FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031808440> ?p ?o ?g. }

• W2031808440 endingPage "1439" @default.
• W2031808440 startingPage "1430" @default.
• W2031808440 abstract "Abstract Dendritic cells (DC) comprise a unique leukocyte population which controls primary immune responses. Recent studies indicate that DC express osteoprotegerin (OPG), a secreted tumor necrosis factor receptor homolog, which regulates DC survival, monocyte chemotaxis, and B cell development and function by ligating TNF family member receptor activator of NF‐κB ligand (RANKL). The precise regulators of OPG expression in DC have not been investigated. In this study, we assessed OPG mRNA steady state levels by Northern blot analysis and OPG protein secretion by an immunoassay in monocyte‐derived DC of different maturation, and the effect of different cytokines and hormones on OPG expression. OPG was upregulated with maturation of DC, whereas pretreatment of DC with 1α,25(OH) 2 vitamin D 3 , tamoxifen, or dexamethasone, agents that inhibit differentiation of DC, decreased OPG expression. In vivo, OPG was found to be colocalized with mature CD83 + DC in human tonsils by immunofluorescence confocal microscopy analysis. Furthermore, OPG was upregulated by TNF superfamily members TNF‐α, anti‐CD40, and RANKL, and by ligands of the Toll‐like/IL‐1 receptor family including IL‐1β, double‐stranded RNA (poly I:C), or lipopolysaccharide (LPS), all of which induce maturation of DC. Gene silencing by small interfering RNA (siRNA) directed against transcription factor NF‐κB abrogated the expression of OPG as demonstrated by real‐time PCR. In summary, we describe that the expression of OPG by DC increases with maturation and is NF‐κB‐dependent, possibly regulating immune responses in lymphoid tissues. J. Cell. Biochem. 100: 1430–1439, 2007. © 2006 Wiley‐Liss, Inc." @default.
• W2031808440 created "2016-06-24" @default.
• W2031808440 creator A5002343561 @default.
• W2031808440 creator A5004147537 @default.
• W2031808440 creator A5008038627 @default.
• W2031808440 creator A5017637135 @default.
• W2031808440 creator A5030915321 @default.
• W2031808440 creator A5065587334 @default.
• W2031808440 creator A5081378662 @default.
• W2031808440 date "2006-12-14" @default.
• W2031808440 modified "2023-10-12" @default.
• W2031808440 title "Osteoprotegerin expression in dendritic cells increases with maturation and is NF‐κB‐dependent" @default.
• W2031808440 cites W115611381 @default.
• W2031808440 cites W1502937057 @default.
• W2031808440 cites W1510237891 @default.
• W2031808440 cites W1534645474 @default.
• W2031808440 cites W1535236030 @default.
• W2031808440 cites W1545561369 @default.
• W2031808440 cites W1661544713 @default.
• W2031808440 cites W1713856372 @default.
• W2031808440 cites W1937290251 @default.
• W2031808440 cites W1978700475 @default.
• W2031808440 cites W1991091142 @default.
• W2031808440 cites W1995579100 @default.
• W2031808440 cites W2000647744 @default.
• W2031808440 cites W2007751085 @default.
• W2031808440 cites W2019663991 @default.
• W2031808440 cites W2044767152 @default.
• W2031808440 cites W2058026156 @default.
• W2031808440 cites W2061026306 @default.
• W2031808440 cites W2094374305 @default.
• W2031808440 cites W2106766464 @default.
• W2031808440 cites W2108244474 @default.
• W2031808440 cites W2111220263 @default.
• W2031808440 cites W2111759218 @default.
• W2031808440 cites W2123327611 @default.
• W2031808440 cites W2128843508 @default.
• W2031808440 cites W2129651548 @default.
• W2031808440 cites W2129937169 @default.
• W2031808440 cites W2134254929 @default.
• W2031808440 cites W2139620037 @default.
• W2031808440 cites W2141575322 @default.
• W2031808440 cites W2158299560 @default.
• W2031808440 cites W2161354474 @default.
• W2031808440 cites W2164822093 @default.
• W2031808440 cites W2166781825 @default.
• W2031808440 doi "https://doi.org/10.1002/jcb.21129" @default.
• W2031808440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17171649" @default.
• W2031808440 hasPublicationYear "2006" @default.
• W2031808440 type Work @default.
• W2031808440 sameAs 2031808440 @default.
• W2031808440 citedByCount "38" @default.
• W2031808440 countsByYear W20318084402012 @default.
• W2031808440 countsByYear W20318084402013 @default.
• W2031808440 countsByYear W20318084402014 @default.
• W2031808440 countsByYear W20318084402015 @default.
• W2031808440 countsByYear W20318084402016 @default.
• W2031808440 countsByYear W20318084402018 @default.
• W2031808440 countsByYear W20318084402019 @default.
• W2031808440 countsByYear W20318084402020 @default.
• W2031808440 countsByYear W20318084402021 @default.
• W2031808440 countsByYear W20318084402022 @default.
• W2031808440 countsByYear W20318084402023 @default.
• W2031808440 crossrefType "journal-article" @default.
• W2031808440 hasAuthorship W2031808440A5002343561 @default.
• W2031808440 hasAuthorship W2031808440A5004147537 @default.
• W2031808440 hasAuthorship W2031808440A5008038627 @default.
• W2031808440 hasAuthorship W2031808440A5017637135 @default.
• W2031808440 hasAuthorship W2031808440A5030915321 @default.
• W2031808440 hasAuthorship W2031808440A5065587334 @default.
• W2031808440 hasAuthorship W2031808440A5081378662 @default.
• W2031808440 hasConcept C104317684 @default.
• W2031808440 hasConcept C127561419 @default.
• W2031808440 hasConcept C13373296 @default.
• W2031808440 hasConcept C134018914 @default.
• W2031808440 hasConcept C153911025 @default.
• W2031808440 hasConcept C170493617 @default.
• W2031808440 hasConcept C17991360 @default.
• W2031808440 hasConcept C185592680 @default.
• W2031808440 hasConcept C203014093 @default.
• W2031808440 hasConcept C22615655 @default.
• W2031808440 hasConcept C2779428903 @default.
• W2031808440 hasConcept C2780426850 @default.
• W2031808440 hasConcept C2781184567 @default.
• W2031808440 hasConcept C54009773 @default.
• W2031808440 hasConcept C54355233 @default.
• W2031808440 hasConcept C55493867 @default.
• W2031808440 hasConcept C81885089 @default.
• W2031808440 hasConcept C86803240 @default.
• W2031808440 hasConcept C88045685 @default.
• W2031808440 hasConcept C8891405 @default.
• W2031808440 hasConcept C95444343 @default.
• W2031808440 hasConceptScore W2031808440C104317684 @default.
• W2031808440 hasConceptScore W2031808440C127561419 @default.
• W2031808440 hasConceptScore W2031808440C13373296 @default.
• W2031808440 hasConceptScore W2031808440C134018914 @default.
• W2031808440 hasConceptScore W2031808440C153911025 @default.
• W2031808440 hasConceptScore W2031808440C170493617 @default.

• next