Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031716445> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2031716445 abstract "Cytoplasmic-mitochondria-enriched and synaptosome-enriched subcellular fractions were prepared from rat brain to study certain kinetic properties of γ-aminobutyrate:α-oxoglutarate aminotransferase (GABA-T) (EC 2.6.1.19) from each of the sources. From this study two differences emerged. Firstly, the cytoplasmic enzyme exhibited an eightfold greater affinity for γ-aminobutyric acid (GABA) than did the synaptosomal GABA-T; the K m being 6.5 mM and 53 mM, respectively. Secondly, synaptosomal GABA-T is comparatively more susceptible to inhibition by the substrate analogues 2,4-diaminobutyric acid (DABA) and aminooxyacetic acid (AOAA) than is the enzyme from the cytoplasmic mitochondrial fraction. In each case the inhibition was of a competitive nature with respect to GABA. The K i for the DABA was 13 mM for the cytoplasmic-derived enzyme and 8 mM for the synaptosomal enzyme. With AOAA the K i was 0.1 μM and 0.06 μM for the synaptosomal and cytoplasmic mitochondrial enzyme, respectively. These results provide further evidence that GABA-T from cytoplasmic mitochondria is different in several respects from the enzyme found in synaptosomes." @default.
- W2031716445 created "2016-06-24" @default.
- W2031716445 creator A5035399709 @default.
- W2031716445 creator A5038498765 @default.
- W2031716445 creator A5044281081 @default.
- W2031716445 creator A5068926777 @default.
- W2031716445 date "1977-04-01" @default.
- W2031716445 modified "2023-09-26" @default.
- W2031716445 title "The inhibition by substrate analogues of γ-aminobutyrate aminotransferase from mitochondria of different subcellular fractions of rat brain" @default.
- W2031716445 doi "https://doi.org/10.1139/o77-067" @default.
- W2031716445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/870153" @default.
- W2031716445 hasPublicationYear "1977" @default.
- W2031716445 type Work @default.
- W2031716445 sameAs 2031716445 @default.
- W2031716445 citedByCount "20" @default.
- W2031716445 countsByYear W20317164452017 @default.
- W2031716445 countsByYear W20317164452022 @default.
- W2031716445 crossrefType "journal-article" @default.
- W2031716445 hasAuthorship W2031716445A5035399709 @default.
- W2031716445 hasAuthorship W2031716445A5038498765 @default.
- W2031716445 hasAuthorship W2031716445A5044281081 @default.
- W2031716445 hasAuthorship W2031716445A5068926777 @default.
- W2031716445 hasConcept C181199279 @default.
- W2031716445 hasConcept C185592680 @default.
- W2031716445 hasConcept C18903297 @default.
- W2031716445 hasConcept C190062978 @default.
- W2031716445 hasConcept C202751555 @default.
- W2031716445 hasConcept C2776627618 @default.
- W2031716445 hasConcept C2777289219 @default.
- W2031716445 hasConcept C2778921374 @default.
- W2031716445 hasConcept C28859421 @default.
- W2031716445 hasConcept C55493867 @default.
- W2031716445 hasConcept C86803240 @default.
- W2031716445 hasConceptScore W2031716445C181199279 @default.
- W2031716445 hasConceptScore W2031716445C185592680 @default.
- W2031716445 hasConceptScore W2031716445C18903297 @default.
- W2031716445 hasConceptScore W2031716445C190062978 @default.
- W2031716445 hasConceptScore W2031716445C202751555 @default.
- W2031716445 hasConceptScore W2031716445C2776627618 @default.
- W2031716445 hasConceptScore W2031716445C2777289219 @default.
- W2031716445 hasConceptScore W2031716445C2778921374 @default.
- W2031716445 hasConceptScore W2031716445C28859421 @default.
- W2031716445 hasConceptScore W2031716445C55493867 @default.
- W2031716445 hasConceptScore W2031716445C86803240 @default.
- W2031716445 hasLocation W20317164451 @default.
- W2031716445 hasLocation W20317164452 @default.
- W2031716445 hasOpenAccess W2031716445 @default.
- W2031716445 hasPrimaryLocation W20317164451 @default.
- W2031716445 hasRelatedWork W141429482 @default.
- W2031716445 hasRelatedWork W1996495692 @default.
- W2031716445 hasRelatedWork W2008622680 @default.
- W2031716445 hasRelatedWork W2056237943 @default.
- W2031716445 hasRelatedWork W2058619471 @default.
- W2031716445 hasRelatedWork W2065661603 @default.
- W2031716445 hasRelatedWork W2073934313 @default.
- W2031716445 hasRelatedWork W2106070853 @default.
- W2031716445 hasRelatedWork W2147455688 @default.
- W2031716445 hasRelatedWork W2614204364 @default.
- W2031716445 isParatext "false" @default.
- W2031716445 isRetracted "false" @default.
- W2031716445 magId "2031716445" @default.
- W2031716445 workType "article" @default.