FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031954741> ?p ?o ?g. }

• W2031954741 endingPage "256" @default.
• W2031954741 startingPage "250" @default.
• W2031954741 abstract "Bone morphogenetic proteins (BMPs) are multifunctional regulators of proliferation, differentiation and apoptosis. BMP-6 is involved in numerous developmental processes. We have demonstrated expression of BMP-6 in breast cancer cell lines by RT-PCR and immuno-histochemistry. The level of BMP-6 mRNA decreased upon serum starvation, whereas epidermal growth factor (EGF) treatment led to elevation of BMP-6 mRNA levels in a dose-dependent manner, with a maximum at 50 ng/ml EGF under serum-free conditions in hormone-sensitive (MCF-7) and in hormone-insensitive (SK-BR-3) breast cancer cell lines. The EGF-like growth factors transforming growth factor-α, amphiregulin and betacellulin were also able to elevate the BMP-6 mRNA level after 24 hr. Inhibition of EGF receptor tyrosine kinase with tyrphostine AG1517 repressed the inductive effect of these growth factors, indicating an EGF receptor-mediated regulation of BMP-6 mRNA. In addition, BMP-6 mRNA was detected in tumor samples from breast carcinoma patients. However, levels were reduced in 18/44 samples compared with tumor-free resection margins. In 12 of these 18 patients, at least a 10-fold reduction of EGF receptor mRNA levels in tumor samples vs. tumor-free samples was observed. This suggests a putative relationship between EGF receptor and BMP-6 mRNA levels in breast cancer. Int. J. Cancer 80:250–256, 1999. © 1999 Wiley-Liss, Inc." @default.
• W2031954741 created "2016-06-24" @default.
• W2031954741 creator A5012183393 @default.
• W2031954741 creator A5053325816 @default.
• W2031954741 creator A5064770654 @default.
• W2031954741 date "1999-01-18" @default.
• W2031954741 modified "2023-09-26" @default.
• W2031954741 title "Expression of bone morphogenetic protein 6 in normal mammary tissue and breast cancer cell lines and its regulation by epidermal growth factor" @default.
• W2031954741 cites W1663371441 @default.
• W2031954741 cites W1698663755 @default.
• W2031954741 cites W1968822620 @default.
• W2031954741 cites W1969916098 @default.
• W2031954741 cites W1975828859 @default.
• W2031954741 cites W1986469118 @default.
• W2031954741 cites W1988976538 @default.
• W2031954741 cites W2003396164 @default.
• W2031954741 cites W2008380967 @default.
• W2031954741 cites W2008940139 @default.
• W2031954741 cites W2054351138 @default.
• W2031954741 cites W2055110202 @default.
• W2031954741 cites W2069637592 @default.
• W2031954741 cites W2081765669 @default.
• W2031954741 cites W2095569986 @default.
• W2031954741 cites W2096428903 @default.
• W2031954741 cites W2113331004 @default.
• W2031954741 cites W2113799480 @default.
• W2031954741 cites W2114543718 @default.
• W2031954741 cites W2123221507 @default.
• W2031954741 cites W2165152498 @default.
• W2031954741 cites W2234549232 @default.
• W2031954741 cites W4293247451 @default.
• W2031954741 doi "https://doi.org/10.1002/(sici)1097-0215(19990118)80:2<250::aid-ijc14>3.0.co;2-d" @default.
• W2031954741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9935207" @default.
• W2031954741 hasPublicationYear "1999" @default.
• W2031954741 type Work @default.
• W2031954741 sameAs 2031954741 @default.
• W2031954741 citedByCount "62" @default.
• W2031954741 countsByYear W20319547412012 @default.
• W2031954741 countsByYear W20319547412013 @default.
• W2031954741 countsByYear W20319547412015 @default.
• W2031954741 countsByYear W20319547412016 @default.
• W2031954741 countsByYear W20319547412017 @default.
• W2031954741 countsByYear W20319547412018 @default.
• W2031954741 countsByYear W20319547412019 @default.
• W2031954741 countsByYear W20319547412020 @default.
• W2031954741 countsByYear W20319547412022 @default.
• W2031954741 countsByYear W20319547412023 @default.
• W2031954741 crossrefType "journal-article" @default.
• W2031954741 hasAuthorship W2031954741A5012183393 @default.
• W2031954741 hasAuthorship W2031954741A5053325816 @default.
• W2031954741 hasAuthorship W2031954741A5064770654 @default.
• W2031954741 hasBestOaLocation W20319547411 @default.
• W2031954741 hasConcept C104317684 @default.
• W2031954741 hasConcept C121608353 @default.
• W2031954741 hasConcept C126322002 @default.
• W2031954741 hasConcept C134018914 @default.
• W2031954741 hasConcept C170493617 @default.
• W2031954741 hasConcept C2775960820 @default.
• W2031954741 hasConcept C2776362946 @default.
• W2031954741 hasConcept C2779438470 @default.
• W2031954741 hasConcept C2780806702 @default.
• W2031954741 hasConcept C31507581 @default.
• W2031954741 hasConcept C502942594 @default.
• W2031954741 hasConcept C530470458 @default.
• W2031954741 hasConcept C55493867 @default.
• W2031954741 hasConcept C71924100 @default.
• W2031954741 hasConcept C86803240 @default.
• W2031954741 hasConceptScore W2031954741C104317684 @default.
• W2031954741 hasConceptScore W2031954741C121608353 @default.
• W2031954741 hasConceptScore W2031954741C126322002 @default.
• W2031954741 hasConceptScore W2031954741C134018914 @default.
• W2031954741 hasConceptScore W2031954741C170493617 @default.
• W2031954741 hasConceptScore W2031954741C2775960820 @default.
• W2031954741 hasConceptScore W2031954741C2776362946 @default.
• W2031954741 hasConceptScore W2031954741C2779438470 @default.
• W2031954741 hasConceptScore W2031954741C2780806702 @default.
• W2031954741 hasConceptScore W2031954741C31507581 @default.
• W2031954741 hasConceptScore W2031954741C502942594 @default.
• W2031954741 hasConceptScore W2031954741C530470458 @default.
• W2031954741 hasConceptScore W2031954741C55493867 @default.
• W2031954741 hasConceptScore W2031954741C71924100 @default.
• W2031954741 hasConceptScore W2031954741C86803240 @default.
• W2031954741 hasIssue "2" @default.
• W2031954741 hasLocation W20319547411 @default.
• W2031954741 hasLocation W20319547412 @default.
• W2031954741 hasOpenAccess W2031954741 @default.
• W2031954741 hasPrimaryLocation W20319547411 @default.
• W2031954741 hasRelatedWork W1977487351 @default.
• W2031954741 hasRelatedWork W2018368842 @default.
• W2031954741 hasRelatedWork W2021560856 @default.
• W2031954741 hasRelatedWork W2032639135 @default.
• W2031954741 hasRelatedWork W2034583712 @default.
• W2031954741 hasRelatedWork W2044826694 @default.
• W2031954741 hasRelatedWork W2058424427 @default.
• W2031954741 hasRelatedWork W2059196563 @default.
• W2031954741 hasRelatedWork W2063619316 @default.
• W2031954741 hasRelatedWork W2144562624 @default.
• W2031954741 hasVolume "80" @default.

• next