FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031963012> ?p ?o ?g. }

• W2031963012 endingPage "e79814" @default.
• W2031963012 startingPage "e79814" @default.
• W2031963012 abstract "Ischemia/reperfusion (I/R) injury is a common cause of injury to target organs such as brain, heart, and kidneys. Renal injury from I/R, which may occur in renal transplantation, surgery, trauma, or sepsis, is known to be an important cause of acute kidney injury. The detailed molecular mechanism of renal I/R injury is still not fully clear. Here, we investigate the role of AMP-activated protein kinase (AMPK)-evoked autophagy in the renal proximal tubular cell death in an in vitro I/R injury model. To mimic in vivo renal I/R injury, LLC-PK1 cells, a renal tubular cell line derived from pig kidney, were treated with antimycin A and 2-deoxyglucose to mimic ischemia injury followed by reperfusion with growth medium. This I/R injury model markedly induced apoptosis and autophagy in LLC-PK1 cells in a time-dependent manner. Autophagy inhibitor 3-methyladenine (3MA) significantly enhanced I/R injury-induced apoptosis. I/R could also up-regulate the phosphorylation of AMPK and down-regulate the phosphorylation of mammalian target of rapamycin (mTOR). Cells transfected with small hairpin RNA (shRNA) for AMPK significantly increased the phosphorylation of mTOR as well as decreased the induction of autophagy followed by enhancing cell apoptosis during I/R. Moreover, the mTOR inhibitor RAD001 significantly enhanced autophagy and attenuated cell apoptosis during I/R. Taken together, these findings suggest that autophagy induction protects renal tubular cell injury via an AMPK-regulated mTOR pathway in an in vitro I/R injury model. AMPK-evoked autophagy may be as a potential target for therapeutic intervention in I/R renal injury." @default.
• W2031963012 created "2016-06-24" @default.
• W2031963012 creator A5012580384 @default.
• W2031963012 creator A5026302630 @default.
• W2031963012 creator A5032584805 @default.
• W2031963012 creator A5050661792 @default.
• W2031963012 creator A5054256850 @default.
• W2031963012 creator A5073043891 @default.
• W2031963012 date "2013-11-06" @default.
• W2031963012 modified "2023-09-26" @default.
• W2031963012 title "Protective Role of AMP-Activated Protein Kinase-Evoked Autophagy on an In Vitro Model of Ischemia/Reperfusion-Induced Renal Tubular Cell Injury" @default.
• W2031963012 cites W1525984439 @default.
• W2031963012 cites W1527769554 @default.
• W2031963012 cites W1560977824 @default.
• W2031963012 cites W1963521777 @default.
• W2031963012 cites W1968984653 @default.
• W2031963012 cites W1973432709 @default.
• W2031963012 cites W1991874524 @default.
• W2031963012 cites W1992459266 @default.
• W2031963012 cites W1992995831 @default.
• W2031963012 cites W1996404449 @default.
• W2031963012 cites W1996704811 @default.
• W2031963012 cites W1999027333 @default.
• W2031963012 cites W2003899957 @default.
• W2031963012 cites W2007410147 @default.
• W2031963012 cites W2024184215 @default.
• W2031963012 cites W2033158597 @default.
• W2031963012 cites W2033765773 @default.
• W2031963012 cites W2034853531 @default.
• W2031963012 cites W2038000923 @default.
• W2031963012 cites W2039237674 @default.
• W2031963012 cites W2039713273 @default.
• W2031963012 cites W2041538521 @default.
• W2031963012 cites W2061600319 @default.
• W2031963012 cites W2070224555 @default.
• W2031963012 cites W2079213503 @default.
• W2031963012 cites W2083849298 @default.
• W2031963012 cites W2085622604 @default.
• W2031963012 cites W2087920955 @default.
• W2031963012 cites W2088970299 @default.
• W2031963012 cites W2094719535 @default.
• W2031963012 cites W2096317893 @default.
• W2031963012 cites W2097668381 @default.
• W2031963012 cites W2102973291 @default.
• W2031963012 cites W2109559593 @default.
• W2031963012 cites W2110960199 @default.
• W2031963012 cites W2117042603 @default.
• W2031963012 cites W2119041481 @default.
• W2031963012 cites W2127984419 @default.
• W2031963012 cites W2136124373 @default.
• W2031963012 cites W2137147521 @default.
• W2031963012 cites W2139987952 @default.
• W2031963012 cites W2143378104 @default.
• W2031963012 cites W2148216806 @default.
• W2031963012 cites W2149202899 @default.
• W2031963012 cites W2170880090 @default.
• W2031963012 doi "https://doi.org/10.1371/journal.pone.0079814" @default.
• W2031963012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3819246" @default.
• W2031963012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24223196" @default.
• W2031963012 hasPublicationYear "2013" @default.
• W2031963012 type Work @default.
• W2031963012 sameAs 2031963012 @default.
• W2031963012 citedByCount "51" @default.
• W2031963012 countsByYear W20319630122014 @default.
• W2031963012 countsByYear W20319630122015 @default.
• W2031963012 countsByYear W20319630122016 @default.
• W2031963012 countsByYear W20319630122017 @default.
• W2031963012 countsByYear W20319630122018 @default.
• W2031963012 countsByYear W20319630122019 @default.
• W2031963012 countsByYear W20319630122020 @default.
• W2031963012 countsByYear W20319630122021 @default.
• W2031963012 countsByYear W20319630122022 @default.
• W2031963012 countsByYear W20319630122023 @default.
• W2031963012 crossrefType "journal-article" @default.
• W2031963012 hasAuthorship W2031963012A5012580384 @default.
• W2031963012 hasAuthorship W2031963012A5026302630 @default.
• W2031963012 hasAuthorship W2031963012A5032584805 @default.
• W2031963012 hasAuthorship W2031963012A5050661792 @default.
• W2031963012 hasAuthorship W2031963012A5054256850 @default.
• W2031963012 hasAuthorship W2031963012A5073043891 @default.
• W2031963012 hasBestOaLocation W20319630121 @default.
• W2031963012 hasConcept C126322002 @default.
• W2031963012 hasConcept C184235292 @default.
• W2031963012 hasConcept C185592680 @default.
• W2031963012 hasConcept C190283241 @default.
• W2031963012 hasConcept C203522944 @default.
• W2031963012 hasConcept C2780114680 @default.
• W2031963012 hasConcept C2780124434 @default.
• W2031963012 hasConcept C541997718 @default.
• W2031963012 hasConcept C55493867 @default.
• W2031963012 hasConcept C62478195 @default.
• W2031963012 hasConcept C71924100 @default.
• W2031963012 hasConcept C86554907 @default.
• W2031963012 hasConcept C86803240 @default.
• W2031963012 hasConcept C95444343 @default.
• W2031963012 hasConcept C97029542 @default.
• W2031963012 hasConceptScore W2031963012C126322002 @default.
• W2031963012 hasConceptScore W2031963012C184235292 @default.

• next