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- W2032020247 abstract "The relationships between cardiac performance and oxygen usage were explored in 19 newborn lambs (5 hours to 8 days old), and the influence of inotropic stimulation was studied. A preparation was developed to measure coronary sinus flow and myocardial oxygen consumption (MVo 2 ) under controlled hemodynamic conditions. Using a gelatin injection technique, we determined that more than 90% of the measured sinus flow originated from left heart tissue; less than 10% was derived from right ventricular myocardium. Changes in contractility were produced by intravenous infusion of norepinephrine or acetylstrophanthidin. Norepinephrine (1-2.4 µg/min kg -1 ) or acetylstrophanthidin (5 µg/min kg -1 ) produced increases in the maximal rate of rise of left ventricular pressure and large reductions in left ventricular enddiastolic pressure, but the changes in MVo 2 in lambs with constant aortic blood pressure, cardiac output, and heart rate were minimal. Ventricular function curves demonstrated a significant relationship between end-diastolic pressure and MVo 2 (P < 0.01). For a given left ventricular end-diastolic pressure, MVo 2 was approximately 3 ml/min 100 g -1 left ventricle greater during the infusion of norepinephrine. Therefore, net changes in MVo 2 with inotropic stimulation represented a balance between reciprocal changes in diastolic pressure (and volume) and contractility. The enhanced oxygen cost of increased contractility might be masked by a reduction in heart size (reduced wall stress). Ventricular function was reduced below initial control values following the infusion of norepinephrine in 3 lambs. This reduction correlated with a concomitant reduction in MVo 2 and percent extraction but not with a reduction in flow. Lambs that did not show mechanical depression demonstrated no reduction in MVo 2 . These findings suggest a metabolic basis for catechol dependence which might have special importance for the newborn lamb with its incompletely developed catechol enzyme systems." @default.
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- W2032020247 date "1973-04-01" @default.
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- W2032020247 title "Influence of Norepinephrine and Digitalis on Myocardial Oxygen Consumption in the Newborn Lamb" @default.
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- W2032020247 doi "https://doi.org/10.1161/01.res.32.4.471" @default.
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