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• W2031872178 abstract "The production of cytokines by the immune system in response to cytosolic DNA plays an important role in host defense, autoimmune disease, and cancer immunogenicity. Recently a cytosolic DNA signaling pathway that is dependent on the endoplasmic reticulum adaptor and cyclic dinucleotide sensor protein STING has been identified. Association of cytosolic DNA with cyclic-GMP-AMP synthase (cGAS) activates its enzymatic activity to synthesize the cyclic dinucleotide second messenger cGAMP from GTP and ATP. Direct detection of cGAMP by STING triggers the activation of IRF3 and NF-kB, and the production of type I interferons and proinflammatory cytokines. The mechanism of how STING is able to mediate downstream signaling remains incompletely understood although it has been shown that dimerization is a prerequisite. Here, we identify a single amino acid change in STING that confers constitutive active signaling. This mutation appears to both enhance ability of STING to both dimerize and associate with its downstream target TBK1." @default.
• W2031872178 created "2016-06-24" @default.
• W2031872178 creator A5017121960 @default.
• W2031872178 creator A5017815821 @default.
• W2031872178 date "2015-03-19" @default.
• W2031872178 modified "2023-09-23" @default.
• W2031872178 title "Single Amino Acid Change in STING Leads to Constitutive Active Signaling" @default.
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• W2031872178 doi "https://doi.org/10.1371/journal.pone.0120090" @default.
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• W2031872178 hasPublicationYear "2015" @default.
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