FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031900304> ?p ?o ?g. }

• W2031900304 endingPage "1419" @default.
• W2031900304 startingPage "1412" @default.
• W2031900304 abstract "Increased mortality of patients with oral cancer largely reflects the local and regional spread of the disease. The invasiveness of these tumours requires hydrolases which are regulated through AP-1-dependent transcriptional mechanisms. Since the amount/activity of transcription factors bound to the AP-1 motif are regulated partly through the extracellular signal-regulated kinases (ERK1/ERK2), we determined the effect of PD 098059, an inhibitor of ERK1/ERK2 activation, on the in vivo invasiveness of a human squamous cell carcinoma cell line (UM-SCC-1) derived from the oral cavity. We utilized the floor of mouth musculature consisting of the mylohyoid, geniohyoid and genioglossus muscle (which are sequentially arranged), as a natural barrier to assess tumour spread in vivo in the nude mouse. Mice were inoculated with tumour cells superficial to the mylohyoid muscle. After 18 days, tumours were injected with either empty liposomes (control) or liposomes containing 5 microM PD 098059 and, after an additional 22 days, the jaws of mice examined histologically. Highly infiltrative tumours, which had penetrated the genioglossus muscle, were evident in 10/12 control mice. In contrast, in 9/12 mice in which the tumours were injected with PD 098059, tumours did not extend beyond the mylohyoid or geniohyoid muscles. Tumours penetrated bone nutrient canals in 7/12 control mice but in only 3/12 PD 098059-treated mice. Neurotropism, characteristic of aggressive oral squamous cell carcinoma, was evident in 6/12 control mice but was completely abolished (0/12 mice) in the PD 098059-treated mice. Using a staging system based on the muscle layer involved, neurotropism, as well as bone involvement, we found the inhibition of invasion to be statistically significant (P < 0.01). The reduced invasiveness of the PD 098059-liposome-treated oral cancers was associated with diminished 92-kDa type IV collagenase and ERK1/ERK2 activities but was not a consequence of a slower tumour growth rate. This is the first study to demonstrate reduced in vivo invasiveness of a malignancy brought about by an inhibitor of ERK1/ERK2 activation. These results raise the exciting possibility that second generation PD 098059 congeners may reduce the spread of the disease in patients afflicted with oral cancers." @default.
• W2031900304 created "2016-06-24" @default.
• W2031900304 creator A5004019711 @default.
• W2031900304 creator A5015308351 @default.
• W2031900304 creator A5015488796 @default.
• W2031900304 creator A5036412023 @default.
• W2031900304 creator A5057978718 @default.
• W2031900304 creator A5069774197 @default.
• W2031900304 creator A5076494212 @default.
• W2031900304 creator A5084442354 @default.
• W2031900304 date "1999-06-11" @default.
• W2031900304 modified "2023-10-12" @default.
• W2031900304 title "PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma" @default.
• W2031900304 cites W137936598 @default.
• W2031900304 cites W1517150667 @default.
• W2031900304 cites W1521352631 @default.
• W2031900304 cites W1545152283 @default.
• W2031900304 cites W1554133437 @default.
• W2031900304 cites W1561043766 @default.
• W2031900304 cites W1567487285 @default.
• W2031900304 cites W1573411722 @default.
• W2031900304 cites W1575281088 @default.
• W2031900304 cites W1585336990 @default.
• W2031900304 cites W1599282089 @default.
• W2031900304 cites W1660300003 @default.
• W2031900304 cites W1669342624 @default.
• W2031900304 cites W1794257889 @default.
• W2031900304 cites W1964201687 @default.
• W2031900304 cites W1969191130 @default.
• W2031900304 cites W1971915141 @default.
• W2031900304 cites W1972153522 @default.
• W2031900304 cites W1977302628 @default.
• W2031900304 cites W1983475354 @default.
• W2031900304 cites W1987339712 @default.
• W2031900304 cites W1989170373 @default.
• W2031900304 cites W1999157780 @default.
• W2031900304 cites W2003411699 @default.
• W2031900304 cites W2009426565 @default.
• W2031900304 cites W2025993620 @default.
• W2031900304 cites W2031160500 @default.
• W2031900304 cites W2035936653 @default.
• W2031900304 cites W2044420109 @default.
• W2031900304 cites W2056274413 @default.
• W2031900304 cites W2057126981 @default.
• W2031900304 cites W2060138882 @default.
• W2031900304 cites W2074254324 @default.
• W2031900304 cites W2091857312 @default.
• W2031900304 cites W2095365445 @default.
• W2031900304 cites W2095498651 @default.
• W2031900304 cites W2096910536 @default.
• W2031900304 cites W2114918609 @default.
• W2031900304 cites W2120023582 @default.
• W2031900304 cites W2135092755 @default.
• W2031900304 cites W2162333016 @default.
• W2031900304 cites W2317224850 @default.
• W2031900304 cites W2329029967 @default.
• W2031900304 cites W2418318938 @default.
• W2031900304 cites W2444477924 @default.
• W2031900304 cites W4243472019 @default.
• W2031900304 doi "https://doi.org/10.1038/sj.bjc.6690537" @default.
• W2031900304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2363077" @default.
• W2031900304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10424744" @default.
• W2031900304 hasPublicationYear "1999" @default.
• W2031900304 type Work @default.
• W2031900304 sameAs 2031900304 @default.
• W2031900304 citedByCount "51" @default.
• W2031900304 countsByYear W20319003042012 @default.
• W2031900304 countsByYear W20319003042013 @default.
• W2031900304 countsByYear W20319003042015 @default.
• W2031900304 countsByYear W20319003042018 @default.
• W2031900304 countsByYear W20319003042020 @default.
• W2031900304 countsByYear W20319003042021 @default.
• W2031900304 countsByYear W20319003042022 @default.
• W2031900304 countsByYear W20319003042023 @default.
• W2031900304 crossrefType "journal-article" @default.
• W2031900304 hasAuthorship W2031900304A5004019711 @default.
• W2031900304 hasAuthorship W2031900304A5015308351 @default.
• W2031900304 hasAuthorship W2031900304A5015488796 @default.
• W2031900304 hasAuthorship W2031900304A5036412023 @default.
• W2031900304 hasAuthorship W2031900304A5057978718 @default.
• W2031900304 hasAuthorship W2031900304A5069774197 @default.
• W2031900304 hasAuthorship W2031900304A5076494212 @default.
• W2031900304 hasAuthorship W2031900304A5084442354 @default.
• W2031900304 hasBestOaLocation W20319003041 @default.
• W2031900304 hasConcept C105702510 @default.
• W2031900304 hasConcept C142724271 @default.
• W2031900304 hasConcept C150903083 @default.
• W2031900304 hasConcept C207001950 @default.
• W2031900304 hasConcept C2777546739 @default.
• W2031900304 hasConcept C2778670693 @default.
• W2031900304 hasConcept C2779744641 @default.
• W2031900304 hasConcept C3019992690 @default.
• W2031900304 hasConcept C71924100 @default.
• W2031900304 hasConcept C86803240 @default.
• W2031900304 hasConceptScore W2031900304C105702510 @default.
• W2031900304 hasConceptScore W2031900304C142724271 @default.
• W2031900304 hasConceptScore W2031900304C150903083 @default.
• W2031900304 hasConceptScore W2031900304C207001950 @default.

• next