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- W2031964146 abstract "Numerous methods have been employed to minimize the cardiotoxic effects of the chemotherapeutic agent doxorubicin (DOX), and most have had minimal success. Chronic endurance exercise, however, has previously been shown to protect against DOX cardiotoxicity, but very little is known regarding the effects of short-term exercise on DOX-induced cardiac dysfunction. PURPOSE: To investigate the effects of short-term voluntary running activity performed 1, 3, or 5 days prior to DOX administration, on cardiac function. METHODS: Female Sprague-Dawley rats (n=80) were randomly assigned to 1 of 2 primary experimental groups: sedentary (SED) or voluntary wheel running (VOL). Animals in VOL groups were housed in cages equipped with a commercially available running wheel for 1 (1VOL), 3 (3VOL), or 5 (5VOL) days. Following the activity period, animals in each group were randomly assigned to receive either 10 mg·kg-1 DOX (1VOL+DOX, 3VOL+DOX, 5VOL+DOX, SED+DOX) or saline (1VOL+SAL, 3VOL+SAL, 5VOL+SAL, SED+SAL). Left ventricle function was assessed ex vivo using an isolated working heart model 5 days post DOX exposure. RESULTS: Doxorubicin treatment alone (SED+DOX) promoted a significant decline in left ventricular developed pressure (LVDP, -17%), and the maximal rate of left ventricular development (dP/dtmax, -13%) when compared to SED+SAL (p<0.05). Short-term voluntary exercise 1, 3, and 5 d prior to DOX treatment, however, had a cardioprotective effect as, LVDP and dP/dtmax, were not significantly lower in 1VOL+DOX, 3VOL+DOX, and 5VOL+DOX when compared to SED+SAL (p>0.05). CONCLUSIONS: Short-term voluntary running activity performed either 1, 3, or 5 days prior to DOX treatment protects against DOX-induced cardiac dysfunction." @default.
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- W2031964146 date "2008-05-01" @default.
- W2031964146 modified "2023-10-16" @default.
- W2031964146 title "Effects of Short-Term Exercise on Doxorubicin-Induced Cardiotoxicity" @default.
- W2031964146 doi "https://doi.org/10.1249/01.mss.0000321862.19090.8d" @default.
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