Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031985863> ?p ?o ?g. }
- W2031985863 endingPage "49" @default.
- W2031985863 startingPage "41" @default.
- W2031985863 abstract "The primary amphipathic peptide Ac-Met-Gly-Leu-Gly-Leu-Trp-Leu-Leu-Val-Leu10-Ala-Ala-Ala-Leu-Gln-Gly-Ala-Lys-Lys-Lys20-Arg-Lys-Val-NH-CH2-CH2-SH called SPM was able to induce formation of ion channels into planar lipid bilayers with main conductance values of 75 and 950 pS in 1 M KCl. The 75 pS value can be attributed to an aggregate composed of five monomers since the corresponding five-unit bundle (5-SPM) also presented a 70 pS channels under the same conditions. The upper 950 pS level would be generated by a hexameric aggregate. Ion channels induced by both SPM and its pentameric bundle are slightly cation selective but not voltage-dependent. The structural studies showed that the SPM and 5-SPM possess mainly an alpha-helical structure (approximately 40%) and are strongly embedded in the bilayer. This behaviour and the strong hydrophobic interactions occurring between helices in the bundle induce a strong stabilization of 5-SPM in the bilayer and would be responsible for the stepwise current fluctuations observed during the incorporation of 5-SPM into the membrane." @default.
- W2031985863 created "2016-06-24" @default.
- W2031985863 creator A5029378838 @default.
- W2031985863 creator A5034626458 @default.
- W2031985863 creator A5036457274 @default.
- W2031985863 creator A5051380897 @default.
- W2031985863 creator A5056232875 @default.
- W2031985863 creator A5062545741 @default.
- W2031985863 date "2001-01-01" @default.
- W2031985863 modified "2023-10-03" @default.
- W2031985863 title "Conformation and ion channel properties of a five-helix bundle protein" @default.
- W2031985863 cites W1967242463 @default.
- W2031985863 cites W1974178315 @default.
- W2031985863 cites W1976379170 @default.
- W2031985863 cites W1977811062 @default.
- W2031985863 cites W1984167849 @default.
- W2031985863 cites W1988901585 @default.
- W2031985863 cites W1995763748 @default.
- W2031985863 cites W2004364628 @default.
- W2031985863 cites W2007446604 @default.
- W2031985863 cites W2009571951 @default.
- W2031985863 cites W2011283083 @default.
- W2031985863 cites W2014023237 @default.
- W2031985863 cites W2014550271 @default.
- W2031985863 cites W2023609943 @default.
- W2031985863 cites W2024043943 @default.
- W2031985863 cites W2038720675 @default.
- W2031985863 cites W2039457108 @default.
- W2031985863 cites W2041541769 @default.
- W2031985863 cites W2042098678 @default.
- W2031985863 cites W2042143995 @default.
- W2031985863 cites W2042197077 @default.
- W2031985863 cites W2049708286 @default.
- W2031985863 cites W2054599268 @default.
- W2031985863 cites W2059919577 @default.
- W2031985863 cites W2061556264 @default.
- W2031985863 cites W2064093490 @default.
- W2031985863 cites W2065866429 @default.
- W2031985863 cites W2079116535 @default.
- W2031985863 cites W2083780488 @default.
- W2031985863 cites W2084190681 @default.
- W2031985863 cites W2084488068 @default.
- W2031985863 cites W2086299962 @default.
- W2031985863 cites W2089659785 @default.
- W2031985863 cites W2108224709 @default.
- W2031985863 cites W2126606962 @default.
- W2031985863 cites W2949250147 @default.
- W2031985863 cites W2949657311 @default.
- W2031985863 cites W4299496276 @default.
- W2031985863 doi "https://doi.org/10.1002/psc.293" @default.
- W2031985863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11245204" @default.
- W2031985863 hasPublicationYear "2001" @default.
- W2031985863 type Work @default.
- W2031985863 sameAs 2031985863 @default.
- W2031985863 citedByCount "8" @default.
- W2031985863 countsByYear W20319858632013 @default.
- W2031985863 crossrefType "journal-article" @default.
- W2031985863 hasAuthorship W2031985863A5029378838 @default.
- W2031985863 hasAuthorship W2031985863A5034626458 @default.
- W2031985863 hasAuthorship W2031985863A5036457274 @default.
- W2031985863 hasAuthorship W2031985863A5051380897 @default.
- W2031985863 hasAuthorship W2031985863A5056232875 @default.
- W2031985863 hasAuthorship W2031985863A5062545741 @default.
- W2031985863 hasConcept C114614502 @default.
- W2031985863 hasConcept C121932024 @default.
- W2031985863 hasConcept C12554922 @default.
- W2031985863 hasConcept C145148216 @default.
- W2031985863 hasConcept C15920480 @default.
- W2031985863 hasConcept C159985019 @default.
- W2031985863 hasConcept C166940927 @default.
- W2031985863 hasConcept C170493617 @default.
- W2031985863 hasConcept C178790620 @default.
- W2031985863 hasConcept C185592680 @default.
- W2031985863 hasConcept C18903297 @default.
- W2031985863 hasConcept C192157962 @default.
- W2031985863 hasConcept C192562407 @default.
- W2031985863 hasConcept C203087120 @default.
- W2031985863 hasConcept C2778134712 @default.
- W2031985863 hasConcept C2778530040 @default.
- W2031985863 hasConcept C2779281246 @default.
- W2031985863 hasConcept C2779965526 @default.
- W2031985863 hasConcept C33923547 @default.
- W2031985863 hasConcept C39944091 @default.
- W2031985863 hasConcept C41625074 @default.
- W2031985863 hasConcept C47701112 @default.
- W2031985863 hasConcept C50254741 @default.
- W2031985863 hasConcept C521977710 @default.
- W2031985863 hasConcept C55493867 @default.
- W2031985863 hasConcept C67407626 @default.
- W2031985863 hasConcept C8010536 @default.
- W2031985863 hasConcept C86803240 @default.
- W2031985863 hasConceptScore W2031985863C114614502 @default.
- W2031985863 hasConceptScore W2031985863C121932024 @default.
- W2031985863 hasConceptScore W2031985863C12554922 @default.
- W2031985863 hasConceptScore W2031985863C145148216 @default.
- W2031985863 hasConceptScore W2031985863C15920480 @default.
- W2031985863 hasConceptScore W2031985863C159985019 @default.
- W2031985863 hasConceptScore W2031985863C166940927 @default.