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- W2031821783 abstract "Human sera were tested for their ability to inhibit 5 alpha-reductase binding of a potent inhibitor of the enzyme. Thirty one of 227 serum samples from patients diagnosed or suspected of prostatic cancer had a significant inhibitory activity, whereas 128 serum samples from other patients were inactive. The majority of the inhibitory activity was in the IgG fraction purified by chromatography on a protein A-Sepharose affinity column and an anti-human IgG-agarose column. IgG fractions from non-inhibitory sera were inactive. Inhibitory IgG also inhibited the enzymatic activity of microsomal 5 alpha-reductase from liver, ventral prostate and preputial gland of rat, and liver, prostate, and facial skin of human. The inhibitory IgG had no effect on NADH-menadione reductase or 17 beta-hydroxysteroid dehydrogenase. These results suggest that 5 alpha-reductase autoantibodies are present in the blood of some prostatic cancer patients." @default.
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- W2031821783 date "1990-12-01" @default.
- W2031821783 modified "2023-10-05" @default.
- W2031821783 title "Anti-5α-Reductase Autoantibodies in the Serum of Patients with Prostatic Cancer*" @default.
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- W2031821783 doi "https://doi.org/10.1210/jcem-71-6-1666" @default.
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