FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031650377> ?p ?o ?g. }

• W2031650377 endingPage "1966" @default.
• W2031650377 startingPage "1957" @default.
• W2031650377 abstract "Immune responsive gene 1 (IRG1) is highly expressed in mammalian macrophages during inflammation. However, the role of IRG1 in tumorigenesis remains unclear. In the present study, we aimed to clarify the epigenetic regulation and biological functions of IRG1 in glioma. We found that the expression level of IRG1 influenced the WHO stage in 140 glioma patients. Overexpression of IRG1 increased the growth, invasion, and tumorigenesis in U251 and SHG-44 glioma cells both in vitro and in vivo. Suppression of IRG1 expression by si-IRG1 decreased the levels of cell cycle regulatory proteins, namely, E2F1, p21, CDK4, CDK6 and cyclin D1. Knockdown of IRG1 expression by RNA interference increased E-cadherin expression and decreased the amounts of snail and vimentin. Furthermore, the suppression of IRG1 expression inhibited the expression of NF-κB and STAT3, suggesting a role of IRG1 in regulating the genes associated with these factors and thereby contributing to a decrease in glioma cell proliferation, migration and invasion. Collectively, our findings revealed that IRG1 is a candidate oncogene that is amplified in glioma and is involved in novel mechanisms that influence glioma pathogenesis." @default.
• W2031650377 created "2016-06-24" @default.
• W2031650377 creator A5021298676 @default.
• W2031650377 creator A5025705903 @default.
• W2031650377 creator A5033886716 @default.
• W2031650377 creator A5035269751 @default.
• W2031650377 creator A5043768971 @default.
• W2031650377 creator A5057195962 @default.
• W2031650377 creator A5090924765 @default.
• W2031650377 date "2014-09-10" @default.
• W2031650377 modified "2023-10-16" @default.
• W2031650377 title "Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma" @default.
• W2031650377 cites W1483706589 @default.
• W2031650377 cites W1491756694 @default.
• W2031650377 cites W1531083859 @default.
• W2031650377 cites W1969854275 @default.
• W2031650377 cites W1975556592 @default.
• W2031650377 cites W1990053116 @default.
• W2031650377 cites W2011103030 @default.
• W2031650377 cites W2015343533 @default.
• W2031650377 cites W2019997079 @default.
• W2031650377 cites W2026480865 @default.
• W2031650377 cites W2026721588 @default.
• W2031650377 cites W2040576393 @default.
• W2031650377 cites W2044499368 @default.
• W2031650377 cites W2047624845 @default.
• W2031650377 cites W2054034728 @default.
• W2031650377 cites W2054174996 @default.
• W2031650377 cites W2093139840 @default.
• W2031650377 cites W2101380428 @default.
• W2031650377 cites W2142329928 @default.
• W2031650377 cites W2147590200 @default.
• W2031650377 cites W2150421279 @default.
• W2031650377 cites W2166300190 @default.
• W2031650377 cites W2168056656 @default.
• W2031650377 cites W2171932084 @default.
• W2031650377 cites W2334090685 @default.
• W2031650377 doi "https://doi.org/10.3892/or.2014.3474" @default.
• W2031650377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25216059" @default.
• W2031650377 hasPublicationYear "2014" @default.
• W2031650377 type Work @default.
• W2031650377 sameAs 2031650377 @default.
• W2031650377 citedByCount "29" @default.
• W2031650377 countsByYear W20316503772018 @default.
• W2031650377 countsByYear W20316503772019 @default.
• W2031650377 countsByYear W20316503772020 @default.
• W2031650377 countsByYear W20316503772021 @default.
• W2031650377 countsByYear W20316503772022 @default.
• W2031650377 countsByYear W20316503772023 @default.
• W2031650377 crossrefType "journal-article" @default.
• W2031650377 hasAuthorship W2031650377A5021298676 @default.
• W2031650377 hasAuthorship W2031650377A5025705903 @default.
• W2031650377 hasAuthorship W2031650377A5033886716 @default.
• W2031650377 hasAuthorship W2031650377A5035269751 @default.
• W2031650377 hasAuthorship W2031650377A5043768971 @default.
• W2031650377 hasAuthorship W2031650377A5057195962 @default.
• W2031650377 hasAuthorship W2031650377A5090924765 @default.
• W2031650377 hasBestOaLocation W20316503771 @default.
• W2031650377 hasConcept C104317684 @default.
• W2031650377 hasConcept C121608353 @default.
• W2031650377 hasConcept C173396325 @default.
• W2031650377 hasConcept C199649820 @default.
• W2031650377 hasConcept C199835354 @default.
• W2031650377 hasConcept C203014093 @default.
• W2031650377 hasConcept C2778227246 @default.
• W2031650377 hasConcept C2781018059 @default.
• W2031650377 hasConcept C29537977 @default.
• W2031650377 hasConcept C502942594 @default.
• W2031650377 hasConcept C54355233 @default.
• W2031650377 hasConcept C555283112 @default.
• W2031650377 hasConcept C86803240 @default.
• W2031650377 hasConcept C8891405 @default.
• W2031650377 hasConceptScore W2031650377C104317684 @default.
• W2031650377 hasConceptScore W2031650377C121608353 @default.
• W2031650377 hasConceptScore W2031650377C173396325 @default.
• W2031650377 hasConceptScore W2031650377C199649820 @default.
• W2031650377 hasConceptScore W2031650377C199835354 @default.
• W2031650377 hasConceptScore W2031650377C203014093 @default.
• W2031650377 hasConceptScore W2031650377C2778227246 @default.
• W2031650377 hasConceptScore W2031650377C2781018059 @default.
• W2031650377 hasConceptScore W2031650377C29537977 @default.
• W2031650377 hasConceptScore W2031650377C502942594 @default.
• W2031650377 hasConceptScore W2031650377C54355233 @default.
• W2031650377 hasConceptScore W2031650377C555283112 @default.
• W2031650377 hasConceptScore W2031650377C86803240 @default.
• W2031650377 hasConceptScore W2031650377C8891405 @default.
• W2031650377 hasIssue "5" @default.
• W2031650377 hasLocation W20316503771 @default.
• W2031650377 hasLocation W20316503772 @default.
• W2031650377 hasOpenAccess W2031650377 @default.
• W2031650377 hasPrimaryLocation W20316503771 @default.
• W2031650377 hasRelatedWork W2425930418 @default.
• W2031650377 hasRelatedWork W2530512275 @default.
• W2031650377 hasRelatedWork W2618376745 @default.
• W2031650377 hasRelatedWork W2791144544 @default.
• W2031650377 hasRelatedWork W2797352271 @default.
• W2031650377 hasRelatedWork W2805657231 @default.
• W2031650377 hasRelatedWork W2884184577 @default.

• next