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- W2031695150 abstract "The most significant study pertaining to the management of demyelinating optic neuritis is the Optic Neuritis Treatment Trial. For the first time, ample data from a well-done study is presented to guide the clinician in the decision to offer intravenous methylprednisolone, oral prednisone, or observation alone. The evidence supports the abandonment of prednisone therapy for typical demyelinating optic neuritis. Methylprednisolone therapy accelerates visual recovery when visual acuity is 20/40 or worse and lessens loss of vision at 6 months in those patients who present with 20/200 vision or worse. This study also indicates that commonly used laboratory evaluations of demyelinating optic neuritis may be deferred. Many pedigrees of Leber's hereditary optic neuropathy have presented without the usual positive family history or typical fundus findings. Biotinidase deficiency has been identified as a treatable form of hereditary optic atrophy that is accompanied by spastic paresis." @default.
- W2031695150 created "2016-06-24" @default.
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- W2031695150 date "1992-10-01" @default.
- W2031695150 modified "2023-10-16" @default.
- W2031695150 title "Demyelinating and degenerative conditions affecting the visual pathways" @default.
- W2031695150 doi "https://doi.org/10.1097/00055735-199210000-00004" @default.
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