FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031808809> ?p ?o ?g. }

• W2031808809 endingPage "69" @default.
• W2031808809 startingPage "62" @default.
• W2031808809 abstract "Mucosal administration of experimental autoimmune encephalomyelitis (EAE)-specific autoantigens can reduce the onset of disease. To examine whether cholera toxin-B-subunit (CTB)-conjugated EAE-specific T-cell epitope can reduce development of the autoimmune disease in mice, we produced a recombinant hybrid molecule of CTB fusion protein linked with proteolipid-protein (PLP)-peptide139-151(C140S) at levels up to 0.1 gram per liter culture media in Bacillus brevis as a secretion-expression system. Amino acid sequencing and GM1-receptor binding assay showed that this expression system produced a uniformed recombinant hybrid protein. EAE was induced in SJL/J mice by systemic administration with the PLP-peptide. When nasally immunized 5 times with 70 microg rCTB PLP-peptide hybrid protein, mice showed a significantly suppressed development of ongoing EAE and an inhibition of both the PLP-peptide-specific delayed-type hypersensitivity (DTH) responses and leukocyte infiltration into the spinal cord. In contrast, all mice given the PLP-peptide alone or the PLP-peptide with the free form of CTB did not suppress the development of EAE and DTH responses. These results suggest that nasal treatment with the recombinant B. brevis-derived hybrid protein of CTB and autoantigen peptide could prove useful in the control of multiple sclerosis." @default.
• W2031808809 created "2016-06-24" @default.
• W2031808809 creator A5028490934 @default.
• W2031808809 creator A5041704850 @default.
• W2031808809 creator A5058645779 @default.
• W2031808809 creator A5066064308 @default.
• W2031808809 creator A5077851223 @default.
• W2031808809 creator A5078873559 @default.
• W2031808809 creator A5084452013 @default.
• W2031808809 creator A5087178931 @default.
• W2031808809 creator A5088081540 @default.
• W2031808809 date "2001-01-01" @default.
• W2031808809 modified "2023-09-30" @default.
• W2031808809 title "Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis" @default.
• W2031808809 cites W1503958501 @default.
• W2031808809 cites W1964262147 @default.
• W2031808809 cites W1971449558 @default.
• W2031808809 cites W1974972571 @default.
• W2031808809 cites W1985077925 @default.
• W2031808809 cites W1988317772 @default.
• W2031808809 cites W1992686283 @default.
• W2031808809 cites W1993933931 @default.
• W2031808809 cites W1996416396 @default.
• W2031808809 cites W2020317622 @default.
• W2031808809 cites W2031290591 @default.
• W2031808809 cites W2032747803 @default.
• W2031808809 cites W2034249407 @default.
• W2031808809 cites W2035006100 @default.
• W2031808809 cites W2045219286 @default.
• W2031808809 cites W2045230247 @default.
• W2031808809 cites W2049390259 @default.
• W2031808809 cites W2052022784 @default.
• W2031808809 cites W2052762706 @default.
• W2031808809 cites W2062101337 @default.
• W2031808809 cites W2063869191 @default.
• W2031808809 cites W2073023385 @default.
• W2031808809 cites W2078733777 @default.
• W2031808809 cites W2081062408 @default.
• W2031808809 cites W2090652341 @default.
• W2031808809 cites W2090704440 @default.
• W2031808809 cites W2094245705 @default.
• W2031808809 cites W2100837269 @default.
• W2031808809 cites W2114292270 @default.
• W2031808809 cites W2114671452 @default.
• W2031808809 cites W2160738923 @default.
• W2031808809 cites W2163682172 @default.
• W2031808809 cites W2163802114 @default.
• W2031808809 cites W2313156112 @default.
• W2031808809 doi "https://doi.org/10.1002/bit.1095" @default.
• W2031808809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11353411" @default.
• W2031808809 hasPublicationYear "2001" @default.
• W2031808809 type Work @default.
• W2031808809 sameAs 2031808809 @default.
• W2031808809 citedByCount "35" @default.
• W2031808809 countsByYear W20318088092012 @default.
• W2031808809 countsByYear W20318088092013 @default.
• W2031808809 countsByYear W20318088092014 @default.
• W2031808809 countsByYear W20318088092015 @default.
• W2031808809 countsByYear W20318088092021 @default.
• W2031808809 countsByYear W20318088092022 @default.
• W2031808809 crossrefType "journal-article" @default.
• W2031808809 hasAuthorship W2031808809A5028490934 @default.
• W2031808809 hasAuthorship W2031808809A5041704850 @default.
• W2031808809 hasAuthorship W2031808809A5058645779 @default.
• W2031808809 hasAuthorship W2031808809A5066064308 @default.
• W2031808809 hasAuthorship W2031808809A5077851223 @default.
• W2031808809 hasAuthorship W2031808809A5078873559 @default.
• W2031808809 hasAuthorship W2031808809A5084452013 @default.
• W2031808809 hasAuthorship W2031808809A5087178931 @default.
• W2031808809 hasAuthorship W2031808809A5088081540 @default.
• W2031808809 hasConcept C104317684 @default.
• W2031808809 hasConcept C134018914 @default.
• W2031808809 hasConcept C153911025 @default.
• W2031808809 hasConcept C159654299 @default.
• W2031808809 hasConcept C195616568 @default.
• W2031808809 hasConcept C203014093 @default.
• W2031808809 hasConcept C2777006276 @default.
• W2031808809 hasConcept C2777899865 @default.
• W2031808809 hasConcept C2778486448 @default.
• W2031808809 hasConcept C2778609137 @default.
• W2031808809 hasConcept C2779281246 @default.
• W2031808809 hasConcept C2780640218 @default.
• W2031808809 hasConcept C2780876595 @default.
• W2031808809 hasConcept C40767141 @default.
• W2031808809 hasConcept C529278444 @default.
• W2031808809 hasConcept C55493867 @default.
• W2031808809 hasConcept C7821365 @default.
• W2031808809 hasConcept C86803240 @default.
• W2031808809 hasConcept C89423630 @default.
• W2031808809 hasConceptScore W2031808809C104317684 @default.
• W2031808809 hasConceptScore W2031808809C134018914 @default.
• W2031808809 hasConceptScore W2031808809C153911025 @default.
• W2031808809 hasConceptScore W2031808809C159654299 @default.
• W2031808809 hasConceptScore W2031808809C195616568 @default.
• W2031808809 hasConceptScore W2031808809C203014093 @default.
• W2031808809 hasConceptScore W2031808809C2777006276 @default.
• W2031808809 hasConceptScore W2031808809C2777899865 @default.
• W2031808809 hasConceptScore W2031808809C2778486448 @default.

• next