Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032004306> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2032004306 endingPage "1438" @default.
- W2032004306 startingPage "1433" @default.
- W2032004306 abstract "Background Equine recurrent airway obstruction ( RAO ) is characterized by airway inflammation, bronchoconstriction, and increased mucus production in the airways. Anticholinergic drugs like atropine induce bronchodilatation and rapid improvement in lung function. N‐butylscopolammonium bromide ( NBB ) is an anticholinergic drug used to relieve spasmodic colic in horses, but its effect on airway smooth muscle is unknown. Objective To evaluate the effect of NBB on clinical signs and lung function of RAO ‐affected horses. Animals Nine horses diagnosed with RAO . Methods Double‐blind, placebo‐controlled, randomized crossover trial. Horses were challenged with moldy hay until a maximum change in transpulmonary pressure (∆ P L max ) > 15 cmH 2 O was achieved. NBB (0.3 mg/kg) or placebo (0.9% saline) was administered IV. Clinical scores and lung function were recorded at baseline and then periodically after treatment administration. Horses were allowed a 6‐week washout before administration of opposite treatments. Results Clinical score at 10 and 30 minutes (8.7 ± 2.8 and 8.7 ± 3.2, respectively) after NBB administration was significantly lower than baseline (10.8 ± 2.4). NBB administration resulted in a significant decrease in ∆ P L max (baseline: 35.1 ± 6.9 cmH 2 O) starting 2 minutes after administration (16.3 ± 6.6 cmH 2 O) with a maximum decline observed at 10 minutes (13.5 ± 7.1 cmH 2 O). ∆ P L max values between 60 and 120 minutes after NBB administration were not different from placebo. Conclusion and Clinical Importance N‐butylscopolammonium bromide is a potent bronchodilator, reaching maximum effect 10 minutes after intravenous administration. This effect dissipates within 1 hour of drug administration." @default.
- W2032004306 created "2016-06-24" @default.
- W2032004306 creator A5000040625 @default.
- W2032004306 creator A5009031784 @default.
- W2032004306 creator A5032057582 @default.
- W2032004306 creator A5041884597 @default.
- W2032004306 creator A5069671656 @default.
- W2032004306 creator A5078360870 @default.
- W2032004306 date "2012-08-27" @default.
- W2032004306 modified "2023-10-16" @default.
- W2032004306 title "Effects of N-Butylscopolammonium Bromide on Lung Function in Horses with Recurrent Airway Obstruction" @default.
- W2032004306 cites W1546751164 @default.
- W2032004306 cites W1930695014 @default.
- W2032004306 cites W1964546636 @default.
- W2032004306 cites W2021456388 @default.
- W2032004306 cites W2031702137 @default.
- W2032004306 cites W2042524053 @default.
- W2032004306 cites W2043491766 @default.
- W2032004306 cites W2071146177 @default.
- W2032004306 cites W2112761854 @default.
- W2032004306 cites W2114978977 @default.
- W2032004306 cites W2146063719 @default.
- W2032004306 cites W2153502543 @default.
- W2032004306 cites W2169987067 @default.
- W2032004306 cites W2174807697 @default.
- W2032004306 cites W2182336116 @default.
- W2032004306 cites W2396667495 @default.
- W2032004306 doi "https://doi.org/10.1111/j.1939-1676.2012.00992.x" @default.
- W2032004306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22925156" @default.
- W2032004306 hasPublicationYear "2012" @default.
- W2032004306 type Work @default.
- W2032004306 sameAs 2032004306 @default.
- W2032004306 citedByCount "22" @default.
- W2032004306 countsByYear W20320043062014 @default.
- W2032004306 countsByYear W20320043062015 @default.
- W2032004306 countsByYear W20320043062017 @default.
- W2032004306 countsByYear W20320043062018 @default.
- W2032004306 countsByYear W20320043062019 @default.
- W2032004306 countsByYear W20320043062020 @default.
- W2032004306 countsByYear W20320043062022 @default.
- W2032004306 crossrefType "journal-article" @default.
- W2032004306 hasAuthorship W2032004306A5000040625 @default.
- W2032004306 hasAuthorship W2032004306A5009031784 @default.
- W2032004306 hasAuthorship W2032004306A5032057582 @default.
- W2032004306 hasAuthorship W2032004306A5041884597 @default.
- W2032004306 hasAuthorship W2032004306A5069671656 @default.
- W2032004306 hasAuthorship W2032004306A5078360870 @default.
- W2032004306 hasBestOaLocation W20320043061 @default.
- W2032004306 hasConcept C105922876 @default.
- W2032004306 hasConcept C126322002 @default.
- W2032004306 hasConcept C142724271 @default.
- W2032004306 hasConcept C204787440 @default.
- W2032004306 hasConcept C27081682 @default.
- W2032004306 hasConcept C2776042228 @default.
- W2032004306 hasConcept C2776371117 @default.
- W2032004306 hasConcept C2778333281 @default.
- W2032004306 hasConcept C2778689640 @default.
- W2032004306 hasConcept C2780769369 @default.
- W2032004306 hasConcept C2781018748 @default.
- W2032004306 hasConcept C42219234 @default.
- W2032004306 hasConcept C71924100 @default.
- W2032004306 hasConcept C87813604 @default.
- W2032004306 hasConceptScore W2032004306C105922876 @default.
- W2032004306 hasConceptScore W2032004306C126322002 @default.
- W2032004306 hasConceptScore W2032004306C142724271 @default.
- W2032004306 hasConceptScore W2032004306C204787440 @default.
- W2032004306 hasConceptScore W2032004306C27081682 @default.
- W2032004306 hasConceptScore W2032004306C2776042228 @default.
- W2032004306 hasConceptScore W2032004306C2776371117 @default.
- W2032004306 hasConceptScore W2032004306C2778333281 @default.
- W2032004306 hasConceptScore W2032004306C2778689640 @default.
- W2032004306 hasConceptScore W2032004306C2780769369 @default.
- W2032004306 hasConceptScore W2032004306C2781018748 @default.
- W2032004306 hasConceptScore W2032004306C42219234 @default.
- W2032004306 hasConceptScore W2032004306C71924100 @default.
- W2032004306 hasConceptScore W2032004306C87813604 @default.
- W2032004306 hasIssue "6" @default.
- W2032004306 hasLocation W20320043061 @default.
- W2032004306 hasLocation W20320043062 @default.
- W2032004306 hasOpenAccess W2032004306 @default.
- W2032004306 hasPrimaryLocation W20320043061 @default.
- W2032004306 hasRelatedWork W1991320929 @default.
- W2032004306 hasRelatedWork W1992518275 @default.
- W2032004306 hasRelatedWork W1999147516 @default.
- W2032004306 hasRelatedWork W2034688708 @default.
- W2032004306 hasRelatedWork W2052298560 @default.
- W2032004306 hasRelatedWork W2062305906 @default.
- W2032004306 hasRelatedWork W2125746984 @default.
- W2032004306 hasRelatedWork W2400866968 @default.
- W2032004306 hasRelatedWork W2401021177 @default.
- W2032004306 hasRelatedWork W4235595524 @default.
- W2032004306 hasVolume "26" @default.
- W2032004306 isParatext "false" @default.
- W2032004306 isRetracted "false" @default.
- W2032004306 magId "2032004306" @default.
- W2032004306 workType "article" @default.