FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031971253> ?p ?o ?g. }

• W2031971253 endingPage "131" @default.
• W2031971253 startingPage "120" @default.
• W2031971253 abstract "Smith-Lemli-Opitz (SLO) syndrome is a congenital disorder characterized by severe mental retardation. Patients with SLO lack 7-dehydrocholesterol (7 dH) reductase, which catalyzes the last step of cholesterol synthesis. Administration of an agent that blocks 7 dH cholesterol reductase, BM 15.966 (BM), leads to a biochemical profile which resembles that of SLO patients, i.e., lower plasma, live and brain cholesterol levels accompanied by the appearance of the precursors 7 dH and 8 dH cholesterol. In this article we address the functional consequences of chronic BM treatment on new motor learning by assessing acquisition of the classically conditioned eyeblink response. Just-weaned rats were fed BM by gavage for four months, with half of these rats given exogenous cholesterol during the last two months of BM treatment. Acquisition of the eyeblink response was impaired in BM-treated rats. Impaired acquisition of the eyeblink response was not accompanied by alterations in responsiveness to either the conditioned or unconditioned stimulus. Exogenous cholesterol, a clinically relevant countertreatment, failed to correct for the learning impairment produced by BM treatment. Chronic treatment with a cholesterol synthesis-blocking agent impaired associative learning in just-weaned rats." @default.
• W2031971253 created "2016-06-24" @default.
• W2031971253 creator A5031458824 @default.
• W2031971253 creator A5055947582 @default.
• W2031971253 creator A5059906513 @default.
• W2031971253 creator A5076629172 @default.
• W2031971253 creator A5089441541 @default.
• W2031971253 date "2000-04-01" @default.
• W2031971253 modified "2023-09-25" @default.
• W2031971253 title "Blocking cholesterol synthesis impairs acquisition of the classically conditioned eyeblink response" @default.
• W2031971253 cites W1902852842 @default.
• W2031971253 cites W1964390696 @default.
• W2031971253 cites W1969626208 @default.
• W2031971253 cites W1971691605 @default.
• W2031971253 cites W1979622298 @default.
• W2031971253 cites W1980698842 @default.
• W2031971253 cites W1989008618 @default.
• W2031971253 cites W2010863506 @default.
• W2031971253 cites W2017999359 @default.
• W2031971253 cites W2033187770 @default.
• W2031971253 cites W2042047528 @default.
• W2031971253 cites W2053521638 @default.
• W2031971253 cites W2069657583 @default.
• W2031971253 cites W2072446098 @default.
• W2031971253 cites W2073117647 @default.
• W2031971253 cites W2082241244 @default.
• W2031971253 cites W2089090377 @default.
• W2031971253 cites W2145008878 @default.
• W2031971253 cites W2145484925 @default.
• W2031971253 cites W2151611922 @default.
• W2031971253 cites W2156679744 @default.
• W2031971253 cites W2163592726 @default.
• W2031971253 cites W2346232969 @default.
• W2031971253 cites W2394995650 @default.
• W2031971253 cites W2403486994 @default.
• W2031971253 cites W24048935 @default.
• W2031971253 cites W4232102521 @default.
• W2031971253 cites W4246524406 @default.
• W2031971253 cites W4290127745 @default.
• W2031971253 doi "https://doi.org/10.1007/bf02688771" @default.
• W2031971253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11021337" @default.
• W2031971253 hasPublicationYear "2000" @default.
• W2031971253 type Work @default.
• W2031971253 sameAs 2031971253 @default.
• W2031971253 citedByCount "7" @default.
• W2031971253 countsByYear W20319712532013 @default.
• W2031971253 crossrefType "journal-article" @default.
• W2031971253 hasAuthorship W2031971253A5031458824 @default.
• W2031971253 hasAuthorship W2031971253A5055947582 @default.
• W2031971253 hasAuthorship W2031971253A5059906513 @default.
• W2031971253 hasAuthorship W2031971253A5076629172 @default.
• W2031971253 hasAuthorship W2031971253A5089441541 @default.
• W2031971253 hasConcept C104788683 @default.
• W2031971253 hasConcept C105795698 @default.
• W2031971253 hasConcept C126322002 @default.
• W2031971253 hasConcept C134018914 @default.
• W2031971253 hasConcept C134651460 @default.
• W2031971253 hasConcept C15744967 @default.
• W2031971253 hasConcept C169760540 @default.
• W2031971253 hasConcept C181199279 @default.
• W2031971253 hasConcept C185592680 @default.
• W2031971253 hasConcept C2778163477 @default.
• W2031971253 hasConcept C2780716534 @default.
• W2031971253 hasConcept C2781081984 @default.
• W2031971253 hasConcept C2983526489 @default.
• W2031971253 hasConcept C3017755632 @default.
• W2031971253 hasConcept C33923547 @default.
• W2031971253 hasConcept C39617858 @default.
• W2031971253 hasConcept C45262634 @default.
• W2031971253 hasConcept C55493867 @default.
• W2031971253 hasConcept C71924100 @default.
• W2031971253 hasConceptScore W2031971253C104788683 @default.
• W2031971253 hasConceptScore W2031971253C105795698 @default.
• W2031971253 hasConceptScore W2031971253C126322002 @default.
• W2031971253 hasConceptScore W2031971253C134018914 @default.
• W2031971253 hasConceptScore W2031971253C134651460 @default.
• W2031971253 hasConceptScore W2031971253C15744967 @default.
• W2031971253 hasConceptScore W2031971253C169760540 @default.
• W2031971253 hasConceptScore W2031971253C181199279 @default.
• W2031971253 hasConceptScore W2031971253C185592680 @default.
• W2031971253 hasConceptScore W2031971253C2778163477 @default.
• W2031971253 hasConceptScore W2031971253C2780716534 @default.
• W2031971253 hasConceptScore W2031971253C2781081984 @default.
• W2031971253 hasConceptScore W2031971253C2983526489 @default.
• W2031971253 hasConceptScore W2031971253C3017755632 @default.
• W2031971253 hasConceptScore W2031971253C33923547 @default.
• W2031971253 hasConceptScore W2031971253C39617858 @default.
• W2031971253 hasConceptScore W2031971253C45262634 @default.
• W2031971253 hasConceptScore W2031971253C55493867 @default.
• W2031971253 hasConceptScore W2031971253C71924100 @default.
• W2031971253 hasIssue "2" @default.
• W2031971253 hasLocation W20319712531 @default.
• W2031971253 hasLocation W20319712532 @default.
• W2031971253 hasOpenAccess W2031971253 @default.
• W2031971253 hasPrimaryLocation W20319712531 @default.
• W2031971253 hasRelatedWork W168109911 @default.
• W2031971253 hasRelatedWork W1980284406 @default.
• W2031971253 hasRelatedWork W2017310397 @default.

• next