Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031840176> ?p ?o ?g. }
- W2031840176 endingPage "13977" @default.
- W2031840176 startingPage "13973" @default.
- W2031840176 abstract "Mitosin/CENP-F is a human nuclear matrix protein with multiple leucine zipper motifs. Its accumulation in S-G2 phases and transient kinetochore localization in mitosis suggest a multifunctional protein for cell proliferation. Moreover, its murine and avian orthologs are implicated in myocyte differentiation. Here we report its interaction with activating transcription factor-4 (ATF4), a ubiquitous basic leucine zipper transcription factor important for proliferation, differentiation, and stress response. The C-terminal portion of mitosin between residues 2488 and 3113 bound to ATF4 through two distinct domains, one of which was a leucine zipper motif. Mitosin mutants containing these domains were able to either supershift or disrupt the ATF4-DNA complex. On the other hand, ATF4, but not ATF1–3 or ATF6, interacted with mitosin through a region containing the basic leucine zipper motif. Moreover, overexpression of full-length mitosin repressed the transactivation activity of ATF4 in dual luciferase-based reporter assays, while knocking down mitosin expression manifested the opposite effects. These findings suggest mitosin to be a negative regulator of ATF4 in interphase through direct interaction." @default.
- W2031840176 created "2016-06-24" @default.
- W2031840176 creator A5009423336 @default.
- W2031840176 creator A5010236216 @default.
- W2031840176 creator A5019291511 @default.
- W2031840176 creator A5025826239 @default.
- W2031840176 creator A5025839290 @default.
- W2031840176 creator A5076606324 @default.
- W2031840176 creator A5078839005 @default.
- W2031840176 creator A5087788639 @default.
- W2031840176 creator A5091688695 @default.
- W2031840176 date "2005-04-01" @default.
- W2031840176 modified "2023-10-15" @default.
- W2031840176 title "Mitosin/CENP-F as a Negative Regulator of Activating Transcription Factor-4" @default.
- W2031840176 cites W1254790682 @default.
- W2031840176 cites W1519363809 @default.
- W2031840176 cites W1541178031 @default.
- W2031840176 cites W1969415325 @default.
- W2031840176 cites W1970728706 @default.
- W2031840176 cites W1984064054 @default.
- W2031840176 cites W1994539200 @default.
- W2031840176 cites W1998147517 @default.
- W2031840176 cites W2001991475 @default.
- W2031840176 cites W2004129971 @default.
- W2031840176 cites W2004855758 @default.
- W2031840176 cites W2005393972 @default.
- W2031840176 cites W2006081146 @default.
- W2031840176 cites W2013706715 @default.
- W2031840176 cites W2013906792 @default.
- W2031840176 cites W2015446431 @default.
- W2031840176 cites W2023666553 @default.
- W2031840176 cites W2036699032 @default.
- W2031840176 cites W2037088305 @default.
- W2031840176 cites W2040952209 @default.
- W2031840176 cites W2041300824 @default.
- W2031840176 cites W2053593146 @default.
- W2031840176 cites W2054421559 @default.
- W2031840176 cites W2054524462 @default.
- W2031840176 cites W2055851716 @default.
- W2031840176 cites W2065843242 @default.
- W2031840176 cites W2068176108 @default.
- W2031840176 cites W2086589468 @default.
- W2031840176 cites W2087458065 @default.
- W2031840176 cites W2090429649 @default.
- W2031840176 cites W2090962655 @default.
- W2031840176 cites W2094592535 @default.
- W2031840176 cites W2098296304 @default.
- W2031840176 cites W2100147739 @default.
- W2031840176 cites W2106492464 @default.
- W2031840176 cites W2107424534 @default.
- W2031840176 cites W2109399660 @default.
- W2031840176 cites W2120153758 @default.
- W2031840176 cites W2128967156 @default.
- W2031840176 cites W2131632095 @default.
- W2031840176 cites W2133850147 @default.
- W2031840176 cites W2146900615 @default.
- W2031840176 cites W2150560269 @default.
- W2031840176 cites W2155444606 @default.
- W2031840176 cites W2169344296 @default.
- W2031840176 cites W2333247929 @default.
- W2031840176 cites W78763444 @default.
- W2031840176 doi "https://doi.org/10.1074/jbc.m414310200" @default.
- W2031840176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15677469" @default.
- W2031840176 hasPublicationYear "2005" @default.
- W2031840176 type Work @default.
- W2031840176 sameAs 2031840176 @default.
- W2031840176 citedByCount "31" @default.
- W2031840176 countsByYear W20318401762012 @default.
- W2031840176 countsByYear W20318401762013 @default.
- W2031840176 countsByYear W20318401762016 @default.
- W2031840176 countsByYear W20318401762017 @default.
- W2031840176 countsByYear W20318401762018 @default.
- W2031840176 countsByYear W20318401762020 @default.
- W2031840176 countsByYear W20318401762023 @default.
- W2031840176 crossrefType "journal-article" @default.
- W2031840176 hasAuthorship W2031840176A5009423336 @default.
- W2031840176 hasAuthorship W2031840176A5010236216 @default.
- W2031840176 hasAuthorship W2031840176A5019291511 @default.
- W2031840176 hasAuthorship W2031840176A5025826239 @default.
- W2031840176 hasAuthorship W2031840176A5025839290 @default.
- W2031840176 hasAuthorship W2031840176A5076606324 @default.
- W2031840176 hasAuthorship W2031840176A5078839005 @default.
- W2031840176 hasAuthorship W2031840176A5087788639 @default.
- W2031840176 hasAuthorship W2031840176A5091688695 @default.
- W2031840176 hasBestOaLocation W20318401761 @default.
- W2031840176 hasConcept C104317684 @default.
- W2031840176 hasConcept C138885662 @default.
- W2031840176 hasConcept C179926584 @default.
- W2031840176 hasConcept C185592680 @default.
- W2031840176 hasConcept C3017707949 @default.
- W2031840176 hasConcept C41895202 @default.
- W2031840176 hasConcept C54355233 @default.
- W2031840176 hasConcept C62478195 @default.
- W2031840176 hasConcept C6929976 @default.
- W2031840176 hasConcept C86339819 @default.
- W2031840176 hasConcept C86803240 @default.
- W2031840176 hasConcept C95444343 @default.
- W2031840176 hasConceptScore W2031840176C104317684 @default.