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• W2031640265 abstract "Ropivacaine, a novel long-acting local anesthetic, has been proved to own superior advantage. However, Naropin® Injection, the applied form in clinic, can cause patient non-convenience. The purpose of this study was to formulate ropivacaine (RPV) in ethosomes and evaluate the potential of ethosome formulation in delivering RPV transdermally. The RPV-loaded ethosomes were prepared with thin-film dispersion technique and the formulation was characterized in terms of size, zeta potential, differential scanning calorimetry (DSC) analysis and X-ray diffraction (XRD) study. The results showed that the optimized RPV-ethosomes displayed a typical lipid bilayer structure with a narrow size distribution of 73.86 ± 2.40 nm and drug loading of 8.27 ± 0.37%, EE of 68.92 ± 0.29%. The results of DSC and XRD study indicated that RPV was in amorphous state when encapsulated into ethosomes. Furthermore, the results of ex vivo permeation study proved that RPV-ethosomes could promote the permeability in a high-efficient, rapid way (349.0 ± 11.5 μg cm(-2) at 12 h and 178.8 ± 7.1 μg cm(-2) at 0.5 h). The outcomes of histopathology study forecasted that the interaction between ethosomes and skin could loosen the tight conjugation of corneocyte layers and weaken the permeation barrier. In conclusion, RPV-ethosomes could be a promising delivery system to encapsulate RPV and deliver RPV for transdermal administration." @default.
• W2031640265 created "2016-06-24" @default.
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• W2031640265 date "2015-01-27" @default.
• W2031640265 modified "2023-10-16" @default.
• W2031640265 title "Ethosomes for skin delivery of ropivacaine: preparation, characterization and<i>ex vivo</i>penetration properties" @default.
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• W2031640265 doi "https://doi.org/10.3109/08982104.2014.999686" @default.
• W2031640265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25625544" @default.
• W2031640265 hasPublicationYear "2015" @default.
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