FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031624140> ?p ?o ?g. }

• W2031624140 endingPage "816" @default.
• W2031624140 startingPage "809" @default.
• W2031624140 abstract "A deficient regulation of neuronal cytosolic calcium levels has been suggested to play a role in the pathogenesis of neurodegeneration. However, evidence for an alteration in cytosolic calcium regulation in old age is at present controversial. The present work was aimed at studying whether changes in synaptosomal calcium homeostasis in 30-month-old rats are uniform throughout the brain or affect specific brain regions. A second question addressed in this work is whether the effect of ageing on calcium homeostasis is restricted to the nerve terminal or a more general process affecting also cell bodies. To study these questions cytosolic calcium regulation was studied in parallel in synaptosomes and a preparation of acutely dissociated brain cells obtained from different regions of 3- and 30-month-old rats. 45Ca2+ accumulation and distribution in mitochondria (assessed as FCCP-releasable 45Ca2+) was also studied. Mean [Ca2+]i obtained at rest and after high K+ depolarization were unchanged in cerebral cortex synaptosomes but increased in hippocampal synaptosomes at 30 months. Resting [Ca2+]i also increased with age in hippocampal, but not cerebral cortex cells, whereas the increase in [Ca2+]i obtained by depolarization was larger in both brain regions. Calcium compartmentation in mitochondria from hippocampal neurons incubated under high K+ conditions was also decreased with ageing. An altered calcium regulation in cell bodies and synaptic terminals in the hippocampus may be involved in the development of functional impairments in the hippocampal formation." @default.
• W2031624140 created "2016-06-24" @default.
• W2031624140 creator A5002453287 @default.
• W2031624140 creator A5034720125 @default.
• W2031624140 creator A5049038086 @default.
• W2031624140 creator A5053346430 @default.
• W2031624140 date "1995-09-01" @default.
• W2031624140 modified "2023-10-18" @default.
• W2031624140 title "Altered cell calcium regulation in synaptosomes and brain cells of the 30-month-old rat: Prominent effects in hippocampus" @default.
• W2031624140 cites W1563012002 @default.
• W2031624140 cites W1564797650 @default.
• W2031624140 cites W1575800126 @default.
• W2031624140 cites W1604419938 @default.
• W2031624140 cites W162990493 @default.
• W2031624140 cites W1684853394 @default.
• W2031624140 cites W1969736263 @default.
• W2031624140 cites W1978084060 @default.
• W2031624140 cites W1980678715 @default.
• W2031624140 cites W1981662118 @default.
• W2031624140 cites W1983605468 @default.
• W2031624140 cites W1984097693 @default.
• W2031624140 cites W1986552593 @default.
• W2031624140 cites W1987607342 @default.
• W2031624140 cites W1991192746 @default.
• W2031624140 cites W1992633472 @default.
• W2031624140 cites W1993920298 @default.
• W2031624140 cites W1994802043 @default.
• W2031624140 cites W1996937956 @default.
• W2031624140 cites W1997945837 @default.
• W2031624140 cites W1999304520 @default.
• W2031624140 cites W2002264389 @default.
• W2031624140 cites W2015594566 @default.
• W2031624140 cites W2022777861 @default.
• W2031624140 cites W2025392898 @default.
• W2031624140 cites W2030806909 @default.
• W2031624140 cites W2043109020 @default.
• W2031624140 cites W2044955649 @default.
• W2031624140 cites W2053457664 @default.
• W2031624140 cites W2059651493 @default.
• W2031624140 cites W2068996010 @default.
• W2031624140 cites W2069859544 @default.
• W2031624140 cites W2074476302 @default.
• W2031624140 cites W2075308892 @default.
• W2031624140 cites W2091724344 @default.
• W2031624140 cites W2094761935 @default.
• W2031624140 cites W2103861118 @default.
• W2031624140 cites W2137355173 @default.
• W2031624140 doi "https://doi.org/10.1016/0197-4580(95)00087-u" @default.
• W2031624140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8532115" @default.
• W2031624140 hasPublicationYear "1995" @default.
• W2031624140 type Work @default.
• W2031624140 sameAs 2031624140 @default.
• W2031624140 citedByCount "36" @default.
• W2031624140 countsByYear W20316241402012 @default.
• W2031624140 countsByYear W20316241402013 @default.
• W2031624140 countsByYear W20316241402014 @default.
• W2031624140 countsByYear W20316241402015 @default.
• W2031624140 countsByYear W20316241402016 @default.
• W2031624140 countsByYear W20316241402017 @default.
• W2031624140 countsByYear W20316241402020 @default.
• W2031624140 crossrefType "journal-article" @default.
• W2031624140 hasAuthorship W2031624140A5002453287 @default.
• W2031624140 hasAuthorship W2031624140A5034720125 @default.
• W2031624140 hasAuthorship W2031624140A5049038086 @default.
• W2031624140 hasAuthorship W2031624140A5053346430 @default.
• W2031624140 hasConcept C126322002 @default.
• W2031624140 hasConcept C134018914 @default.
• W2031624140 hasConcept C148762608 @default.
• W2031624140 hasConcept C169760540 @default.
• W2031624140 hasConcept C181199279 @default.
• W2031624140 hasConcept C185592680 @default.
• W2031624140 hasConcept C2776925932 @default.
• W2031624140 hasConcept C2778921374 @default.
• W2031624140 hasConcept C2779134260 @default.
• W2031624140 hasConcept C2781041448 @default.
• W2031624140 hasConcept C2781161787 @default.
• W2031624140 hasConcept C4141045 @default.
• W2031624140 hasConcept C519063684 @default.
• W2031624140 hasConcept C529278444 @default.
• W2031624140 hasConcept C55493867 @default.
• W2031624140 hasConcept C71924100 @default.
• W2031624140 hasConcept C86803240 @default.
• W2031624140 hasConcept C87975464 @default.
• W2031624140 hasConcept C98539663 @default.
• W2031624140 hasConceptScore W2031624140C126322002 @default.
• W2031624140 hasConceptScore W2031624140C134018914 @default.
• W2031624140 hasConceptScore W2031624140C148762608 @default.
• W2031624140 hasConceptScore W2031624140C169760540 @default.
• W2031624140 hasConceptScore W2031624140C181199279 @default.
• W2031624140 hasConceptScore W2031624140C185592680 @default.
• W2031624140 hasConceptScore W2031624140C2776925932 @default.
• W2031624140 hasConceptScore W2031624140C2778921374 @default.
• W2031624140 hasConceptScore W2031624140C2779134260 @default.
• W2031624140 hasConceptScore W2031624140C2781041448 @default.
• W2031624140 hasConceptScore W2031624140C2781161787 @default.
• W2031624140 hasConceptScore W2031624140C4141045 @default.
• W2031624140 hasConceptScore W2031624140C519063684 @default.
• W2031624140 hasConceptScore W2031624140C529278444 @default.

• next