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- W2031886846 abstract "The fruits of Cudrania tricuspidata (Carr.) Bur. (Moraceae) significantly inhibited pancreatic lipase, which plays a key role in fat absorption. Optimization of extraction conditions with minimum pancreatic lipase activity and maximum yield was determined using response surface methodology with three-level-three-factor Box-Behnken design (BBD). Regression analysis showed a good fit of the experimental data and the optimal condition was obtained as ethanol concentration, 74.5%; temperature 61.9°C and extraction time, 13.5h. The pancreatic lipase activity and extraction yield under optimal conditions were found to be 65.5% and 54.0%, respectively, which were well matched with the predicted value of 65.8% and 47.1%. Further fractionation of C. tricuspidata extract resulted in the isolation of compound 1, which was identified as 5,7,4'-trihydroxy-6,8-diprenylisoflavone. It inhibited pancreatic lipase activity with IC50 value of 65.0μM. HPLC analysis suggested positive correlation between pancreatic lipase inhibition and 5,7,4'-trihydroxy-6,8-diprenylisoflavone of C. tricuspidata fruits." @default.
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- W2031886846 date "2014-05-01" @default.
- W2031886846 modified "2023-10-16" @default.
- W2031886846 title "Optimization of pancreatic lipase inhibition by Cudrania tricuspidata fruits using response surface methodology" @default.
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- W2031886846 doi "https://doi.org/10.1016/j.bmcl.2014.03.067" @default.
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