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- W2031773757 abstract "Background: Suboptimal adherence to investigational products has been associated with ineffectual outcomes in clinical trials. This review provides a summary of factors that influenced adherence in HIV prevention trials. Method: Our search included user-dependent trials that focused on sexual transmission of HIV. MEDLINE, Cochrane CENTRAL, Web of Knowledge v5.6, and Clinicaltrials.gov databases were searched as of August, 2012 and HIV/AIDS conference abstracts, March 2013. Results: Twenty four HIV prevention trials were included. Main barriers related to adherence included; pregnancies, mobility and relocation from study area, adherence declining overtime as a result of fatigue, stigma and negative rumors about the clinical trials, and gel volume to be inserted perceived as too much. Other reported barriers were side effects, alcohol use, running out of study product after missing clinic visits, pill/gel sharing, forgetting to take/use study product, unplanned sex (in studies with coitaldependent dosing), concealing trial participation from partner, difficulty in sustaining high adherence levels in study products with a short half-life of 1-3 hours, and simultaneous use of multiple products. Key facilitators of adherence included; male involvement in trial" @default.
- W2031773757 created "2016-06-24" @default.
- W2031773757 creator A5065417009 @default.
- W2031773757 date "2013-01-10" @default.
- W2031773757 modified "2023-09-27" @default.
- W2031773757 title "Barriers and Facilitators of Adherence in User-Dependent HIV Prevention Trials, a Systematic Review" @default.
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- W2031773757 doi "https://doi.org/10.9734/isrr/2013/3531" @default.
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