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- W2031904940 endingPage "357" @default.
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- W2031904940 abstract "We recently described that in the metastasizing rat pancreatic carcinoma line BSp73ASML the cell-cell adhesion molecule EpCAM, CD44 variant isoforms and the tetraspanins D6.1A and CD9 form a complex that is located in glycolipid-enriched membrane microdomains. This complex contains, in addition, an undefined 20 kDa protein. As such complex formation influenced cell-cell adhesion and apoptosis resistance, it became of interest to identify the 20 kDa polypeptide. This 20 kDa protein, which co-precipitated with EpCAM in BSp73ASML lysates, was identified as the tight junction protein claudin-7. Correspondingly, an association between EpCAM and claudin-7 was noted in rat and human tumors and in non-transformed tissues of the gastrointestinal tract. Co-localization of the two molecules was most pronounced at basolateral membranes, but was also observed in tight junctions. Evidence for direct protein-protein interactions between EpCAM and claudin-7 was obtained by co-immunoprecipitation after treatment of tumor cells with a membrane-permeable chemical cross-linker. The complex, which is located in glycolipid-enriched membrane microdomains, is not disrupted by partial cholesterol depletion, but claudin-7 phosphorylation is restricted to the localization in glycolipid-enriched membrane microdomains. This is the first report on an association between EpCAM and claudins in both non-transformed tissues and metastasizing tumor cell lines." @default.
- W2031904940 created "2016-06-24" @default.
- W2031904940 creator A5035960323 @default.
- W2031904940 creator A5038551333 @default.
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- W2031904940 creator A5083171620 @default.
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- W2031904940 date "2005-10-01" @default.
- W2031904940 modified "2023-09-24" @default.
- W2031904940 title "The cell–cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7" @default.
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- W2031904940 doi "https://doi.org/10.1016/j.yexcr.2005.06.013" @default.