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- W2031765362 abstract "<h2>ABSTRACT</h2><h3>Objective</h3> This study examines the association of fitness on glycemic variability (GV) in adolescents with type 1 diabetes mellitus (T1DM). GV has been associated with high frequency of hyper-and hypoglycemia. <h3>Methods</h3> Nineteen adolescents with T1DM, ages 14 to 19 years, underwent aerobic fitness testing to determine their maximal aerobic capacity (VO<sub>2</sub> max). A continuous glucose monitoring (CGM) device was placed on each subject and worn for 3 to 5 days until a return visit when the subjects underwent a 1-hour treadmill exercise session. Mean amplitude of glycemic excursion (MAGE) was calculated from the CGM data collected between the 2 study visits. Metabolic equivalent (MET), a measure of accumulated metabolic workload during the exercise session, was also calculated. <h3>Results</h3> Mean VO<sub>2</sub> max was 46.6 ± 6.8 mL/kg/min, with a range of 34.8 to 57.0 mL/kg/min. Mean MET during the exercise session was 577.2 ± 102.4 and ranged from 354.3 to 716.2 METs. There was an inverse association between VO<sub>2</sub> max and MAGE (<i>r</i> = −0.46; 95% confidence interval [CI], −0.01 to −0.76; <i>P</i> = .048). MET load and MAGE also had an inverse relationship (<i>r</i> = −0.48; 95% CI, −0.03 to −0.77; <i>P</i> = .037). <h3>Conclusion</h3> GV is inversely associated with fitness and MET load. Aerobic fitness should be promoted in adolescents with T1DM not only because of its multiple beneficial effects but also due to a possible association with GV, leading to fewer extremes in hypo-and hyperglycemia. <b>(Endocr Pract. 2014;20:566-570)</b>" @default.
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- W2031765362 date "2014-06-01" @default.
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- W2031765362 title "Aerobic Fitness and Glycemic Variability in Adolescents with Type 1 Diabetes" @default.
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