FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031963661> ?p ?o ?g. }

• W2031963661 abstract "Y-700, a novel xanthine oxidase inhibitor, was recently developed for the treatment of hyperuricemia and gout. Since the major elimination route of this compound is hepatic metabolism and excretion, the aim of the present study was to characterize the uptake mechanism of Y-700 in the liver, which is also the pharmacological target of Y-700. Efficient uptake of Y-700 was observed both in the liver in vivo and in isolated rat hepatocytes. The uptake was Na(+)-dependent, saturable and inhibited both by ATP-depressants and various organic anions. Indomethacin competitively inhibited Y-700 uptake, whereas the inhibitory effect of organic cations and nucleosides was not so remarkable. Saturable and Na(+)-dependent uptake of Y-700 was also observed in freshly isolated human hepatocytes. Uptake of Y-700 by sinusoidal membrane transporters, such as organic anion transporter (Oat) 2 and organic anion transporting polypeptide (OATP)-B, OATP-C, OATP-8, and Oatp1, could not be detected although uptake of Y-700 in the oocytes expressing sodium/taurocholate cotransporting polypeptide (NTCP) was slightly observed. In conclusion, active transport system(s), which specifically recognize certain types of anionic compounds, are involved in the hepatic uptake of Y-700 and, at least partially, relevant to its elimination from the circulation as well as delivery to pharmacological target." @default.
• W2031963661 created "2016-06-24" @default.
• W2031963661 creator A5007544311 @default.
• W2031963661 creator A5010368815 @default.
• W2031963661 creator A5026595203 @default.
• W2031963661 creator A5026770912 @default.
• W2031963661 creator A5051094265 @default.
• W2031963661 creator A5052348746 @default.
• W2031963661 creator A5053345769 @default.
• W2031963661 creator A5062417379 @default.
• W2031963661 creator A5063611864 @default.
• W2031963661 creator A5070375754 @default.
• W2031963661 creator A5087649208 @default.
• W2031963661 date "2006-02-01" @default.
• W2031963661 modified "2023-09-25" @default.
• W2031963661 title "Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700" @default.
• W2031963661 cites W1551662159 @default.
• W2031963661 cites W170029080 @default.
• W2031963661 cites W1969856573 @default.
• W2031963661 cites W1970576651 @default.
• W2031963661 cites W1970999561 @default.
• W2031963661 cites W1996402420 @default.
• W2031963661 cites W2011548686 @default.
• W2031963661 cites W2015349672 @default.
• W2031963661 cites W2052404366 @default.
• W2031963661 cites W2071878521 @default.
• W2031963661 cites W2076385318 @default.
• W2031963661 cites W2079307415 @default.
• W2031963661 cites W2081750550 @default.
• W2031963661 cites W2087526401 @default.
• W2031963661 cites W2088776629 @default.
• W2031963661 cites W2096136187 @default.
• W2031963661 cites W2125748363 @default.
• W2031963661 cites W2135912891 @default.
• W2031963661 cites W2139121124 @default.
• W2031963661 cites W2143189887 @default.
• W2031963661 cites W2144496194 @default.
• W2031963661 cites W2145869500 @default.
• W2031963661 cites W2160034626 @default.
• W2031963661 cites W2165786577 @default.
• W2031963661 cites W2168447335 @default.
• W2031963661 cites W4293247451 @default.
• W2031963661 doi "https://doi.org/10.1002/jps.20540" @default.
• W2031963661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16369928" @default.
• W2031963661 hasPublicationYear "2006" @default.
• W2031963661 type Work @default.
• W2031963661 sameAs 2031963661 @default.
• W2031963661 citedByCount "4" @default.
• W2031963661 countsByYear W20319636612015 @default.
• W2031963661 crossrefType "journal-article" @default.
• W2031963661 hasAuthorship W2031963661A5007544311 @default.
• W2031963661 hasAuthorship W2031963661A5010368815 @default.
• W2031963661 hasAuthorship W2031963661A5026595203 @default.
• W2031963661 hasAuthorship W2031963661A5026770912 @default.
• W2031963661 hasAuthorship W2031963661A5051094265 @default.
• W2031963661 hasAuthorship W2031963661A5052348746 @default.
• W2031963661 hasAuthorship W2031963661A5053345769 @default.
• W2031963661 hasAuthorship W2031963661A5062417379 @default.
• W2031963661 hasAuthorship W2031963661A5063611864 @default.
• W2031963661 hasAuthorship W2031963661A5070375754 @default.
• W2031963661 hasAuthorship W2031963661A5087649208 @default.
• W2031963661 hasConcept C10146269 @default.
• W2031963661 hasConcept C104317684 @default.
• W2031963661 hasConcept C121421483 @default.
• W2031963661 hasConcept C123584848 @default.
• W2031963661 hasConcept C145148216 @default.
• W2031963661 hasConcept C149011108 @default.
• W2031963661 hasConcept C150903083 @default.
• W2031963661 hasConcept C178790620 @default.
• W2031963661 hasConcept C185592680 @default.
• W2031963661 hasConcept C207001950 @default.
• W2031963661 hasConcept C2776678969 @default.
• W2031963661 hasConcept C2776769776 @default.
• W2031963661 hasConcept C2779721657 @default.
• W2031963661 hasConcept C2779881121 @default.
• W2031963661 hasConcept C55493867 @default.
• W2031963661 hasConcept C62231903 @default.
• W2031963661 hasConcept C86803240 @default.
• W2031963661 hasConcept C98274493 @default.
• W2031963661 hasConceptScore W2031963661C10146269 @default.
• W2031963661 hasConceptScore W2031963661C104317684 @default.
• W2031963661 hasConceptScore W2031963661C121421483 @default.
• W2031963661 hasConceptScore W2031963661C123584848 @default.
• W2031963661 hasConceptScore W2031963661C145148216 @default.
• W2031963661 hasConceptScore W2031963661C149011108 @default.
• W2031963661 hasConceptScore W2031963661C150903083 @default.
• W2031963661 hasConceptScore W2031963661C178790620 @default.
• W2031963661 hasConceptScore W2031963661C185592680 @default.
• W2031963661 hasConceptScore W2031963661C207001950 @default.
• W2031963661 hasConceptScore W2031963661C2776678969 @default.
• W2031963661 hasConceptScore W2031963661C2776769776 @default.
• W2031963661 hasConceptScore W2031963661C2779721657 @default.
• W2031963661 hasConceptScore W2031963661C2779881121 @default.
• W2031963661 hasConceptScore W2031963661C55493867 @default.
• W2031963661 hasConceptScore W2031963661C62231903 @default.
• W2031963661 hasConceptScore W2031963661C86803240 @default.
• W2031963661 hasConceptScore W2031963661C98274493 @default.
• W2031963661 hasLocation W20319636611 @default.
• W2031963661 hasLocation W20319636612 @default.
• W2031963661 hasOpenAccess W2031963661 @default.

• next