FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031851199> ?p ?o ?g. }

• W2031851199 endingPage "18" @default.
• W2031851199 startingPage "5" @default.
• W2031851199 abstract "Progressive retinal atrophy (PRA) is a leading hereditary cause of blindness in pedigree dogs as is its counterpart retinitis pigmentosa (RP) in humans. PRA shows genetic heterogeneity, as does RP, with several distinct forms already recognized and several more remaining to be investigated. Progress in molecular genetics has allowed the identification of the gene mutation responsible for an early onset form of PRA in the Irish setter, classified as rod-cone dysplasia type 1. The gene involved is the beta-subunit of cyclic guanosine monophosphate phosphodiesterase which encodes a protein of the visual transduction cascade. Investigation of this gene in other breeds of dog with PRA has failed to find further breeds with the same mutation. Other genes that have been investigated include those encoding other proteins in the visual transduction cascade and for photoreceptor specific structural proteins. Further disease causing mutations have not yet been identified. Recently, developments in the mapping of the canine genome have produced sufficient markers to allow preliminary mapping of PRA genes. Already linkage to the most common form of PRA, progressive rod-cone degeneration (prcd), has been established. prcd occurs in poodles, cocker spaniels and Labrador retrievers and possibly other breeds. The prcd-linked marker should enable development of a DNA-based test for the disease locus and facilitate identification of the actual disease causing gene mutation. Over the next few years we can look forward to the identification of several more PRA-causing gene mutations. This article will review research that seeks to characterize PRA in the dog, identify the responsible gene mutations, and elucidate the disease processes involved." @default.
• W2031851199 created "2016-06-24" @default.
• W2031851199 creator A5022168061 @default.
• W2031851199 date "1998-01-01" @default.
• W2031851199 modified "2023-09-23" @default.
• W2031851199 title "A review of research to elucidate the causes of thegeneralized progressive retinal atrophies" @default.
• W2031851199 cites W1791674900 @default.
• W2031851199 cites W1963607443 @default.
• W2031851199 cites W1967814955 @default.
• W2031851199 cites W1968769254 @default.
• W2031851199 cites W1969578153 @default.
• W2031851199 cites W1971321149 @default.
• W2031851199 cites W1977381415 @default.
• W2031851199 cites W1979110474 @default.
• W2031851199 cites W1986202652 @default.
• W2031851199 cites W1991151188 @default.
• W2031851199 cites W1993337495 @default.
• W2031851199 cites W1996623120 @default.
• W2031851199 cites W2002180241 @default.
• W2031851199 cites W2003963096 @default.
• W2031851199 cites W2007267826 @default.
• W2031851199 cites W2013238661 @default.
• W2031851199 cites W2014127689 @default.
• W2031851199 cites W2021868178 @default.
• W2031851199 cites W2028803712 @default.
• W2031851199 cites W2031604547 @default.
• W2031851199 cites W2038825634 @default.
• W2031851199 cites W2044562743 @default.
• W2031851199 cites W2049914565 @default.
• W2031851199 cites W2050748970 @default.
• W2031851199 cites W2059138536 @default.
• W2031851199 cites W2060948985 @default.
• W2031851199 cites W2063499365 @default.
• W2031851199 cites W2063678556 @default.
• W2031851199 cites W2064226143 @default.
• W2031851199 cites W2064838945 @default.
• W2031851199 cites W2064851008 @default.
• W2031851199 cites W2068019824 @default.
• W2031851199 cites W2068300161 @default.
• W2031851199 cites W2068825904 @default.
• W2031851199 cites W2069631518 @default.
• W2031851199 cites W2083824022 @default.
• W2031851199 cites W2086859078 @default.
• W2031851199 cites W2088614839 @default.
• W2031851199 cites W2090912192 @default.
• W2031851199 cites W2121546784 @default.
• W2031851199 cites W2307289224 @default.
• W2031851199 cites W2341723247 @default.
• W2031851199 doi "https://doi.org/10.1016/s1090-0233(98)80028-2" @default.
• W2031851199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9455155" @default.
• W2031851199 hasPublicationYear "1998" @default.
• W2031851199 type Work @default.
• W2031851199 sameAs 2031851199 @default.
• W2031851199 citedByCount "39" @default.
• W2031851199 countsByYear W20318511992013 @default.
• W2031851199 countsByYear W20318511992014 @default.
• W2031851199 countsByYear W20318511992015 @default.
• W2031851199 countsByYear W20318511992017 @default.
• W2031851199 countsByYear W20318511992018 @default.
• W2031851199 countsByYear W20318511992020 @default.
• W2031851199 crossrefType "journal-article" @default.
• W2031851199 hasAuthorship W2031851199A5022168061 @default.
• W2031851199 hasConcept C104317684 @default.
• W2031851199 hasConcept C127716648 @default.
• W2031851199 hasConcept C131667965 @default.
• W2031851199 hasConcept C169760540 @default.
• W2031851199 hasConcept C2777093970 @default.
• W2031851199 hasConcept C2781040256 @default.
• W2031851199 hasConcept C2781114197 @default.
• W2031851199 hasConcept C3020804800 @default.
• W2031851199 hasConcept C501734568 @default.
• W2031851199 hasConcept C54355233 @default.
• W2031851199 hasConcept C63971535 @default.
• W2031851199 hasConcept C64618202 @default.
• W2031851199 hasConcept C84597430 @default.
• W2031851199 hasConcept C86803240 @default.
• W2031851199 hasConceptScore W2031851199C104317684 @default.
• W2031851199 hasConceptScore W2031851199C127716648 @default.
• W2031851199 hasConceptScore W2031851199C131667965 @default.
• W2031851199 hasConceptScore W2031851199C169760540 @default.
• W2031851199 hasConceptScore W2031851199C2777093970 @default.
• W2031851199 hasConceptScore W2031851199C2781040256 @default.
• W2031851199 hasConceptScore W2031851199C2781114197 @default.
• W2031851199 hasConceptScore W2031851199C3020804800 @default.
• W2031851199 hasConceptScore W2031851199C501734568 @default.
• W2031851199 hasConceptScore W2031851199C54355233 @default.
• W2031851199 hasConceptScore W2031851199C63971535 @default.
• W2031851199 hasConceptScore W2031851199C64618202 @default.
• W2031851199 hasConceptScore W2031851199C84597430 @default.
• W2031851199 hasConceptScore W2031851199C86803240 @default.
• W2031851199 hasIssue "1" @default.
• W2031851199 hasLocation W20318511991 @default.
• W2031851199 hasLocation W20318511992 @default.
• W2031851199 hasOpenAccess W2031851199 @default.
• W2031851199 hasPrimaryLocation W20318511991 @default.
• W2031851199 hasRelatedWork W1905960701 @default.
• W2031851199 hasRelatedWork W1977132553 @default.
• W2031851199 hasRelatedWork W1988531580 @default.

• next