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• W2031922040 startingPage "308" @default.
• W2031922040 abstract "Although acetylcholine (ACh) is well known for its neurotransmitter function, recent studies have indicated that it also functions as an immune cytokine that prevents macrophage activation through a ‘cholinergic (nicotinic) anti-inflammatory pathway’. In this study, we used the macrophage-like U937 cells to elucidate the mechanisms of the physiologic control of cytokine production by auto/paracrine ACh through the nicotinic class of ACh receptors (nAChRs) expressed in these cells. Stimulation of cells with lipopolysaccharide up-regulated expression of α1, α4, α5, α7, α10, β1 and β3 subunits, down-regulated α6 and β2 subunits, and did not alter the relative quantity of α9 and β4 mRNAs. Distinct nAChR subtypes showed differential regulation of the production of pro- and anti-inflammatory cytokines. While inhibition of the expression of the TNF-α gene was mediated predominantly by the α-bungarotoxin sensitive nAChRs, that of the IL-6 and IL-18 genes—by the mecamylamine-sensitive nAChRs. Both the Mec- and αBtx-sensitive nAChRs regulated expression of the IL-1β gene equally efficiently. Upregulation of IL-10 production by auto/paracrine ACh was mediated predominantly through α7 nAChR. These findings offer a new insight on how nicotinic agonists control inflammation, thus laying a groundwork for the development of novel immunomodulatory therapies based on the nAChR subtype selectivity of nicotinic agonists." @default.
• W2031922040 created "2016-06-24" @default.
• W2031922040 creator A5032830414 @default.
• W2031922040 creator A5040607634 @default.
• W2031922040 creator A5046808887 @default.
• W2031922040 creator A5059337810 @default.
• W2031922040 date "2010-03-01" @default.
• W2031922040 modified "2023-09-26" @default.
• W2031922040 title "Auto/paracrine control of inflammatory cytokines by acetylcholine in macrophage-like U937 cells through nicotinic receptors" @default.
• W2031922040 cites W1481879910 @default.
• W2031922040 cites W1544301323 @default.
• W2031922040 cites W1589489947 @default.
• W2031922040 cites W1594018550 @default.
• W2031922040 cites W1661316494 @default.
• W2031922040 cites W1661544713 @default.
• W2031922040 cites W1774449786 @default.
• W2031922040 cites W1899804292 @default.
• W2031922040 cites W1957468140 @default.
• W2031922040 cites W1966059342 @default.
• W2031922040 cites W1967046155 @default.
• W2031922040 cites W1967372050 @default.
• W2031922040 cites W1970696259 @default.
• W2031922040 cites W1974896225 @default.
• W2031922040 cites W1979944645 @default.
• W2031922040 cites W1985240193 @default.
• W2031922040 cites W1986356926 @default.
• W2031922040 cites W1990264320 @default.
• W2031922040 cites W1991458707 @default.
• W2031922040 cites W1991463185 @default.
• W2031922040 cites W1993620441 @default.
• W2031922040 cites W1994433769 @default.
• W2031922040 cites W2002818848 @default.
• W2031922040 cites W2004683173 @default.
• W2031922040 cites W2006397050 @default.
• W2031922040 cites W2008983312 @default.
• W2031922040 cites W2011895411 @default.
• W2031922040 cites W2023370536 @default.
• W2031922040 cites W2025857946 @default.
• W2031922040 cites W2026672721 @default.
• W2031922040 cites W2027733541 @default.
• W2031922040 cites W2041994345 @default.
• W2031922040 cites W2042821764 @default.
• W2031922040 cites W2045369887 @default.
• W2031922040 cites W2048615211 @default.
• W2031922040 cites W2053786245 @default.
• W2031922040 cites W2058499042 @default.
• W2031922040 cites W2062419094 @default.
• W2031922040 cites W2062780494 @default.
• W2031922040 cites W2066085139 @default.
• W2031922040 cites W2068081524 @default.
• W2031922040 cites W2069202433 @default.
• W2031922040 cites W2069368135 @default.
• W2031922040 cites W2072292752 @default.
• W2031922040 cites W2073295417 @default.
• W2031922040 cites W2079096246 @default.
• W2031922040 cites W2079212663 @default.
• W2031922040 cites W2083906701 @default.
• W2031922040 cites W2084286451 @default.
• W2031922040 cites W2085637535 @default.
• W2031922040 cites W2086246203 @default.
• W2031922040 cites W2087357545 @default.
• W2031922040 cites W2088370039 @default.
• W2031922040 cites W2089681648 @default.
• W2031922040 cites W2095092649 @default.
• W2031922040 cites W2098655301 @default.
• W2031922040 cites W2100327483 @default.
• W2031922040 cites W2123928697 @default.
• W2031922040 cites W2126343491 @default.
• W2031922040 cites W2130514108 @default.
• W2031922040 cites W2131308515 @default.
• W2031922040 cites W2133764756 @default.
• W2031922040 cites W2135917172 @default.
• W2031922040 cites W2138895085 @default.
• W2031922040 cites W2145080987 @default.
• W2031922040 cites W2147285542 @default.
• W2031922040 cites W2151660617 @default.
• W2031922040 cites W2154170498 @default.
• W2031922040 cites W2156897641 @default.
• W2031922040 cites W2161605623 @default.
• W2031922040 cites W2167567269 @default.
• W2031922040 cites W2168123250 @default.
• W2031922040 cites W2170725202 @default.
• W2031922040 cites W2170822548 @default.
• W2031922040 cites W2248773438 @default.
• W2031922040 cites W2285440636 @default.
• W2031922040 cites W2336735886 @default.
• W2031922040 cites W2951178485 @default.
• W2031922040 cites W87802881 @default.
• W2031922040 doi "https://doi.org/10.1016/j.intimp.2009.12.001" @default.
• W2031922040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2829366" @default.
• W2031922040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20004742" @default.
• W2031922040 hasPublicationYear "2010" @default.
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