Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031675248> ?p ?o ?g. }
- W2031675248 endingPage "844" @default.
- W2031675248 startingPage "835" @default.
- W2031675248 abstract "Abstract Objective The overall permeability of the blood‐brain barrier (BBB) is regulated by specialized cerebral endothelial cells and their junctional complexes, consisting of adherens junctions (AJs) and tight junctions (TJs). Among the members of the glucose transporters (Glut), Glut1 is a unique molecule expressed in the cerebral endothelial cells. Glut1 and the junctional proteins are concomitantly downregulated in situations in which breakdown of the BBB has taken place. We hypothesized that the expression of Glut1 may play a significant role in the development of the cerebral microvasculature with BBB properties. To date, there is no information on the role of Glut1 during the development of BBB. In the present study, the in vivo effects of Glut1 knockdown on the cerebral vascular development were investigated. Methods Zebrafish was used as a model organism. We confirmed that the structure of the zebrafish homologue of Glut1 is highly similar to the human Glut1 and that the function of the Glut1‐mediated cerebral uptake of glucose is evolutionally conserved. Results In the Glut1 knockdown model, we observed loss of the cerebral endothelial cells, with concomitant downregulation of the junctional proteins important for intactness of the AJs/TJs and impaired cerebral circulation. The resulting leaky BBB caused vasogenic brain edema. Interpretation The data suggest a crucial role of Glut1 in the development of the cerebral endothelial cells with BBB properties in vivo. The findings suggest that modulation of Glut1 expression and function may open new directions of research for therapeutic strategies to prevent vasogenic brain edema. Ann Neurol 2010;" @default.
- W2031675248 created "2016-06-24" @default.
- W2031675248 creator A5024269155 @default.
- W2031675248 creator A5063092847 @default.
- W2031675248 creator A5065398037 @default.
- W2031675248 creator A5065513365 @default.
- W2031675248 creator A5073755574 @default.
- W2031675248 creator A5075152654 @default.
- W2031675248 date "2010-12-01" @default.
- W2031675248 modified "2023-10-18" @default.
- W2031675248 title "Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo" @default.
- W2031675248 cites W1535419310 @default.
- W2031675248 cites W1797273806 @default.
- W2031675248 cites W1861095564 @default.
- W2031675248 cites W1964594757 @default.
- W2031675248 cites W1964673759 @default.
- W2031675248 cites W1970648988 @default.
- W2031675248 cites W1971118159 @default.
- W2031675248 cites W1973763077 @default.
- W2031675248 cites W1978999685 @default.
- W2031675248 cites W1986405547 @default.
- W2031675248 cites W1993607801 @default.
- W2031675248 cites W1996123970 @default.
- W2031675248 cites W1998713702 @default.
- W2031675248 cites W2012919091 @default.
- W2031675248 cites W2017839807 @default.
- W2031675248 cites W2024621623 @default.
- W2031675248 cites W2032112615 @default.
- W2031675248 cites W2032382800 @default.
- W2031675248 cites W2040480145 @default.
- W2031675248 cites W2042896859 @default.
- W2031675248 cites W2045247798 @default.
- W2031675248 cites W2045268088 @default.
- W2031675248 cites W2045651327 @default.
- W2031675248 cites W2045971338 @default.
- W2031675248 cites W2055452454 @default.
- W2031675248 cites W2055823814 @default.
- W2031675248 cites W2076015301 @default.
- W2031675248 cites W2085179410 @default.
- W2031675248 cites W2091760375 @default.
- W2031675248 cites W2091805482 @default.
- W2031675248 cites W2097922085 @default.
- W2031675248 cites W2103724228 @default.
- W2031675248 cites W2104567497 @default.
- W2031675248 cites W2107080306 @default.
- W2031675248 cites W2107960986 @default.
- W2031675248 cites W2110053523 @default.
- W2031675248 cites W2111982133 @default.
- W2031675248 cites W2122341732 @default.
- W2031675248 cites W2126255509 @default.
- W2031675248 cites W2128687105 @default.
- W2031675248 cites W2135368782 @default.
- W2031675248 cites W2147176626 @default.
- W2031675248 cites W2148992136 @default.
- W2031675248 cites W2155385977 @default.
- W2031675248 cites W2170676509 @default.
- W2031675248 cites W2171688913 @default.
- W2031675248 cites W4255432858 @default.
- W2031675248 doi "https://doi.org/10.1002/ana.22318" @default.
- W2031675248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21194153" @default.
- W2031675248 hasPublicationYear "2010" @default.
- W2031675248 type Work @default.
- W2031675248 sameAs 2031675248 @default.
- W2031675248 citedByCount "81" @default.
- W2031675248 countsByYear W20316752482012 @default.
- W2031675248 countsByYear W20316752482013 @default.
- W2031675248 countsByYear W20316752482014 @default.
- W2031675248 countsByYear W20316752482015 @default.
- W2031675248 countsByYear W20316752482016 @default.
- W2031675248 countsByYear W20316752482017 @default.
- W2031675248 countsByYear W20316752482018 @default.
- W2031675248 countsByYear W20316752482019 @default.
- W2031675248 countsByYear W20316752482020 @default.
- W2031675248 countsByYear W20316752482021 @default.
- W2031675248 countsByYear W20316752482022 @default.
- W2031675248 countsByYear W20316752482023 @default.
- W2031675248 crossrefType "journal-article" @default.
- W2031675248 hasAuthorship W2031675248A5024269155 @default.
- W2031675248 hasAuthorship W2031675248A5063092847 @default.
- W2031675248 hasAuthorship W2031675248A5065398037 @default.
- W2031675248 hasAuthorship W2031675248A5065513365 @default.
- W2031675248 hasAuthorship W2031675248A5073755574 @default.
- W2031675248 hasAuthorship W2031675248A5075152654 @default.
- W2031675248 hasConcept C104317684 @default.
- W2031675248 hasConcept C127561419 @default.
- W2031675248 hasConcept C134018914 @default.
- W2031675248 hasConcept C1491633281 @default.
- W2031675248 hasConcept C149402561 @default.
- W2031675248 hasConcept C161573976 @default.
- W2031675248 hasConcept C169760540 @default.
- W2031675248 hasConcept C173396325 @default.
- W2031675248 hasConcept C177779419 @default.
- W2031675248 hasConcept C185592680 @default.
- W2031675248 hasConcept C201508349 @default.
- W2031675248 hasConcept C207001950 @default.
- W2031675248 hasConcept C2776878037 @default.
- W2031675248 hasConcept C2777952866 @default.
- W2031675248 hasConcept C2778402981 @default.