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- W2031636581 abstract "The pH i regulation from intracellular acidosis in the central nervous system appears to be mediated by mechanisms driven by the large inwardly directed Na + gradient. The involvement of these mechanisms in pH i regulation of neurones and glial cells has been investigated in the leech central nervous system using ion-selective microelectrodes. For recovery from acidification, there appear to be three separate mechanisms: Na + /H + exchange, Na + -dependent Cl − /HCO 3 − exchange, and Na + –HCO 3 − cotransport. All three mechanisms have a profound effect on the maintenance of pH i homeostasis in glial ceils; whereas in leech neurones, as in other neuronal cells studied previously, the predominant mechanisms are Na + /H + and Na + -dependent Cl − /HCO 3 − exchange. In addition to acid extrusion mechanisms we also found evidence for Na + -independent Cl − /HCO 3 − exchange. At alkaline pH i this exchanger may mediate some of the pH i recovery from intracellular alkalinization.Key words: central nervous system, pH regulation, neurotransmitter." @default.
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- W2031636581 date "1992-05-15" @default.
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- W2031636581 title "The regulation of pH in the central nervous system" @default.
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- W2031636581 doi "https://doi.org/10.1139/y92-273" @default.
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