVCT2 function." @default.
- W2031621476 created "2016-06-24" @default.
- W2031621476 creator A5008389867 @default.
- W2031621476 creator A5012284378 @default.
- W2031621476 creator A5021942776 @default.
- W2031621476 creator A5025432657 @default.
- W2031621476 creator A5027194892 @default.
- W2031621476 creator A5036637334 @default.
- W2031621476 creator A5053757071 @default.
- W2031621476 creator A5057456072 @default.
- W2031621476 creator A5075094490 @default.
- W2031621476 creator A5088683724 @default.
- W2031621476 date "2011-11-23" @default.
- W2031621476 modified "2023-10-14" @default.
- W2031621476 title "Sodium-Dependent Vitamin C Transporter 2 Deficiency Causes Hypomyelination and Extracellular Matrix Defects in the Peripheral Nervous System" @default.
- W2031621476 cites W1564950177 @default.
- W2031621476 cites W1591265240 @default.
- W2031621476 cites W1900028828 @default.
- W2031621476 cites W1909061788 @default.
- W2031621476 cites W1965714383 @default.
- W2031621476 cites W1969385847 @default.
- W2031621476 cites W1971776337 @default.
- W2031621476 cites W1973602321 @default.
- W2031621476 cites W1973686473 @default.
- W2031621476 cites W1976921928 @default.
- W2031621476 cites W1978361666 @default.
- W2031621476 cites W1978966509 @default.
- W2031621476 cites W1979221090 @default.
- W2031621476 cites W1980433493 @default.
- W2031621476 cites W1982272270 @default.
- W2031621476 cites W1982659220 @default.
- W2031621476 cites W1986361477 @default.
- W2031621476 cites W1987614487 @default.
- W2031621476 cites W1991799838 @default.
- W2031621476 cites W1999465923 @default.
- W2031621476 cites W2004460833 @default.
- W2031621476 cites W2018664741 @default.
- W2031621476 cites W2022726875 @default.
- W2031621476 cites W2028817794 @default.
- W2031621476 cites W2031058166 @default.
- W2031621476 cites W2034462747 @default.
- W2031621476 cites W2037717316 @default.
- W2031621476 cites W2042062434 @default.
- W2031621476 cites W2042784458 @default.
- W2031621476 cites W2042967985 @default.
- W2031621476 cites W2047992983 @default.
- W2031621476 cites W2055628878 @default.
- W2031621476 cites W2059853747 @default.
- W2031621476 cites W2064481190 @default.
- W2031621476 cites W2064588350 @default.
- W2031621476 cites W2065549871 @default.
- W2031621476 cites W2067089499 @default.
- W2031621476 cites W2076562512 @default.
- W2031621476 cites W2082176618 @default.
- W2031621476 cites W2088939395 @default.
- W2031621476 cites W2089773021 @default.
- W2031621476 cites W2097318813 @default.
- W2031621476 cites W2099249565 @default.
- W2031621476 cites W2102244428 @default.
- W2031621476 cites W2102718676 @default.
- W2031621476 cites W2107334796 @default.
- W2031621476 cites W2108244474 @default.
- W2031621476 cites W2163960353 @default.
- W2031621476 cites W2170854435 @default.
- W2031621476 cites W2493446116 @default.
- W2031621476 cites W4249374289 @default.
- W2031621476 doi "https://doi.org/10.1523/jneurosci.3457-11.2011" @default.
- W2031621476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6623846" @default.
- W2031621476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22114285" @default.
- W2031621476 hasPublicationYear "2011" @default.
- W2031621476 type Work @default.
- W2031621476 sameAs 2031621476 @default.
- W2031621476 citedByCount "38" @default.
- W2031621476 countsByYear W20316214762012 @default.
- W2031621476 countsByYear W20316214762013 @default.
- W2031621476 countsByYear W20316214762014 @default.
- W2031621476 countsByYear W20316214762015 @default.
- W2031621476 countsByYear W20316214762016 @default.
- W2031621476 countsByYear W20316214762017 @default.
- W2031621476 countsByYear W20316214762018 @default.
- W2031621476 countsByYear W20316214762019 @default.
- W2031621476 countsByYear W20316214762020 @default.
- W2031621476 countsByYear W20316214762021 @default.
- W2031621476 countsByYear W20316214762022 @default.
- W2031621476 crossrefType "journal-article" @default.
- W2031621476 hasAuthorship W2031621476A5008389867 @default.
- W2031621476 hasAuthorship W2031621476A5012284378 @default.
- W2031621476 hasAuthorship W2031621476A5021942776 @default.
- W2031621476 hasAuthorship W2031621476A5025432657 @default.
- W2031621476 hasAuthorship W2031621476A5027194892 @default.
- W2031621476 hasAuthorship W2031621476A5036637334 @default.
- W2031621476 hasAuthorship W2031621476A5053757071 @default.
- W2031621476 hasAuthorship W2031621476A5057456072 @default.
- W2031621476 hasAuthorship W2031621476A5075094490 @default.
- W2031621476 hasAuthorship W2031621476A5088683724 @default.
- W2031621476 hasBestOaLocation W20316214761 @default.
- W2031621476 hasConcept C105702510 @default.
- W2031621476 hasConcept C126322002 @default.