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- W2032010596 abstract "Abstract The urinary elimination of thiocyanate was investigated in male and female rats following the chronic administration of potassium cyanide. Female rats dosed at the level of 5 mg KCN/kg once a week and twice a week respectively, displayed no significant difference in the excretion of thiocyanate in urine after periods of up to eight weeks of study. Similarly, male rats that were administered 5 mg/KCN/kg twice weekly showed no significant difference in the amount of thiocyanate excreted. The elimination patterns of thiocyanate in male and female rats showed no significant differences. The results suggest that a substrate saturation phenomenon is not operative with cyanide metabolism at the dosage level of potassium cyanide employed in this study. This is contrary to a previously published study which reported that the urinary excretion of thiocyanate decreased after chronic potassium cyanide administration." @default.
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- W2032010596 date "2009-03-13" @default.
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- W2032010596 title "Chronic Administration of Cyanide: Urinary Excretion of Thiocyanate in Male and Female Rats" @default.
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- W2032010596 doi "https://doi.org/10.1111/j.1600-0773.1977.tb02122.x" @default.
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