FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031964166> ?p ?o ?g. }

• W2031964166 endingPage "287" @default.
• W2031964166 startingPage "279" @default.
• W2031964166 abstract "During the development of a Langendorff preparation of isolated mouse hearts, hitherto undescribed cyclic fluctuations in left ventricular pressure and coronary flow were independently observed in three laboratories. Isolated mouse hearts were perfused with crystalloid glucose-containing Krebs-Hensleit buffer in a constant pressure model, and left ventricular pressures were measured via an intraventricular balloon catheter. After acquiring technical skill in preparing the mouse hearts, the perfusionists observed that fluctuations in cardiac performance with a cycle period lasting 5-10 min occurred shortly after initiation of perfusion. Each fluctuation cycle consisted of a phase of increase and a phase of decrease. Synchronized with the fluctuations in left ventricular pressure, increases and decreases in dP/dt max took place. Analogous fluctuations in coronary flow occurred, with onset 1-2 min later than changes in left ventricular systolic pressure. In some preparations a gradual ST-segment elevation was seen on the electrocardiogram during the systolic pressure increase phase. The amplitude of the fluctuations could be augmented by increasing the perfusion pressure, and reduced, but not abolished, by lowering the pressure. Changes in buffer calcium, magnesium, or sodium concentration did not alter the fluctuations, nor did any change of anaesthetics, mouse strain, or left ventricular drainage. Altering the perfusion mode from constant pressure to constant flow did not prevent the occurrence of the cyclic fluctuations. The hearts became stable and the fluctuations disappeared when the buffer was supplemented with 2 mm pyruvate. In the present study, pyruvate given throughout stabilization and reperfusion also markedly attenuated the ischaemic insult, as evidenced by the delayed ischaemic contracture and a reduced magnitude of ischaemic contracture. A cardioprotective effect was only visible at early reperfusion, did not affect the final functional recovery. In conclusion, a phenomenon of cyclic fluctuations in left ventricular pressure followed by fluctuations in coronary flow was observed in isolated mouse hearts. These could be abolished by adding 2 mm pyruvate to the perfusion buffer. Pyruvate in the buffer also markedly attenuated the post-ischaemic deterioration of cardiac performance seen in this mouse model." @default.
• W2031964166 created "2016-06-24" @default.
• W2031964166 creator A5011548115 @default.
• W2031964166 creator A5035158843 @default.
• W2031964166 creator A5036191289 @default.
• W2031964166 creator A5056330865 @default.
• W2031964166 creator A5085379971 @default.
• W2031964166 date "2002-08-01" @default.
• W2031964166 modified "2023-10-18" @default.
• W2031964166 title "Cyclic fluctuations in the cardiac performance of the isolated Langendorff-perfused mouse heart: pyruvate abolishes the fluctuations and has an anti-ischaemic effect" @default.
• W2031964166 cites W1693234450 @default.
• W2031964166 cites W1963712210 @default.
• W2031964166 cites W1973557736 @default.
• W2031964166 cites W1986289438 @default.
• W2031964166 cites W2024010774 @default.
• W2031964166 cites W2027782932 @default.
• W2031964166 cites W2041620814 @default.
• W2031964166 cites W2066756265 @default.
• W2031964166 cites W2087429709 @default.
• W2031964166 cites W2128788007 @default.
• W2031964166 cites W2469792820 @default.
• W2031964166 doi "https://doi.org/10.1046/j.1365-201x.2002.01003.x" @default.
• W2031964166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12167167" @default.
• W2031964166 hasPublicationYear "2002" @default.
• W2031964166 type Work @default.
• W2031964166 sameAs 2031964166 @default.
• W2031964166 citedByCount "15" @default.
• W2031964166 countsByYear W20319641662014 @default.
• W2031964166 countsByYear W20319641662015 @default.
• W2031964166 countsByYear W20319641662020 @default.
• W2031964166 crossrefType "journal-article" @default.
• W2031964166 hasAuthorship W2031964166A5011548115 @default.
• W2031964166 hasAuthorship W2031964166A5035158843 @default.
• W2031964166 hasAuthorship W2031964166A5036191289 @default.
• W2031964166 hasAuthorship W2031964166A5056330865 @default.
• W2031964166 hasAuthorship W2031964166A5085379971 @default.
• W2031964166 hasConcept C126322002 @default.
• W2031964166 hasConcept C134018914 @default.
• W2031964166 hasConcept C146957229 @default.
• W2031964166 hasConcept C164705383 @default.
• W2031964166 hasConcept C185592680 @default.
• W2031964166 hasConcept C26635844 @default.
• W2031964166 hasConcept C2777055891 @default.
• W2031964166 hasConcept C2777862461 @default.
• W2031964166 hasConcept C2778165595 @default.
• W2031964166 hasConcept C42219234 @default.
• W2031964166 hasConcept C71924100 @default.
• W2031964166 hasConcept C84393581 @default.
• W2031964166 hasConcept C99398487 @default.
• W2031964166 hasConceptScore W2031964166C126322002 @default.
• W2031964166 hasConceptScore W2031964166C134018914 @default.
• W2031964166 hasConceptScore W2031964166C146957229 @default.
• W2031964166 hasConceptScore W2031964166C164705383 @default.
• W2031964166 hasConceptScore W2031964166C185592680 @default.
• W2031964166 hasConceptScore W2031964166C26635844 @default.
• W2031964166 hasConceptScore W2031964166C2777055891 @default.
• W2031964166 hasConceptScore W2031964166C2777862461 @default.
• W2031964166 hasConceptScore W2031964166C2778165595 @default.
• W2031964166 hasConceptScore W2031964166C42219234 @default.
• W2031964166 hasConceptScore W2031964166C71924100 @default.
• W2031964166 hasConceptScore W2031964166C84393581 @default.
• W2031964166 hasConceptScore W2031964166C99398487 @default.
• W2031964166 hasIssue "4" @default.
• W2031964166 hasLocation W20319641661 @default.
• W2031964166 hasLocation W20319641662 @default.
• W2031964166 hasOpenAccess W2031964166 @default.
• W2031964166 hasPrimaryLocation W20319641661 @default.
• W2031964166 hasRelatedWork W1985145910 @default.
• W2031964166 hasRelatedWork W1990014982 @default.
• W2031964166 hasRelatedWork W2075052799 @default.
• W2031964166 hasRelatedWork W2095266698 @default.
• W2031964166 hasRelatedWork W2101762585 @default.
• W2031964166 hasRelatedWork W2117806488 @default.
• W2031964166 hasRelatedWork W2154189205 @default.
• W2031964166 hasRelatedWork W2394582558 @default.
• W2031964166 hasRelatedWork W2410782158 @default.
• W2031964166 hasRelatedWork W2411021107 @default.
• W2031964166 hasVolume "175" @default.
• W2031964166 isParatext "false" @default.
• W2031964166 isRetracted "false" @default.
• W2031964166 magId "2031964166" @default.
• W2031964166 workType "article" @default.