Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031873311> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2031873311 startingPage "3631" @default.
- W2031873311 abstract "Background and objective: Bronchiolitis obliterans organizing pneumonia (BOOP) is a distinct clinicopathological entity histologically characterized by intra-alveolar granulation tissue and absence of extensive fibrotic lesions. Effective macrolide treatment of BOOP has been reported anecdotally. This study aimed to investigate whether alveolar macrophages (AMs) produce aberrant proinflammatory cytokines in BOOP and whether this can be inhibited by clarithromycin (CAM) or azithromycin (AZM). Methods: AMs collected by bronchoalveolar lavage (BAL) from 6 BOOP patients and 8 non-ILD controls were cultured for 24 hours in the presence or absence of CAM, AZM, lipopolysaccharide (LPS), or dexamethasone (DEX). Tumor necrosis factor alpha (TNF-α), soluble TNF receptor 1 (sTNFR1), sTNFR2, interleukin 1beta (IL-1β), IL-6, IL-8, IL-10, interferon gamma inducible protein 10 (IP-10) and CC chemokine ligand 18 (CCL18) were measured in the culture supernatant by ELISA. Results: The spontaneous and LPS-stimulated production of all investigated cytokines by AMs was significantly increased in BOOP compared to controls. CAM and AZM induced a dose-dependent suppression of spontaneous TNF-α, sTNFR2, IL-6, IL-8 and CCL18 production (p Conclusions: AMs from BOOP patients produce abundant proinflammatory cytokines which may be pivotal in the disease pathogenesis. Macrolides inhibit this cytokine production, CAM more efficiently than AZM." @default.
- W2031873311 created "2016-06-24" @default.
- W2031873311 creator A5020511016 @default.
- W2031873311 creator A5028171515 @default.
- W2031873311 creator A5038615410 @default.
- W2031873311 creator A5072326413 @default.
- W2031873311 creator A5085604392 @default.
- W2031873311 creator A5090203143 @default.
- W2031873311 date "2012-09-01" @default.
- W2031873311 modified "2023-09-26" @default.
- W2031873311 title "Macrolides inhibit cytokine production by alveolar macrophages in bronchiolitis obliterans organizing pneumonia" @default.
- W2031873311 hasPublicationYear "2012" @default.
- W2031873311 type Work @default.
- W2031873311 sameAs 2031873311 @default.
- W2031873311 citedByCount "0" @default.
- W2031873311 crossrefType "journal-article" @default.
- W2031873311 hasAuthorship W2031873311A5020511016 @default.
- W2031873311 hasAuthorship W2031873311A5028171515 @default.
- W2031873311 hasAuthorship W2031873311A5038615410 @default.
- W2031873311 hasAuthorship W2031873311A5072326413 @default.
- W2031873311 hasAuthorship W2031873311A5085604392 @default.
- W2031873311 hasAuthorship W2031873311A5090203143 @default.
- W2031873311 hasConcept C126322002 @default.
- W2031873311 hasConcept C13373296 @default.
- W2031873311 hasConcept C142724271 @default.
- W2031873311 hasConcept C164027704 @default.
- W2031873311 hasConcept C17502307 @default.
- W2031873311 hasConcept C17991360 @default.
- W2031873311 hasConcept C203014093 @default.
- W2031873311 hasConcept C2776739411 @default.
- W2031873311 hasConcept C2776914184 @default.
- W2031873311 hasConcept C2777677276 @default.
- W2031873311 hasConcept C2777714996 @default.
- W2031873311 hasConcept C2777961210 @default.
- W2031873311 hasConcept C2778690821 @default.
- W2031873311 hasConcept C2781448352 @default.
- W2031873311 hasConcept C5858377 @default.
- W2031873311 hasConcept C71924100 @default.
- W2031873311 hasConceptScore W2031873311C126322002 @default.
- W2031873311 hasConceptScore W2031873311C13373296 @default.
- W2031873311 hasConceptScore W2031873311C142724271 @default.
- W2031873311 hasConceptScore W2031873311C164027704 @default.
- W2031873311 hasConceptScore W2031873311C17502307 @default.
- W2031873311 hasConceptScore W2031873311C17991360 @default.
- W2031873311 hasConceptScore W2031873311C203014093 @default.
- W2031873311 hasConceptScore W2031873311C2776739411 @default.
- W2031873311 hasConceptScore W2031873311C2776914184 @default.
- W2031873311 hasConceptScore W2031873311C2777677276 @default.
- W2031873311 hasConceptScore W2031873311C2777714996 @default.
- W2031873311 hasConceptScore W2031873311C2777961210 @default.
- W2031873311 hasConceptScore W2031873311C2778690821 @default.
- W2031873311 hasConceptScore W2031873311C2781448352 @default.
- W2031873311 hasConceptScore W2031873311C5858377 @default.
- W2031873311 hasConceptScore W2031873311C71924100 @default.
- W2031873311 hasLocation W20318733111 @default.
- W2031873311 hasOpenAccess W2031873311 @default.
- W2031873311 hasPrimaryLocation W20318733111 @default.
- W2031873311 hasRelatedWork W1988925834 @default.
- W2031873311 hasRelatedWork W2032173473 @default.
- W2031873311 hasRelatedWork W2062611291 @default.
- W2031873311 hasRelatedWork W2074624283 @default.
- W2031873311 hasRelatedWork W2079701303 @default.
- W2031873311 hasRelatedWork W2088260949 @default.
- W2031873311 hasRelatedWork W2100689703 @default.
- W2031873311 hasRelatedWork W2123742200 @default.
- W2031873311 hasRelatedWork W2133805178 @default.
- W2031873311 hasRelatedWork W2275518964 @default.
- W2031873311 hasRelatedWork W2349075696 @default.
- W2031873311 hasRelatedWork W2399704954 @default.
- W2031873311 hasRelatedWork W2406956184 @default.
- W2031873311 hasRelatedWork W2408443487 @default.
- W2031873311 hasRelatedWork W2408695564 @default.
- W2031873311 hasRelatedWork W2422698604 @default.
- W2031873311 hasRelatedWork W2443606371 @default.
- W2031873311 hasRelatedWork W29647042 @default.
- W2031873311 hasRelatedWork W3095895854 @default.
- W2031873311 hasRelatedWork W3146329918 @default.
- W2031873311 hasVolume "40" @default.
- W2031873311 isParatext "false" @default.
- W2031873311 isRetracted "false" @default.
- W2031873311 magId "2031873311" @default.
- W2031873311 workType "article" @default.