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- W2031736092 abstract "Biofilms are highly structured microbial communities that are enmeshed in a self-produced extracellular matrix. Within the complex oral microbiome, Streptococcus mutans is a major producer of extracellular polymeric substances including exopolysaccharides (EPS), eDNA and lipoteichoic acid (LTA). EPS produced by S. mutans-derived exoenzymes promote local accumulation of microbes on the teeth, while forming a spatially heterogeneous and diffusion-limiting matrix that protects embedded bacteria. The EPS-rich matrix provides mechanical stability/cohesiveness and facilitates the creation of highly acidic microenvironments, which are critical for the pathogenesis of dental caries. In parallel, S. mutans also releases eDNA and LTA, which can contribute with matrix development. eDNA enhances EPS (glucan) synthesis locally, increasing the adhesion of S. mutans to saliva-coated apatitic surfaces and the assembly of highly cohesive biofilms. eDNA and other extracellular substances, acting in concert with EPS, may impact the functional properties of the matrix and the virulence of cariogenic biofilms. Enhanced understanding about the assembly principles of the matrix may lead to efficacious approaches to control biofilm-related diseases." @default.
- W2031736092 created "2016-06-24" @default.
- W2031736092 creator A5021958795 @default.
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- W2031736092 date "2015-02-13" @default.
- W2031736092 modified "2023-10-10" @default.
- W2031736092 title "Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms" @default.
- W2031736092 cites W1033702852 @default.
- W2031736092 cites W1741226872 @default.
- W2031736092 cites W1753159784 @default.
- W2031736092 cites W1799869599 @default.
- W2031736092 cites W1826109625 @default.
- W2031736092 cites W1883937874 @default.
- W2031736092 cites W1908888112 @default.
- W2031736092 cites W1913010905 @default.
- W2031736092 cites W1916574382 @default.
- W2031736092 cites W1936611879 @default.
- W2031736092 cites W1968699842 @default.
- W2031736092 cites W1969681100 @default.
- W2031736092 cites W1973681473 @default.
- W2031736092 cites W1975387135 @default.
- W2031736092 cites W1980739800 @default.
- W2031736092 cites W1990524600 @default.
- W2031736092 cites W1990872364 @default.
- W2031736092 cites W1993682711 @default.
- W2031736092 cites W1996064131 @default.
- W2031736092 cites W1998303827 @default.
- W2031736092 cites W2001070837 @default.
- W2031736092 cites W2006108371 @default.
- W2031736092 cites W2008123405 @default.
- W2031736092 cites W2010227932 @default.
- W2031736092 cites W2024060557 @default.
- W2031736092 cites W2025003389 @default.
- W2031736092 cites W2026276153 @default.
- W2031736092 cites W2026396167 @default.
- W2031736092 cites W2033363653 @default.
- W2031736092 cites W2037918377 @default.
- W2031736092 cites W2044550254 @default.
- W2031736092 cites W2049104619 @default.
- W2031736092 cites W2053460725 @default.
- W2031736092 cites W2053830048 @default.
- W2031736092 cites W2053858964 @default.
- W2031736092 cites W2053959757 @default.
- W2031736092 cites W2058975831 @default.
- W2031736092 cites W2064066831 @default.
- W2031736092 cites W2064774772 @default.
- W2031736092 cites W2065259488 @default.
- W2031736092 cites W2067508903 @default.
- W2031736092 cites W2070300719 @default.
- W2031736092 cites W2070804748 @default.
- W2031736092 cites W2074565886 @default.
- W2031736092 cites W2075049932 @default.
- W2031736092 cites W2079906948 @default.
- W2031736092 cites W2081016978 @default.
- W2031736092 cites W2090392945 @default.
- W2031736092 cites W2095415260 @default.
- W2031736092 cites W2097309930 @default.
- W2031736092 cites W2098586707 @default.
- W2031736092 cites W2098976315 @default.
- W2031736092 cites W2099103625 @default.
- W2031736092 cites W2102252790 @default.
- W2031736092 cites W2104246257 @default.
- W2031736092 cites W2105659079 @default.
- W2031736092 cites W2108367771 @default.
- W2031736092 cites W2112421184 @default.
- W2031736092 cites W2120978086 @default.
- W2031736092 cites W2122836009 @default.
- W2031736092 cites W2124534024 @default.
- W2031736092 cites W2128618257 @default.
- W2031736092 cites W2129622024 @default.
- W2031736092 cites W2129723345 @default.
- W2031736092 cites W2130534359 @default.
- W2031736092 cites W2133838892 @default.
- W2031736092 cites W2138143534 @default.
- W2031736092 cites W2141824074 @default.
- W2031736092 cites W2141894926 @default.
- W2031736092 cites W2142179819 @default.
- W2031736092 cites W2143640539 @default.
- W2031736092 cites W2148337956 @default.
- W2031736092 cites W2152470968 @default.
- W2031736092 cites W2155050787 @default.
- W2031736092 cites W2155596771 @default.
- W2031736092 cites W2157806471 @default.
- W2031736092 cites W2164479375 @default.
- W2031736092 cites W2166083475 @default.
- W2031736092 cites W2169464317 @default.
- W2031736092 cites W2169503816 @default.
- W2031736092 cites W2171048246 @default.
- W2031736092 cites W2224853244 @default.
- W2031736092 cites W2335552895 @default.
- W2031736092 cites W2397918225 @default.
- W2031736092 cites W2498223496 @default.
- W2031736092 cites W4231311323 @default.
- W2031736092 cites W4246167651 @default.
- W2031736092 cites W4249723987 @default.
- W2031736092 doi "https://doi.org/10.3389/fcimb.2015.00010" @default.
- W2031736092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4327733" @default.