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- W2031793812 abstract "In areas such as oncology, two-stage designs are often preferred as compared to one-stage designs due to the ability to stop the trial early when faced with evidence of lack of sufficient efficacy and the associated sample size savings. We present exact two-stage designs based on Barnard's exact test for differences in proportions and compare the designs to those proposed by Kepner ( 2010 ) and Jung ( 2010 ). In addition, we present tables of decision rules under a variety of assumed realities for use in trial planning. The procedure is recommended for use due to the substantial sample size savings experienced." @default.
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- W2031793812 date "2013-08-19" @default.
- W2031793812 modified "2023-09-25" @default.
- W2031793812 title "Randomized Two-Stage Phase II Clinical Trial Designs Based on Barnard's Exact Test" @default.
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- W2031793812 doi "https://doi.org/10.1080/10543406.2013.813525" @default.
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