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- W2031848920 endingPage "394" @default.
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- W2031848920 abstract "Photodynamic antimicrobial agents based on the well-established phenothiazinium biological stain methylene blue offer a simple method for the inactivation or destruction of pathogens contained in donated blood and blood products. The technique is currently concentrated on viruses and the disinfective procedure can be carried out in blood bags using basic low-power light sources. Pathogens of the bacterial, yeast and protozoal classes are also susceptible to phenothiaziniums. The photoantimicrobial mode of action is usually via oxidative damage to cellular components, either due to redox reactions between the agent and a biomolecular target or by the action of reactive oxygen species generated in situ by photodynamic action. The targeting of various microbial species is discussed in relation to the physicochemical make-up of the photosensitizers, and future directions are suggested." @default.
- W2031848920 created "2016-06-24" @default.
- W2031848920 creator A5053896327 @default.
- W2031848920 date "2000-12-01" @default.
- W2031848920 modified "2023-10-11" @default.
- W2031848920 title "Methylene blue derivatives — suitable photoantimicrobials for blood product disinfection?" @default.
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- W2031848920 doi "https://doi.org/10.1016/s0924-8579(00)00207-7" @default.
- W2031848920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11118846" @default.
- W2031848920 hasPublicationYear "2000" @default.
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