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- W2031729360 abstract "A deficiency of brain 5-HT may be implicated in the mechanism of central pain, as thalamic pain, phantom limb and some essential headaches: according to this new theory the decline of 5-HT may induce a condition of supersensitivity and/or may render the brain chemical barrier permeable to pain when the monoamine is considered as an inhibiting mediator. In some migraine patients treated with reserpine and, in a major extent, with fenclonine, a reversible syndrome similar to that of the central pain appeared: vascular supersensitivity to noradrenaline and 5-HT with reserpine, and to 5-HT alone with fenclonine, was also clearly detectable. The pain syndrome following fenclonine was reversible and repeatable when the drug was discontinued and readministered, respectively. Patients suffering from headache appeared particularly susceptible to the pain-producing action of fenclonine, thus supporting the hypothesis of a defect in 5-HT turnover in the pathogenesis of migraine." @default.
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- W2031729360 date "1971-12-01" @default.
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- W2031729360 title "Pain syndrome in man following treatment with p-chlorophenylalanine" @default.
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- W2031729360 doi "https://doi.org/10.1016/0031-6989(71)90012-9" @default.
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