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- W2031986312 abstract "Contrasting effects of okadaic acid (OKA) on neutrophil (PMN) superoxide anion (O2−) generation have been reported. In this study, we examined the effect of OKA on phorbol myristate acetate (PMA)-stimulated O2− generation in rat PMNs primed with LPS in vivo (LPS-PMN) and saline-treated rat PMNs (SAL-PMN). The following results were observed: (1) OKA, but neither genistein nor vanadate, markedly reduced O2− generation in a dose and time-dependent manner; (2) genistein, a tyrosine kinase inhibitor, as well as OKA, reduced tyrosine phosphorylation; (3) sodium orthovanadate, a tyrosine phosphatase inhibitor, potently enhanced tyrosine phosphorylation. Our studies suggest that OKA might reduce tyrosine phosphorylation by affecting the activity of tyrosine phosphatases regulated by serine-threonine phosphorylation. © 1997 Elsevier Science Inc." @default.
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- W2031986312 date "1997-01-01" @default.
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- W2031986312 title "THE MARINE TOXIN OKADAIC ACID REDUCES O 2 − GENERATION AND TYROSINE PHOSPHORYLATION IN LPS-PRIMED RAT NEUTROPHILS" @default.
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- W2031986312 doi "https://doi.org/10.1016/s0024-3205(97)00713-3" @default.
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