Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031640807> ?p ?o ?g. }
- W2031640807 endingPage "266" @default.
- W2031640807 startingPage "257" @default.
- W2031640807 abstract "Multidrug resistance (MDR) mediated by P-glycoprotein overexpression in solid tumors is a major factor in the failure of many forms of chemotherapy. Here we evaluated phospholipid-modified, low-molecular-weight polyethylenimine (DOPE-PEI) nanocarriers for intravenous delivery of anti-P-pg siRNA to tumors with the final goal of modulating MDR in breast cancer. First, we studied the biodistribution of DOPE-PEI nanocarriers and the effect of PEG coating in a subcutaneous breast tumor model. Four hours postinjection, PEGylated carriers showed an 8% injected dose (ID) accumulation in solid tumor via the enhanced permeability and retention effect and 22% ID in serum due to a prolonged, PEG-mediated circulation. Second, we established the therapeutic efficacy and safety of DOPE-PEI/siRNA-mediated P-gp downregulation in combination with doxorubicin (Dox) chemotherapy in MCF-7/MDR xenografts. Weekly injection of siRNA nanopreparations and Dox for up to 5 weeks sensitized the tumors to otherwise non-effective doses of Dox and decreased the tumor volume by threefold vs controls. This therapeutic improvement in response to Dox was attributed to the significant, sequence-specific P-gp downregulation in excised tumors mediated by the DOPE-PEI formulations." @default.
- W2031640807 created "2016-06-24" @default.
- W2031640807 creator A5014576744 @default.
- W2031640807 creator A5022538301 @default.
- W2031640807 creator A5022630402 @default.
- W2031640807 creator A5038150974 @default.
- W2031640807 creator A5046088470 @default.
- W2031640807 creator A5052835685 @default.
- W2031640807 creator A5084391530 @default.
- W2031640807 date "2014-10-30" @default.
- W2031640807 modified "2023-10-14" @default.
- W2031640807 title "Phospholipid-modified PEI-based nanocarriers for in vivo siRNA therapeutics against multidrug-resistant tumors" @default.
- W2031640807 cites W120814930 @default.
- W2031640807 cites W1963837352 @default.
- W2031640807 cites W1968263631 @default.
- W2031640807 cites W1972461780 @default.
- W2031640807 cites W1978271981 @default.
- W2031640807 cites W1983075730 @default.
- W2031640807 cites W1983577609 @default.
- W2031640807 cites W1983718760 @default.
- W2031640807 cites W1984739176 @default.
- W2031640807 cites W1985241728 @default.
- W2031640807 cites W1989611595 @default.
- W2031640807 cites W1998348474 @default.
- W2031640807 cites W2002950604 @default.
- W2031640807 cites W2003006200 @default.
- W2031640807 cites W2004122590 @default.
- W2031640807 cites W2010281379 @default.
- W2031640807 cites W2010854970 @default.
- W2031640807 cites W2013270956 @default.
- W2031640807 cites W2019769726 @default.
- W2031640807 cites W2020904161 @default.
- W2031640807 cites W2021385919 @default.
- W2031640807 cites W2027515501 @default.
- W2031640807 cites W2029983315 @default.
- W2031640807 cites W2031493200 @default.
- W2031640807 cites W2032167680 @default.
- W2031640807 cites W2036151735 @default.
- W2031640807 cites W2037048276 @default.
- W2031640807 cites W2041294276 @default.
- W2031640807 cites W2042233059 @default.
- W2031640807 cites W2049772927 @default.
- W2031640807 cites W2051950678 @default.
- W2031640807 cites W2060571263 @default.
- W2031640807 cites W2067302150 @default.
- W2031640807 cites W2069651638 @default.
- W2031640807 cites W2069879613 @default.
- W2031640807 cites W2073311119 @default.
- W2031640807 cites W2074049796 @default.
- W2031640807 cites W2074133546 @default.
- W2031640807 cites W2076295610 @default.
- W2031640807 cites W2078377919 @default.
- W2031640807 cites W2079445254 @default.
- W2031640807 cites W2080071319 @default.
- W2031640807 cites W2095571709 @default.
- W2031640807 cites W2096491309 @default.
- W2031640807 cites W2096814286 @default.
- W2031640807 cites W2096908318 @default.
- W2031640807 cites W2098934895 @default.
- W2031640807 cites W2100596948 @default.
- W2031640807 cites W2110976740 @default.
- W2031640807 cites W2116162518 @default.
- W2031640807 cites W2116385570 @default.
- W2031640807 cites W2118085243 @default.
- W2031640807 cites W2118844383 @default.
- W2031640807 cites W2121649418 @default.
- W2031640807 cites W2124454872 @default.
- W2031640807 cites W2143026251 @default.
- W2031640807 cites W2150702593 @default.
- W2031640807 cites W2168045030 @default.
- W2031640807 cites W2171467310 @default.
- W2031640807 cites W2412450279 @default.
- W2031640807 cites W4042391 @default.
- W2031640807 cites W84182309 @default.
- W2031640807 cites W8603682 @default.
- W2031640807 doi "https://doi.org/10.1038/gt.2014.97" @default.
- W2031640807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4352110" @default.
- W2031640807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25354685" @default.
- W2031640807 hasPublicationYear "2014" @default.
- W2031640807 type Work @default.
- W2031640807 sameAs 2031640807 @default.
- W2031640807 citedByCount "60" @default.
- W2031640807 countsByYear W20316408072015 @default.
- W2031640807 countsByYear W20316408072016 @default.
- W2031640807 countsByYear W20316408072017 @default.
- W2031640807 countsByYear W20316408072018 @default.
- W2031640807 countsByYear W20316408072019 @default.
- W2031640807 countsByYear W20316408072020 @default.
- W2031640807 countsByYear W20316408072021 @default.
- W2031640807 countsByYear W20316408072022 @default.
- W2031640807 countsByYear W20316408072023 @default.
- W2031640807 crossrefType "journal-article" @default.
- W2031640807 hasAuthorship W2031640807A5014576744 @default.
- W2031640807 hasAuthorship W2031640807A5022538301 @default.
- W2031640807 hasAuthorship W2031640807A5022630402 @default.
- W2031640807 hasAuthorship W2031640807A5038150974 @default.
- W2031640807 hasAuthorship W2031640807A5046088470 @default.
- W2031640807 hasAuthorship W2031640807A5052835685 @default.