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- W2031991512 abstract "Neural fate specification in Drosophila is promoted by the products of the proneural genes, such as those of the achaete-scute complex, and antagonized by the products of the Enhancer of split [E(spl)] complex, hairy, and extramacrochaetae. As all these proteins bear a helix-loop-helix (HLH) dimerization domain, we investigated their potential pairwise interactions using the yeast two-hybrid system. The fidelity of the system was established by its ability to closely reproduce the already documented interactions among Da, Ac, Sc, and Extramacrochaetae. We show that the seven E(spl) basic HLH proteins can form homo- and heterodimers inter-se with distinct preferences. We further show that a subset of E(spl) proteins can heterodimerize with Da, another subset can heterodimerize with proneural proteins, and yet another with both, indicating specialization within the E(spl) family. Hairy displays no interactions with any of the HLH proteins tested. It does interact with the non-HLH protein Groucho, which itself interacts with all E(spl) basic HLH proteins, but with none of the proneural proteins or Da. We investigated the structural requirements for some of these interactions by site-specific and deletion mutagenesis." @default.
- W2031991512 created "2016-06-24" @default.
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- W2031991512 creator A5010193690 @default.
- W2031991512 creator A5061232482 @default.
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- W2031991512 date "1997-11-25" @default.
- W2031991512 modified "2023-10-01" @default.
- W2031991512 title "A network of interacting transcriptional regulators involved in <i>Drosophila</i> neural fate specification revealed by the yeast two-hybrid system" @default.
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- W2031991512 doi "https://doi.org/10.1073/pnas.94.24.13099" @default.
- W2031991512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/24269" @default.
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- W2031991512 hasPublicationYear "1997" @default.
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