Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031647524> ?p ?o ?g. }
- W2031647524 endingPage "129" @default.
- W2031647524 startingPage "119" @default.
- W2031647524 abstract "Knockout of genes encoding metabotropic glutamate receptor 5 (mGluR5) or its endogenous regulators, such as Norbin, induce a schizophrenia-like phenotype in rodents, suggesting dysregulation of mGluR5 in schizophrenia. Human genetic and pharmacological animal studies support this hypothesis, but no studies have explored mGluR5 dysfunction at the molecular level in the postmortem schizophrenia brain. We assessed mGluR5 mRNA and protein levels in the dorsolateral prefrontal cortex (DLPFC) using a large cohort of schizophrenia and control subjects (n = 37/group), and additionally measured protein levels of recently discovered mGluR5 endogenous regulators, Norbin (neurochondrin), Tamalin (GRASP-1), and Preso1 (FRMPD4), which regulate mGluR5 localization, internalization and signaling. While mGluR5 mRNA expression was unchanged, mGluR5 protein levels were significantly higher in schizophrenia subjects compared to controls (total: +22 %; dimer: +54 %; p < 0.001). Conversely, mGluR5 regulatory proteins were expressed at lower levels in schizophrenia subjects compared to controls (Norbin −37 %, p < 0.001; Tamalin −30 %, p = 0.084; Preso1 −29 %, p = 0.001). mGluR5 protein was significantly associated with mGluR5 mRNA and mGluR5 endogenous regulators in control subjects, but these associations were lost in schizophrenia subjects. Lastly, there were no associations between protein measures and lifetime antipsychotic history in schizophrenia subjects. To confirm no antipsychotic influence, all proteins were measured in the prefrontal cortex of rats exposed to haloperidol or olanzapine; there were no effects of antipsychotic drug treatment on mGluR5, Norbin, Tamalin or Preso1. The results from our study provide compelling evidence that mGluR5 regulation is altered in schizophrenia, likely contributing to the altered glutamatergic signaling that is associated with the disorder." @default.
- W2031647524 created "2016-06-24" @default.
- W2031647524 creator A5002681207 @default.
- W2031647524 creator A5006094576 @default.
- W2031647524 creator A5012808698 @default.
- W2031647524 creator A5045863890 @default.
- W2031647524 creator A5046354591 @default.
- W2031647524 creator A5060055772 @default.
- W2031647524 creator A5069495397 @default.
- W2031647524 creator A5086647895 @default.
- W2031647524 creator A5086950665 @default.
- W2031647524 date "2015-03-17" @default.
- W2031647524 modified "2023-10-18" @default.
- W2031647524 title "Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation" @default.
- W2031647524 cites W1964320873 @default.
- W2031647524 cites W1980628262 @default.
- W2031647524 cites W1982939523 @default.
- W2031647524 cites W2000526380 @default.
- W2031647524 cites W2002090384 @default.
- W2031647524 cites W2007051067 @default.
- W2031647524 cites W2023159509 @default.
- W2031647524 cites W2024278971 @default.
- W2031647524 cites W2032503223 @default.
- W2031647524 cites W2047931198 @default.
- W2031647524 cites W2049157592 @default.
- W2031647524 cites W2053816443 @default.
- W2031647524 cites W2053842655 @default.
- W2031647524 cites W2053938654 @default.
- W2031647524 cites W2058934183 @default.
- W2031647524 cites W2061608089 @default.
- W2031647524 cites W2061965299 @default.
- W2031647524 cites W2062609055 @default.
- W2031647524 cites W2063759211 @default.
- W2031647524 cites W2064086445 @default.
- W2031647524 cites W2075709680 @default.
- W2031647524 cites W2084722042 @default.
- W2031647524 cites W2107363136 @default.
- W2031647524 cites W2111962217 @default.
- W2031647524 cites W2115723482 @default.
- W2031647524 cites W2124506172 @default.
- W2031647524 cites W2129244109 @default.
- W2031647524 cites W2136472480 @default.
- W2031647524 cites W2136672278 @default.
- W2031647524 cites W2139078690 @default.
- W2031647524 cites W2145492531 @default.
- W2031647524 cites W2149418167 @default.
- W2031647524 cites W2156653705 @default.
- W2031647524 cites W2162583663 @default.
- W2031647524 cites W2164769240 @default.
- W2031647524 cites W2165533815 @default.
- W2031647524 cites W2166318379 @default.
- W2031647524 cites W2322769816 @default.
- W2031647524 doi "https://doi.org/10.1007/s00401-015-1411-6" @default.
- W2031647524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25778620" @default.
- W2031647524 hasPublicationYear "2015" @default.
- W2031647524 type Work @default.
- W2031647524 sameAs 2031647524 @default.
- W2031647524 citedByCount "36" @default.
- W2031647524 countsByYear W20316475242015 @default.
- W2031647524 countsByYear W20316475242016 @default.
- W2031647524 countsByYear W20316475242017 @default.
- W2031647524 countsByYear W20316475242018 @default.
- W2031647524 countsByYear W20316475242019 @default.
- W2031647524 countsByYear W20316475242020 @default.
- W2031647524 countsByYear W20316475242021 @default.
- W2031647524 countsByYear W20316475242022 @default.
- W2031647524 countsByYear W20316475242023 @default.
- W2031647524 crossrefType "journal-article" @default.
- W2031647524 hasAuthorship W2031647524A5002681207 @default.
- W2031647524 hasAuthorship W2031647524A5006094576 @default.
- W2031647524 hasAuthorship W2031647524A5012808698 @default.
- W2031647524 hasAuthorship W2031647524A5045863890 @default.
- W2031647524 hasAuthorship W2031647524A5046354591 @default.
- W2031647524 hasAuthorship W2031647524A5060055772 @default.
- W2031647524 hasAuthorship W2031647524A5069495397 @default.
- W2031647524 hasAuthorship W2031647524A5086647895 @default.
- W2031647524 hasAuthorship W2031647524A5086950665 @default.
- W2031647524 hasBestOaLocation W20316475242 @default.
- W2031647524 hasConcept C118552586 @default.
- W2031647524 hasConcept C126322002 @default.
- W2031647524 hasConcept C15744967 @default.
- W2031647524 hasConcept C169760540 @default.
- W2031647524 hasConcept C170493617 @default.
- W2031647524 hasConcept C195794163 @default.
- W2031647524 hasConcept C2776412080 @default.
- W2031647524 hasConcept C2780748493 @default.
- W2031647524 hasConcept C41653306 @default.
- W2031647524 hasConcept C49051014 @default.
- W2031647524 hasConcept C61174792 @default.
- W2031647524 hasConcept C62478195 @default.
- W2031647524 hasConcept C71924100 @default.
- W2031647524 hasConcept C86803240 @default.
- W2031647524 hasConcept C95444343 @default.
- W2031647524 hasConcept C98274493 @default.
- W2031647524 hasConceptScore W2031647524C118552586 @default.
- W2031647524 hasConceptScore W2031647524C126322002 @default.
- W2031647524 hasConceptScore W2031647524C15744967 @default.
- W2031647524 hasConceptScore W2031647524C169760540 @default.