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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031726467> ?p ?o ?g. }

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• W2031726467 abstract "A series of hitherto unknown 3′-α-[1,2,3]-substituted triazolo-2′,3′-dideoxypyrimidine nucleoside analogues of the anti-HIV 3′-azido-3′-deoxythymidine (AZT) were synthesized through catalyzed alkyne-azide 1,3-dipolar cycloaddition (Huisgen reaction). Those 3′-[1,2,3]-triazolo analogues bearing an azido alkyl chain were evaluated for their anti-HIV activity against HIV-1 in primary human lymphocytes as well as for their cytotoxicity in different cells. None of them inhibit HIV replication (EC50 > 20 μM); two of them were converted to their triphosphate form to evaluate their HIV-RT inhibition." @default.
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• W2031726467 date "2011-04-01" @default.
• W2031726467 modified "2023-09-23" @default.
• W2031726467 title "Synthesis and Anti-HIV Evaluation of 3′-Triazolo Nucleosides" @default.
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• W2031726467 doi "https://doi.org/10.1080/15257770.2011.580291" @default.
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