FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031799130> ?p ?o ?g. }

• W2031799130 endingPage "38" @default.
• W2031799130 startingPage "33" @default.
• W2031799130 abstract "IL-12p40 is known as a component of the bioactive cytokines interleukin (IL)-12 and IL-23 but it is not widely recognized as having intrinsic functional activity. Recent publications have altered this perception and support an independent role for IL-12p40. IL-12p40 is induced in excess over the other subunits of IL-12 and IL-23 and can exist in a monomeric or homodimeric form. Its most widely appreciated function is to provide a negative feedback loop by competitively binding to the IL-12 receptor. However, IL-12p40 acts as a chemoattractant for macrophages and promotes the migration of bacterially stimulated dendritic cells. It is associated with several pathogenic inflammatory responses such as silicosis, graft rejection and asthma but it is also protective in a mycobacterial model. An appreciation of the independent function of IL-12p40 is important for improving our understanding of both protective and pathogenic immune responses. IL-12p40 is known as a component of the bioactive cytokines interleukin (IL)-12 and IL-23 but it is not widely recognized as having intrinsic functional activity. Recent publications have altered this perception and support an independent role for IL-12p40. IL-12p40 is induced in excess over the other subunits of IL-12 and IL-23 and can exist in a monomeric or homodimeric form. Its most widely appreciated function is to provide a negative feedback loop by competitively binding to the IL-12 receptor. However, IL-12p40 acts as a chemoattractant for macrophages and promotes the migration of bacterially stimulated dendritic cells. It is associated with several pathogenic inflammatory responses such as silicosis, graft rejection and asthma but it is also protective in a mycobacterial model. An appreciation of the independent function of IL-12p40 is important for improving our understanding of both protective and pathogenic immune responses." @default.
• W2031799130 created "2016-06-24" @default.
• W2031799130 creator A5040981514 @default.
• W2031799130 creator A5083188118 @default.
• W2031799130 date "2007-01-01" @default.
• W2031799130 modified "2023-10-11" @default.
• W2031799130 title "IL-12p40: an inherently agonistic cytokine" @default.
• W2031799130 cites W1486973386 @default.
• W2031799130 cites W1488708265 @default.
• W2031799130 cites W1509377507 @default.
• W2031799130 cites W1524541469 @default.
• W2031799130 cites W1537495156 @default.
• W2031799130 cites W1555115634 @default.
• W2031799130 cites W1556169045 @default.
• W2031799130 cites W1562632940 @default.
• W2031799130 cites W1585461212 @default.
• W2031799130 cites W1586837651 @default.
• W2031799130 cites W1592262265 @default.
• W2031799130 cites W1597098734 @default.
• W2031799130 cites W1678871737 @default.
• W2031799130 cites W1718964427 @default.
• W2031799130 cites W1763296980 @default.
• W2031799130 cites W1765079284 @default.
• W2031799130 cites W1838853754 @default.
• W2031799130 cites W1879781226 @default.
• W2031799130 cites W1945946018 @default.
• W2031799130 cites W1949462869 @default.
• W2031799130 cites W1961932285 @default.
• W2031799130 cites W1965471441 @default.
• W2031799130 cites W1968918322 @default.
• W2031799130 cites W1970160145 @default.
• W2031799130 cites W1974831380 @default.
• W2031799130 cites W1977817262 @default.
• W2031799130 cites W1978971257 @default.
• W2031799130 cites W1981148628 @default.
• W2031799130 cites W1987641831 @default.
• W2031799130 cites W1988851152 @default.
• W2031799130 cites W1989520579 @default.
• W2031799130 cites W1991587280 @default.
• W2031799130 cites W1998204285 @default.
• W2031799130 cites W2009101924 @default.
• W2031799130 cites W2009219530 @default.
• W2031799130 cites W2014938597 @default.
• W2031799130 cites W2015479125 @default.
• W2031799130 cites W2016895379 @default.
• W2031799130 cites W2017684091 @default.
• W2031799130 cites W2018750367 @default.
• W2031799130 cites W2023650245 @default.
• W2031799130 cites W2025202023 @default.
• W2031799130 cites W2035027025 @default.
• W2031799130 cites W2036587315 @default.
• W2031799130 cites W2042960115 @default.
• W2031799130 cites W2044325609 @default.
• W2031799130 cites W2055618586 @default.
• W2031799130 cites W2062922499 @default.
• W2031799130 cites W2063053561 @default.
• W2031799130 cites W2087905758 @default.
• W2031799130 cites W2091095985 @default.
• W2031799130 cites W2098907119 @default.
• W2031799130 cites W2101784086 @default.
• W2031799130 cites W2104439753 @default.
• W2031799130 cites W2107231521 @default.
• W2031799130 cites W2126639608 @default.
• W2031799130 cites W2131727319 @default.
• W2031799130 cites W2132508910 @default.
• W2031799130 cites W2133435354 @default.
• W2031799130 cites W2149763456 @default.
• W2031799130 cites W2156339112 @default.
• W2031799130 cites W2163905998 @default.
• W2031799130 doi "https://doi.org/10.1016/j.it.2006.11.002" @default.
• W2031799130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17126601" @default.
• W2031799130 hasPublicationYear "2007" @default.
• W2031799130 type Work @default.
• W2031799130 sameAs 2031799130 @default.
• W2031799130 citedByCount "268" @default.
• W2031799130 countsByYear W20317991302012 @default.
• W2031799130 countsByYear W20317991302013 @default.
• W2031799130 countsByYear W20317991302014 @default.
• W2031799130 countsByYear W20317991302015 @default.
• W2031799130 countsByYear W20317991302016 @default.
• W2031799130 countsByYear W20317991302017 @default.
• W2031799130 countsByYear W20317991302018 @default.
• W2031799130 countsByYear W20317991302019 @default.
• W2031799130 countsByYear W20317991302020 @default.
• W2031799130 countsByYear W20317991302021 @default.
• W2031799130 countsByYear W20317991302022 @default.
• W2031799130 countsByYear W20317991302023 @default.
• W2031799130 crossrefType "journal-article" @default.
• W2031799130 hasAuthorship W2031799130A5040981514 @default.
• W2031799130 hasAuthorship W2031799130A5083188118 @default.
• W2031799130 hasConcept C14036430 @default.
• W2031799130 hasConcept C170493617 @default.
• W2031799130 hasConcept C187316574 @default.
• W2031799130 hasConcept C203014093 @default.
• W2031799130 hasConcept C2778690821 @default.
• W2031799130 hasConcept C54166955 @default.
• W2031799130 hasConcept C54355233 @default.
• W2031799130 hasConcept C86803240 @default.

• next